Micromachines,
Год журнала:
2025,
Номер
16(4), С. 419 - 419
Опубликована: Март 31, 2025
The
rapid
evolution
of
micro-
and
nano-architectures
is
revolutionizing
biomedical
engineering,
particularly
in
the
fields
therapeutic
diagnostic
micromechanics.
This
review
explores
recent
innovations
nanostructured
materials
their
transformative
impact
on
healthcare
applications,
ranging
from
drug
delivery
tissue
engineering
to
biosensing
diagnostics.
Key
advances
fabrication
techniques,
such
as
lithography,
3D
printing,
self-assembly,
have
enabled
unprecedented
control
over
material
properties
functionalities
at
microscopic
scales.
These
engineered
architectures
offer
enhanced
precision
targeting
controlled
release
delivery,
foster
cellular
interactions
improve
sensitivity
specificity
devices.
We
examine
critical
design
parameters,
including
biocompatibility,
mechanical
resilience,
scalability,
which
influence
clinical
efficacy
long-term
stability.
also
highlights
translational
potential
current
limitations
bringing
these
laboratory
research
practical
applications.
By
providing
a
comprehensive
overview
trends,
challenges,
future
perspectives,
this
article
aims
inform
inspire
further
development
that
hold
promise
for
advancing
personalized
medicine.
Abstract
Over
the
past
several
decades,
mRNA
vaccines
have
evolved
from
a
theoretical
concept
to
clinical
reality.
These
offer
advantages
over
traditional
vaccine
techniques,
including
their
high
potency,
rapid
development,
low-cost
manufacturing,
and
safe
administration.
However,
until
recently,
concerns
instability
inefficient
distribution
of
in
vivo
limited
utility.
Fortunately,
recent
technological
advancements
mostly
resolved
these
concerns,
resulting
development
numerous
vaccination
platforms
for
infectious
diseases
various
types
cancer.
shown
promising
outcomes
both
animal
models
humans.
This
study
highlights
potential
as
alternative
approach
conventional
techniques
cancer
treatment.
review
article
aims
provide
thorough
detailed
examination
vaccines,
mechanisms
action
applications
immunotherapy.
Additionally,
will
analyze
current
state
technology
highlight
future
directions
implementation
this
platform
mainstream
therapeutic
option.
The
also
discuss
challenges
limitations
such
stability
distribution,
suggest
ways
overcome
issues.
By
providing
comprehensive
overview
critical
analysis
contribute
advancement
innovative
Lipid-based
polymeric
nanoparticles
are
the
highly
popular
carrier
systems
for
cancer
drug
therapy.
But
presently,
detailed
investigations
have
revealed
their
flaws
as
delivery
carriers.
Lipid
polymer
hybrid
(LPHNPs)
advanced
core-shell
nanoconstructs
with
a
core
region
enclosed
by
lipidic
layer,
presumed
to
be
derived
from
both
liposomes
and
nanounits.
This
unique
concept
is
of
utmost
importance
combinable
platform
in
oncology
due
its
dual
structured
character.
To
add
advantage
restrict
one's
limitation
other,
LPHNPs
been
designed
so
gain
number
advantages
such
stability,
high
loading
cargo,
increased
biocompatibility,
rate-limiting
controlled
release,
elevated
half-lives
well
therapeutic
effectiveness
while
minimizing
drawbacks.
The
outer
shell,
particular,
can
functionalized
variety
ways
stimuli-responsive
moieties
ligands
provide
intelligent
holding
active
targeting
antineoplastic
medicines,
transport
genes,
theragnostic.
review
comprehensively
provides
insight
into
recent
substantial
advancements
developing
strategies
treating
various
using
LPHNPs.
bioactivity
assessment
factors
also
highlighted
discussion
future
clinical
prospects.
Hybrid Advances,
Год журнала:
2024,
Номер
6, С. 100210 - 100210
Опубликована: Май 1, 2024
Traditional
drug
delivery
techniques
often
have
drawbacks
such
inadequate
bioavailability,
quick
clearance,
and
non-specific
targeting,
which
may
result
in
unfavorable
side
effects.
Hybrid
nanocarriers
composed
of
nanoclay
the
potential
to
be
a
viable
solution
these
problems.
The
goal
this
work
was
design
biocompatible
hybrid
nanocarrier
that
would
release
curcumin
under
regulated
conditions
specific
locations,
especially
cancer
cells.
