Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Окт. 28, 2024
is
a
medicinal
plant
widely
studied
due
to
its
great
phytochemical
diversity,
especially
acrinonic
alkaloids,
which
have
shown
be
promising
anticancer
candidates.
The
aim
of
this
work
was
promote
the
isolation
acridonic
alkaloids
from
fruits
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(4)
Опубликована: Июль 1, 2024
Abstract
Radiotherapy
is
an
invaluable
tool
in
the
treatment
of
cancer.
However,
when
used
as
a
monotherapy,
it
fails
to
provide
curative
outcomes.
Chemotherapy
drugs
are
often
included
boost
effects
radiation.
Key
classes
radiosensitizing
include
platinum
compounds,
anthracyclines,
antimetabolites,
taxanes,
topoisomerase
inhibitors,
alkylating
agents,
and
DNA
damage
repair
inhibitors.
Chemoradiotherapy
suffers
from
not
only
systemic
toxicities
chemotherapy
but
also
synergistic
radiation
toxicity
well.
It
critical
deliver
molecules
tumor
cells
while
avoiding
adjacent
healthy
tissues.
Currently,
nanomedicine
provides
avenue
for
specific
delivery
radiosensitizers.
Nanoscale
vehicles
can
be
synthesized
lipids,
polymers,
or
inorganic
materials.
Additionally,
encompasses
stimuli
responsive
particles
including
prodrug
formulation
activation.
Clinically,
radiotherapy
intertwined
with
approved
DOXIL
Abraxane.
Though
many
challenges
remain,
ongoing
progress
evidences
promising
future
both
chemoradiotherapy.
This
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease
Cardiovascular
Emerging
Technologies
Biosensors,
Год журнала:
2025,
Номер
15(5), С. 293 - 293
Опубликована: Май 6, 2025
Cisplatin,
which
kills
cancer
cells
mainly
through
DNA
crosslinking,
has
been
widely
used
as
a
first-line
chemotherapeutic
agent
although
it
also
causes
severe
side
effects.
To
improve
anticancer
outcomes,
various
types
of
cisplatin-based
nanomedicines
have
developed,
either
direct
incorporation
or
coordination
cisplatin
within
nanoparticles
(NPs).
During
the
formulation
and
characterization
cisplatin-loaded
NPs,
quantitative
determination
is
crucial
for
both
clinically
newly
developed
NPs.
While
NPs
facilitate
delivery,
use
different
nanomaterials
inevitably
complicates
its
increases
cost
quantification.
Currently,
there
still
significant
demand
an
accurate,
simple,
cost-effective
method
to
determine
in
would
screening
quality
control
nanomedicines.
This
review
aims
discuss
main
strategies
quantifying
cisplatin,
following
summary
Application
examples
are
provided,
key
features
each
quantification
strategy
compared.
In
addition,
NP-based
electrochemical
sensors
included
emerging
approach
characterizing
loaded
Rational
selection
appropriate
according
principle
specific
drug-delivery
settings
highly
recommended.
Polymers,
Год журнала:
2025,
Номер
17(11), С. 1485 - 1485
Опубликована: Май 27, 2025
Cisplatin,
a
widely
used
chemotherapeutic
agent,
is
limited
by
its
poor
bioavailability,
rapid
systemic
clearance,
and
severe
side
effects.
To
overcome
these
limitations,
hydroxyapatite–gelatin
composite
microspheres
were
developed
to
improve
drug
entrapment
efficiency
(DEE)
provide
sustained
release.
Various
formulations
prepared
incorporating
chitosan
either
mixing
once
or
through
sequential
coating
strategy.
By
adjusting
the
loading
procedure,
DEE
increased
from
58%
99%.
The
microsphere
effectively
controlled
total
release
duration,
extending
it
one
month
over
5
months.
Moreover,
MTT
assay
demonstrated
that
all
samples
inhibited
cell
growth,
with
viability
reduced
less
than
20%
after
2
weeks
of
experimentation.
These
findings
demonstrate
method
offers
superior
prolonged
compared
once,
exhibiting
potential
as
delivery
system
for
cancer
treatment.
RSC Advances,
Год журнала:
2025,
Номер
15(23), С. 18657 - 18669
Опубликована: Янв. 1, 2025
This
study
explores
the
multifunctional
application
of
vanadium
ferrite-doped
mesoporous
bioactive
glass-ceramics
(MBGCs),
presenting
a
novel
approach
to
synergistically
integrate
chemohyperthermia
and
controlled
cisplatin
delivery
in
cancer
treatment.
Using
sol-gel
method,
MBGC
formulations
were
developed,
which
VF0510
(a
formulation
containing
5
mol%
V2O5
10
Fe2O3)
identified
as
optimal
composition
due
its
superior
magnetic
properties,
bioactivity,
drug
capabilities.
The
previously
established
architecture
VF0510,
validated
our
earlier
study,
enabled
effective
loading
sustained
release
this
work.
