Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 621 - 658
Опубликована: Янв. 1, 2025
Язык: Английский
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Июль 7, 2023
Abstract Over the past several decades, mRNA vaccines have evolved from a theoretical concept to clinical reality. These offer advantages over traditional vaccine techniques, including their high potency, rapid development, low-cost manufacturing, and safe administration. However, until recently, concerns instability inefficient distribution of in vivo limited utility. Fortunately, recent technological advancements mostly resolved these concerns, resulting development numerous vaccination platforms for infectious diseases various types cancer. shown promising outcomes both animal models humans. This study highlights potential as alternative approach conventional techniques cancer treatment. review article aims provide thorough detailed examination vaccines, mechanisms action applications immunotherapy. Additionally, will analyze current state technology highlight future directions implementation this platform mainstream therapeutic option. The also discuss challenges limitations such stability distribution, suggest ways overcome issues. By providing comprehensive overview critical analysis contribute advancement innovative
Язык: Английский
Процитировано
90
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Окт. 3, 2023
Lipid-based polymeric nanoparticles are the highly popular carrier systems for cancer drug therapy. But presently, detailed investigations have revealed their flaws as delivery carriers. Lipid polymer hybrid (LPHNPs) advanced core-shell nanoconstructs with a core region enclosed by lipidic layer, presumed to be derived from both liposomes and nanounits. This unique concept is of utmost importance combinable platform in oncology due its dual structured character. To add advantage restrict one's limitation other, LPHNPs been designed so gain number advantages such stability, high loading cargo, increased biocompatibility, rate-limiting controlled release, elevated half-lives well therapeutic effectiveness while minimizing drawbacks. The outer shell, particular, can functionalized variety ways stimuli-responsive moieties ligands provide intelligent holding active targeting antineoplastic medicines, transport genes, theragnostic. review comprehensively provides insight into recent substantial advancements developing strategies treating various using LPHNPs. bioactivity assessment factors also highlighted discussion future clinical prospects.
Язык: Английский
Процитировано
87
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141394 - 141394
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
3
Hybrid Advances, Год журнала: 2024, Номер 6, С. 100210 - 100210
Опубликована: Май 1, 2024
Traditional drug delivery techniques often have drawbacks such inadequate bioavailability, quick clearance, and non-specific targeting, which may result in unfavorable side effects. Hybrid nanocarriers composed of nanoclay the potential to be a viable solution these problems. The goal this work was design biocompatible hybrid nanocarrier that would release curcumin under regulated conditions specific locations, especially cancer cells. FTIR, XRD, FESEM were used effectively construct evaluate our polyvinyl pyrrolidone/polyethylene glycol/montmorillonite (PVP/PEG/MMT) hydrogels, verifying their synthesis intended features. Zeta DLS studies showed suitable size distribution (∼300 nm) high stability. encapsulation efficiency profile assessed using use UV spectrophotometry dialysis bag technique. findings gradual continuous highly impacted by acidic environment (which mimicked characteristics cells), suggesting pH-responsive activity. MTT test vitro cytotoxicity experiments show curcumin-loaded more effective against MCF-7 cells than solution. Increased rates necrosis apoptosis treated with formulation further validated flowcytometry. According results, PVP/PEG/MMT hydrogels lot as cutting-edge strategy for curcumin. They able overcome some traditional improve effectiveness treatment
Язык: Английский
Процитировано
16
Discover Oncology, Год журнала: 2025, Номер 16(1)
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
1
Materials Chemistry and Physics, Год журнала: 2022, Номер 295, С. 127159 - 127159
Опубликована: Дек. 5, 2022
Язык: Английский
Процитировано
38
Computational and Theoretical Chemistry, Год журнала: 2022, Номер 1220, С. 113990 - 113990
Опубликована: Дек. 14, 2022
Язык: Английский
Процитировано
30
Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11
Опубликована: Апрель 4, 2023
Ovarian cancer stands as the fifth most prevalent among women, causing more mortalities than any other disease of female reproductive system. There are numerous histological subtypes ovarian cancer, each which has distinct clinical characteristics, risk factors, cell origins, molecular compositions, and therapeutic options. Typically, it is identified at a late stage, there no efficient screening method. Standard therapies for newly diagnosed cytoreductive surgery platinum-based chemotherapy. The difficulties traditional procedures encourage researchers to search approaches, such nanotechnology. Due unique characteristics matter nanoscale, nanomedicine emerged potent tool creating novel drug carriers that effective have fewer adverse effects treatments. Nanocarriers including liposomes, dendrimers, polymer nanoparticles, micelles properties in surface chemistry, morphology, mechanism action can distinguish between malignant normal cells, paving way targeted delivery. In contrast their non-functionalized counterparts, development functionalized nano-formulations with specific ligands permits selective targeting cancers ultimately increases potential. This review focuses on application various nanomaterials treatment diagnosis advantages over conventional methods, role controlled delivery systems therapy cancer.
Язык: Английский
Процитировано
21
Surfaces and Interfaces, Год журнала: 2022, Номер 29, С. 101739 - 101739
Опубликована: Янв. 23, 2022
Язык: Английский
Процитировано
26
Drug Delivery, Год журнала: 2022, Номер 29(1), С. 3218 - 3232
Опубликована: Окт. 19, 2022
Formulations from nanotechnology platform promote therapeutic drug delivery and offer various advantages such as biocompatibility, non-inflammatory effects, high output, biodegradability, non-toxicity, biocompatibility in comparison with free delivery. Due to inherent shortcomings of conventional cancerous tissues, alternative nanotechnological-based approaches have been developed for ailments. Ovarian cancer is the leading gynecological higher mortality rates due its reoccurrence late diagnosis. In recent years, field medical has witnessed significant progress addressing existing problems improving diagnosis therapy diseases including cancer. Nevertheless, literature current reviews on are mainly focused applications other cancers or diseases. this review, we nanoscale systems ovarian targeted diagnosis, different nanocarriers dendrimers, nanoparticles, liposomes, nanocapsules, nanomicelles discussed. non-functionalized counterparts nanoformulations, potential preferential targeting through ligand functionalized nanoformulations' development reviewed. Furthermore, numerous biomarkers prostatic, mucin 1, CA-125, apoptosis repeat baculoviral inhibitor-5, human epididymis protein-4, e-cadherin identified elucidated review assessment Nanomaterial biosensor-based tumor markers their types explained article. association, nanocarrier also underpinned. To ensure control efficient detection, there an urgent need faster less costly tools arena oncology.
Язык: Английский
Процитировано
26