Black carbon emissions persistence: Evidence from 27 European Union countries using fractional integration
Renewable and Sustainable Energy Reviews,
Год журнала:
2025,
Номер
212, С. 115327 - 115327
Опубликована: Янв. 25, 2025
Язык: Английский
Solubility of gemcitabine (an anticancer drug) in supercritical carbon dioxide green solvent: Experimental measurement and thermodynamic modeling
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 6, 2025
In
order
to
develop
supercritical
fluid
(SCF)
processes
for
the
micro
or
nanosizing
of
solid
solute
components,
such
as
pharmaceuticals,
it
is
essential
assess
their
solubility
in
solvents
including
carbon
dioxide
(SC–CO2).
This
crucial
step
fundamental
choosing
and
evaluating
SCF
technology.
A
statistical
method
was
developed
used
determine
gemcitabine
SC-CO2.
The
measurements
at
various
pressures
temperatures
were
conducted
using
UV–vis
analysis.
Two
model
types
correlate
data:
semi-empirical
(with
3–6
parameters)
equation
state
(EoS)
models.
SC-CO2
a
static
308–338
K
120–270
bar
measured
modeled
first
time.
Solubility
ranged
from
0.1274
×
10−
5
1.8128
mole
fraction
0.00295
0.08489
kg/L.
PR
EoS
performed
best
308
with
an
AARD
12.58%,
SRK
excelled
318–338
AARDs
between
12.93
15.68%.
Application
Joback
(AARD
12.04–27.13%)
COSMO-RS
18.68–31.28%)
models
also
compared.
Bian
et
al.
showed
fit
among
density-based
16.62%.
Язык: Английский
Determination of 5-fluorouracil anticancer drug solubility in supercritical CO2using semi-empirical and machine learning models
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 7, 2025
In
order
to
provide
the
facilities
design
supercritical
fluid
(SCF)
processes
for
micro
or
nanosizing
of
solid
solute
compounds
such
as
drugs,
it
is
essential
obtain
their
solubility
in
green
solvents
like
pressurized
CO2.
This
important
role
first
stage
assessing
each
SCF
technology.
A
statistical
method
was
developed
time
and
employed
determine
5-fluorouracil
(5-Fu)
solubility.
The
measurements
were
performed
at
different
pressures
(120-270
bar)
temperatures
(308-338
K)
through
UV-vis
spectrophotometry,
time.
obtained
between
0.0024
0.0176
g/L.
5-Fu
mole
fraction
constant
temperature,
increases
with
an
increase
pressure.
Whereas,
a
crossover
point
has
been
seen.
Three
models
approaches
applied
correlate
model
experimental
data
set:
(i)
seven
density-based
models,
(ii)
PR
equations
state
(vdW2
mixing
rule),
(iii)
machine
learning-based
namely
non-linear
regressions,
Random
Forest,
Gradient
Boosting,
Decision
Tree,
Kernel
Ridge.
All
tested
successfully
within
acceptable
accuracy.
Meanwhile,
empirical
suggested
by
Sodeifian
2,
superior
lowest
AARD%
(AARD
=
4.12%).
Finally,
total,
solvation,
vaporization
enthalpies
drug/Sc-CO2
binary
system
determined
using
semi-empirical
correlations,
Язык: Английский
Application of theoretical and semi-empirical equations for modeling of Maprotiline hydrochloride (anti-depressant) drug solubility in SC-CO2
Measurement,
Год журнала:
2025,
Номер
unknown, С. 117508 - 117508
Опубликована: Апрель 1, 2025
Язык: Английский
Universal data-driven models to estimate the solubility of anti-cancer drugs in supercritical carbon dioxide: Correlation development and machine learning modeling
Journal of CO2 Utilization,
Год журнала:
2025,
Номер
92, С. 103021 - 103021
Опубликована: Янв. 13, 2025
Язык: Английский