The diverse effects of cisplatin on tumor microenvironment: Insights and challenges for the delivery of cisplatin by nanoparticles

Environmental Research, Год журнала: 2023, Номер 240, С. 117362 - 117362

Опубликована: Окт. 10, 2023

Язык: Английский

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Chemoradiotherapy and nanomedicine: Drug mechanisms and delivery systems

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(4)

Опубликована: Июль 1, 2024

Abstract Radiotherapy is an invaluable tool in the treatment of cancer. However, when used as a monotherapy, it fails to provide curative outcomes. Chemotherapy drugs are often included boost effects radiation. Key classes radiosensitizing include platinum compounds, anthracyclines, antimetabolites, taxanes, topoisomerase inhibitors, alkylating agents, and DNA damage repair inhibitors. Chemoradiotherapy suffers from not only systemic toxicities chemotherapy but also synergistic radiation toxicity well. It critical deliver molecules tumor cells while avoiding adjacent healthy tissues. Currently, nanomedicine provides avenue for specific delivery radiosensitizers. Nanoscale vehicles can be synthesized lipids, polymers, or inorganic materials. Additionally, encompasses stimuli responsive particles including prodrug formulation activation. Clinically, radiotherapy intertwined with approved DOXIL Abraxane. Though many challenges remain, ongoing progress evidences promising future both chemoradiotherapy. This article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Cardiovascular Emerging Technologies

Язык: Английский

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Therapeutic Effect of Cisplatin-Loaded Polymeric Nanoparticles and Nimotuzumab Combination in Human Glioblastoma Cells

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Objective This study evaluated the combined therapeutic effects of cisplatin-loaded PEG-PLGA nanoparticles (CIS-PEG-PLGA) and nimotuzumab (NIMO) on glioblastoma (GBM) cells, focusing their antiproliferative, apoptotic, cell cycle-modulatory effects. Materials Methods were synthesized using a double-emulsion solvent evaporation method, achieving mean particle size ~ 450 nm. Cisplatin release kinetics, proliferation, apoptosis, cycle progression assessed in U87 cells. The treatments included free cisplatin (CIS), CIS-PEG-PLGA, NIMO, combinations. Experiments performed triplicate, statistical analyses ANOVA test. Results CIS-PEG-PLGA exhibited sustained release, with 50% released within 8 h nearly 100% 72 h. combination + NIMO reduced proliferation by 90%, significantly surpassing that CIS (50%) (70%). Apoptosis rates highest group (27.52%), followed (18.59%) (25.95%). Cell analysis revealed significant G2 phase arrest (30.12%) treatment group, highlighting its superior modulatory progression. Conclusion demonstrated synergistic enhancing outcomes. approach represents promising advancement therapy integrating nanotechnology immunotherapy to overcome conventional limitations. Further, vivo studies are warranted validate these findings explore clinical applications.

Язык: Английский

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Quantification of Cisplatin Encapsulated in Nanomedicine: An Overview

Biosensors, Год журнала: 2025, Номер 15(5), С. 293 - 293

Опубликована: Май 6, 2025

Cisplatin, which kills cancer cells mainly through DNA crosslinking, has been widely used as a first-line chemotherapeutic agent although it also causes severe side effects. To improve anticancer outcomes, various types of cisplatin-based nanomedicines have developed, either direct incorporation or coordination cisplatin within nanoparticles (NPs). During the formulation and characterization cisplatin-loaded NPs, quantitative determination is crucial for both clinically newly developed NPs. While NPs facilitate delivery, use different nanomaterials inevitably complicates its increases cost quantification. Currently, there still significant demand an accurate, simple, cost-effective method to determine in would screening quality control nanomedicines. This review aims discuss main strategies quantifying cisplatin, following summary Application examples are provided, key features each quantification strategy compared. In addition, NP-based electrochemical sensors included emerging approach characterizing loaded Rational selection appropriate according principle specific drug-delivery settings highly recommended.

Язык: Английский

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Effects of Chitosan on Drug Load and Release for Cisplatin–Hydroxyapatite–Gelatin Composite Microspheres

Polymers, Год журнала: 2025, Номер 17(11), С. 1485 - 1485

Опубликована: Май 27, 2025

Cisplatin, a widely used chemotherapeutic agent, is limited by its poor bioavailability, rapid systemic clearance, and severe side effects. To overcome these limitations, hydroxyapatite–gelatin composite microspheres were developed to improve drug entrapment efficiency (DEE) provide sustained release. Various formulations prepared incorporating chitosan either mixing once or through sequential coating strategy. By adjusting the loading procedure, DEE increased from 58% 99%. The microsphere effectively controlled total release duration, extending it one month over 5 months. Moreover, MTT assay demonstrated that all samples inhibited cell growth, with viability reduced less than 20% after 2 weeks of experimentation. These findings demonstrate method offers superior prolonged compared once, exhibiting potential as delivery system for cancer treatment.