FTIR,
XRD,
FESEM
were
used
effectively
construct
evaluate
our
polyvinyl
pyrrolidone/polyethylene
glycol/montmorillonite
(PVP/PEG/MMT)
hydrogels,
verifying
their
synthesis
intended
features.
Zeta
DLS
studies
showed
suitable
size
distribution
(∼300
nm)
high
stability.
encapsulation
efficiency
profile
assessed
using
use
UV
spectrophotometry
dialysis
bag
technique.
findings
gradual
continuous
highly
impacted
by
acidic
environment
(which
mimicked
characteristics
cells),
suggesting
pH-responsive
activity.
MTT
test
vitro
cytotoxicity
experiments
show
curcumin-loaded
more
effective
against
MCF-7
cells
than
solution.
Increased
rates
necrosis
apoptosis
treated
with
formulation
further
validated
flowcytometry.
According
results,
PVP/PEG/MMT
hydrogels
lot
as
cutting-edge
strategy
for
curcumin.
They
able
overcome
some
traditional
improve
effectiveness
treatment
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Апрель 4, 2023
Ovarian
cancer
stands
as
the
fifth
most
prevalent
among
women,
causing
more
mortalities
than
any
other
disease
of
female
reproductive
system.
There
are
numerous
histological
subtypes
ovarian
cancer,
each
which
has
distinct
clinical
characteristics,
risk
factors,
cell
origins,
molecular
compositions,
and
therapeutic
options.
Typically,
it
is
identified
at
a
late
stage,
there
no
efficient
screening
method.
Standard
therapies
for
newly
diagnosed
cytoreductive
surgery
platinum-based
chemotherapy.
The
difficulties
traditional
procedures
encourage
researchers
to
search
approaches,
such
nanotechnology.
Due
unique
characteristics
matter
nanoscale,
nanomedicine
emerged
potent
tool
creating
novel
drug
carriers
that
effective
have
fewer
adverse
effects
treatments.
Nanocarriers
including
liposomes,
dendrimers,
polymer
nanoparticles,
micelles
properties
in
surface
chemistry,
morphology,
mechanism
action
can
distinguish
between
malignant
normal
cells,
paving
way
targeted
delivery.
In
contrast
their
non-functionalized
counterparts,
development
functionalized
nano-formulations
with
specific
ligands
permits
selective
targeting
cancers
ultimately
increases
potential.
This
review
focuses
on
application
various
nanomaterials
treatment
diagnosis
advantages
over
conventional
methods,
role
controlled
delivery
systems
therapy
cancer.
Drug Delivery,
Год журнала:
2022,
Номер
29(1), С. 3218 - 3232
Опубликована: Окт. 19, 2022
Formulations
from
nanotechnology
platform
promote
therapeutic
drug
delivery
and
offer
various
advantages
such
as
biocompatibility,
non-inflammatory
effects,
high
output,
biodegradability,
non-toxicity,
biocompatibility
in
comparison
with
free
delivery.
Due
to
inherent
shortcomings
of
conventional
cancerous
tissues,
alternative
nanotechnological-based
approaches
have
been
developed
for
ailments.
Ovarian
cancer
is
the
leading
gynecological
higher
mortality
rates
due
its
reoccurrence
late
diagnosis.
In
recent
years,
field
medical
has
witnessed
significant
progress
addressing
existing
problems
improving
diagnosis
therapy
diseases
including
cancer.
Nevertheless,
literature
current
reviews
on
are
mainly
focused
applications
other
cancers
or
diseases.
this
review,
we
nanoscale
systems
ovarian
targeted
diagnosis,
different
nanocarriers
dendrimers,
nanoparticles,
liposomes,
nanocapsules,
nanomicelles
discussed.
non-functionalized
counterparts
nanoformulations,
potential
preferential
targeting
through
ligand
functionalized
nanoformulations'
development
reviewed.
Furthermore,
numerous
biomarkers
prostatic,
mucin
1,
CA-125,
apoptosis
repeat
baculoviral
inhibitor-5,
human
epididymis
protein-4,
e-cadherin
identified
elucidated
review
assessment
Nanomaterial
biosensor-based
tumor
markers
their
types
explained
article.
association,
nanocarrier
also
underpinned.
To
ensure
control
efficient
detection,
there
an
urgent
need
faster
less
costly
tools
arena
oncology.