Calorimetric
analyses
revealed
that
achieved
therapeutic
temperature
41.5
°C
under
an
alternating
field,
meeting
range
for
hyperthermia-based
treatments.
Drug
studies
demonstrated
hydroxypropyl
cellulose
(HPC)-coated
provided
68%
over
48
hours,
significantly
reducing
burst
effect
while
maintaining
prolonged
action.
In
vitro
assays
using
MG63
osteosarcoma
cells
statistically
significant
results
(P
<
0.01),
with
cisplatin-loaded
cell
viability
by
45%
within
hours
through
apoptosis
induction,
confirmed
flow
cytometry.
dual-modality
platform
integrates
localized
hyperthermia
chemotherapy
delivery,
addressing
challenges
such
systemic
toxicity
resistance.
highlight
critical
role
ferrite
enhancing
response
HPC
coating
ensures
efficient
release.
Future
research
should
optimize
thermoresponsive
properties
polymer
coatings
validate
findings
vivo
models,
paving
way
safer,
more
therapies
combining
chemotherapy.
Results in Chemistry,
Год журнала:
2023,
Номер
5, С. 100857 - 100857
Опубликована: Янв. 1, 2023
Polyoxometalates
(POMs)
have
shown
promising
antitumor
activities
attributed
to
their
virtue
of
incomparable
structural
versatility
and
interesting
redox
properties.
However,
the
clinical
application
POM
drugs
is
limited
by
poor
stability
low
anticancer
specificity.
To
overcome
these
shortcomings,
a
multifunctional
platform
based
on
POMs
(the
tetrabutylammonium
salts
[PW12O40]3−,
[V10O28H3]3−
[Mo6O19]2−)
MIL-100
(Fe)
was
successfully
developed
for
combined
chemical
chemodynamic
therapy,
ultimately
inducing
cancer
cell
apoptosis.
The
prepared
POMs@MIL-100
composites
showed
great
efficiency
in
killing
MCF-7
4T1
cells
while
with
toxicity
normal
MCF-10A
C2C12
cells.
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 18
Опубликована: Ноя. 18, 2024
A
huge
variety
of
drugs
having
varying
therapeutic
effects
can
be
encapsulated
into
niosomes
and
delivered
to
patients
in
an
efficient
way.
These
nonionic
vesicles
form
a
double
layer
fluid
media,
enhancing
bioavailability.
Niosomes
prepared
using
various
methods
such
as
the
Reverse
Phase
Evaporation
Technique,
Ether
Injection
Method,
Bubble
Microfluidization,
Hand
Shaking
Sonication,
Multiple
Membrane
Extrusion
Niosome
Formation
from
Proniosomes.
are
used
applications,
including
targeting
bioactive
substances,
neoplasia,
diagnostic
imaging
ophthalmic
drug
delivery
system.
Advancement
will
results
development
smart-stimuli
niosomal
system
that
inhibits
ovarian
cancer
cells,
MCF10-A
cells
by
biofunctionalizing
curcumin,
with
potential
for
more
potent
tumor-inhibitory
effects.
It
also
lead
formation
thermo-responsive
Pluronic®
L64
L64ox
nanosilica
substrate
HER2-positive
breast
treatment.
This
review
aims
analyze
novel
manufacturing
techniques,
factors
influencing
formation,
applications
delivery,
highlighting
their
stability,
bioavailability,
targeted
advantages.
explores
recent
advancements,
responsive
systems
disease
Cancers,
Год журнала:
2023,
Номер
15(12), С. 3204 - 3204
Опубликована: Июнь 15, 2023
From
chemistry
design
to
clinical
application,
several
approaches
have
been
developed
overcome
platinum
drawbacks
in
antitumoral
therapies.
An
in-depth
understanding
of
intracellular
signaling
may
hold
the
key
relationship
both
conventional
drugs
and
nanoparticles.
Within
these
strategies,
first,
nanotechnology
has
become
an
essential
tool
oncotherapy,
improving
biopharmaceutical
properties
providing
new
immunomodulatory
profiles
mediated
by
activation
endoplasmic
reticulum
(ER)
stress.
Secondly,
functional
proteomics
techniques
based
on
microarrays
proven
be
a
successful
method
for
high
throughput
screening
proteins
profiling
biomolecule
mechanisms
action.
Here,
we
conducted
systematic
characterization
antitumor
profile
compound
conjugated
with
iron
oxide
nanoparticles
(IONPs).
As
result
nano-conjugation,
cytotoxic
revealed
significant
improvement
starting
material,
selectivity
certain
tumor
cell
lines
tested.
Moreover,
death
patterns
associated
immunogenic
(ICD)
response
also
identified
when
ER
pathways
triggered.
The
evaluation
analysis
shown
novel
perspectives
cisplatin-derived
conjugates,
value
IONPs
as
drug
delivery
systems
ICD
rewarding
approach
targeted
oncotherapy
onco-immunotherapies.