Development of GSH-Stimuli-Responsive Micelles Using a Targeted Paclitaxel Prodrug for Enhanced Anticancer Effect

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 538 - 538

Опубликована: Апрель 21, 2025

Background: Cancer ranks as a leading cause of death worldwide. It is urgent to develop intelligent co-delivery systems for cancer chemotherapy achieve reduced side-effects and enhanced therapeutic efficacy. Methods: We chose oligo-hyaluronic acid (oHA, low molecular weight HA) the carrier, adriamycin (ADM) paclitaxel (PTX) co-delivered drugs. The oHA-ss-PTX macromolecular prodrug was synthesized by introducing glutathione-stimuli-responsive disulfide bonds through chemical reactions. Then, we constructed ADM-loading micelles (ADM/oHA-ss-PTX) in one step microfluidic preparation. delivery efficacy evaluated comprehensively vitro vivo. biocompatibility ADM/oHA-ss-PTX assessed hemolysis activity analysis, BSA adsorption testing, cell viability assay endothelial cells. Results: resulting possessed dynamic size (127 ± 1.4 nm, zeta potential −9.0 mV), high drug loading content approximately 21.2% 7.6% (ADM). Compared with free ADM+PTX, showed blood stability more efficiently inhibited proliferation. Moreover, due CD44-mediated endocytosis pathway, greater number were absorbed A549 cells than oHA-saturated In vivo experiments also that had excellent effects targeting ability. These results show promising platform sequential therapy CD44-positive cancer. Conclusions: conclusion, these convincingly demonstrate hold great promise novel co-delivering multiple Their properties not only validate this approach cancers but pave way future clinical translation further optimization treatment.

Язык: Английский

Micro-Nano Convergence-Driven Radiotheranostic Revolution in Hepatocellular Carcinoma

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

Radiotherapy, as an important means of treating hepatocellular carcinoma (HCC), has shown unique therapeutic advantages, especially in patients who are unable to undergo surgery or transplantation. It mainly includes external radiotherapy, transarterial radioembolization and intratumoral radioactive particle implantation. However, under the influence factors such hypoxic characteristics liver tumor microenvironment radioresistance cells, effect radiotherapy may be unstable cause side effects, affecting quality life patients. In recent years, with development nanotechnology, drug delivery systems based on micro-nanomaterials have provided new solutions for improving HCC. Despite this, application micro-nano treatment HCC still faces some challenges, including vivo safety metabolism materials. This article reviews latest progress materials HCC, their radiosensitization clinical translation potential. systematically analyzes role internal sensitization radioimmunotherapy explores advantages

Язык: Английский

Micro-nanomaterials-engineered delivery systems for reshaping the tumor immune microenvironment in hepatocellular carcinoma

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111390 - 111390

Опубликована: Май 1, 2025

Язык: Английский