Язык: Английский

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Vanadium ferrite-doped mesoporous bioactive glass-ceramics: controlled cisplatin delivery in chemohyperthermia

RSC Advances, Год журнала: 2025, Номер 15(23), С. 18657 - 18669

Опубликована: Янв. 1, 2025

This study explores the multifunctional application of vanadium ferrite-doped mesoporous bioactive glass-ceramics (MBGCs), presenting a novel approach to synergistically integrate chemohyperthermia and controlled cisplatin delivery in cancer treatment. Using sol-gel method, MBGC formulations were developed, which VF0510 (a formulation containing 5 mol% V2O5 10 Fe2O3) identified as optimal composition due its superior magnetic properties, bioactivity, drug capabilities. The previously established architecture VF0510, validated our earlier study, enabled effective loading sustained release this work. Calorimetric analyses revealed that achieved therapeutic temperature 41.5 °C under an alternating field, meeting range for hyperthermia-based treatments. Drug studies demonstrated hydroxypropyl cellulose (HPC)-coated provided 68% over 48 hours, significantly reducing burst effect while maintaining prolonged action. In vitro assays using MG63 osteosarcoma cells statistically significant results (P < 0.01), with cisplatin-loaded cell viability by 45% within hours through apoptosis induction, confirmed flow cytometry. dual-modality platform integrates localized hyperthermia chemotherapy delivery, addressing challenges such systemic toxicity resistance. highlight critical role ferrite enhancing response HPC coating ensures efficient release. Future research should optimize thermoresponsive properties polymer coatings validate findings vivo models, paving way safer, more therapies combining chemotherapy.

Язык: Английский

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Polyoxometalates immobilized on MIL-100 (Fe) as an emerging platform for eliminating breast cancer tumor cells

Results in Chemistry, Год журнала: 2023, Номер 5, С. 100857 - 100857

Опубликована: Янв. 1, 2023

Polyoxometalates (POMs) have shown promising antitumor activities attributed to their virtue of incomparable structural versatility and interesting redox properties. However, the clinical application POM drugs is limited by poor stability low anticancer specificity. To overcome these shortcomings, a multifunctional platform based on POMs (the tetrabutylammonium salts [PW12O40]3−, [V10O28H3]3− [Mo6O19]2−) MIL-100 (Fe) was successfully developed for combined chemical chemodynamic therapy, ultimately inducing cancer cell apoptosis. The prepared POMs@MIL-100 composites showed great efficiency in killing MCF-7 4T1 cells while with toxicity normal MCF-10A C2C12 cells.

Язык: Английский

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A comprehensive review on niosomes: novel manufacturing techniques, factors influencing formation, applications and recent advances

International Journal of Polymeric Materials, Год журнала: 2024, Номер unknown, С. 1 - 18

Опубликована: Ноя. 18, 2024

A huge variety of drugs having varying therapeutic effects can be encapsulated into niosomes and delivered to patients in an efficient way. These nonionic vesicles form a double layer fluid media, enhancing bioavailability. Niosomes prepared using various methods such as the Reverse Phase Evaporation Technique, Ether Injection Method, Bubble Microfluidization, Hand Shaking Sonication, Multiple Membrane Extrusion Niosome Formation from Proniosomes. are used applications, including targeting bioactive substances, neoplasia, diagnostic imaging ophthalmic drug delivery system. Advancement will results development smart-stimuli niosomal system that inhibits ovarian cancer cells, MCF10-A cells by biofunctionalizing curcumin, with potential for more potent tumor-inhibitory effects. It also lead formation thermo-responsive Pluronic® L64 L64ox nanosilica substrate HER2-positive breast treatment. This review aims analyze novel manufacturing techniques, factors influencing formation, applications delivery, highlighting their stability, bioavailability, targeted advantages. explores recent advancements, responsive systems disease

Язык: Английский

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Folate receptor-targeted thiol-maleimide clicked chitosan/carboxymethyl cellulose nanoparticles for cisplatin delivery in oral carcinoma

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138976 - 138976

Опубликована: Дек. 1, 2024

Язык: Английский

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Enhancement of Tumor Cell Immunogenicity and Antitumor Properties Derived from Platinum-Conjugated Iron Nanoparticles

Cancers, Год журнала: 2023, Номер 15(12), С. 3204 - 3204

Опубликована: Июнь 15, 2023

From chemistry design to clinical application, several approaches have been developed overcome platinum drawbacks in antitumoral therapies. An in-depth understanding of intracellular signaling may hold the key relationship both conventional drugs and nanoparticles. Within these strategies, first, nanotechnology has become an essential tool oncotherapy, improving biopharmaceutical properties providing new immunomodulatory profiles mediated by activation endoplasmic reticulum (ER) stress. Secondly, functional proteomics techniques based on microarrays proven be a successful method for high throughput screening proteins profiling biomolecule mechanisms action. Here, we conducted systematic characterization antitumor profile compound conjugated with iron oxide nanoparticles (IONPs). As result nano-conjugation, cytotoxic revealed significant improvement starting material, selectivity certain tumor cell lines tested. Moreover, death patterns associated immunogenic (ICD) response also identified when ER pathways triggered. The evaluation analysis shown novel perspectives cisplatin-derived conjugates, value IONPs as drug delivery systems ICD rewarding approach targeted oncotherapy onco-immunotherapies.

Язык: Английский

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