Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 242, С. 114082 - 114082
Опубликована: Июль 15, 2024
Язык: Английский
Reactive and Functional Polymers, Год журнала: 2024, Номер 196, С. 105841 - 105841
Опубликована: Янв. 26, 2024
Applications of sodium alginate (Alg) and polyacrylic acid (PAA) hydrogels in biomedicine are well-known. These predefined by the strength weakness their properties, which turn depend on chemical structure architecture crosslinks. In this work, Alg biopolymer has been grafted to synthetic PAA that chemically crosslinked using N,N′-methylene-bisacrylamide (MBA) produce a pH responsive hydrogel with adhesive property. The double crosslinking network, combines MBA-mediated covalent crosslinks ionic domains, results an elastic modulus resembles highly anisotropic viscoelastic human skin. After addressing influence dual network onto Alg-g-PAA prospection its potential as made considering different surfaces (rubber, paper steel, porcine skin, etc). bonding energy 32.6 ± 4.6 J/m2, revealed can be proposed biomedical field tissue for wound healing applications. Finally, semi-interpenetrated poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PEDOT-MeOH) chains through oxidative polymerization process. resulting hydrogel, Alg-g-PAA/PEDOT-MeOH, is even more porous than Alg-g-PAA, addition being electro-responsive, maintains properties.
Язык: Английский
Процитировано
5
The Canadian Journal of Chemical Engineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 26, 2025
Abstract Bacterial cellulose (BC), a biopolymer with unique properties, has been employed in numerous biomedical applications. Carboxymethyl was introduced to the agitated culture of Gluconacetobacter xylinus produce pH‐responsive BC hydrogel beads. It shown by x‐ray diffraction (XRD) analysis that adding carboxymethyl increased crystallinity Scanning electron microscopy exhibited 3‐D porous structure microfibrils and reverse effect on hydrogels' porosity. The hydrogels were loaded ibuprofen sodium salt (IbuNa), their release swelling studies conducted simulated gastric intestinal fluids. observed increasing amount medium, pH responsivity beads increased. Thus, this study shows potential BC/CMC system as an oral drug delivery system.
Язык: Английский
Процитировано
0
Journal of Bionic Engineering, Год журнала: 2025, Номер unknown
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
0
Journal of Materials Research and Technology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(4)
Опубликована: Апрель 1, 2025
ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.
Язык: Английский
Процитировано
0
Inorganic Chemistry Communications, Год журнала: 2023, Номер 159, С. 111814 - 111814
Опубликована: Ноя. 29, 2023
Язык: Английский
Процитировано
11
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140822 - 140822
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 48, С. 370 - 399
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
0
Macromolecular Bioscience, Год журнала: 2025, Номер unknown
Опубликована: Март 25, 2025
The current use of fertilizers is inefficient and not sustainable. majority the fertilizer applied does reach targeted crop but lost in water bodies into atmosphere, with harmful impact on environment. To enhance efficiency sustainability agricultural practices, it essential to address two complementary challenges. First, nutrient delivery methods must be refined maximize plant uptake. Second, recovery nutrients from wastewater other waste streams should improved recycling nitrogen phosphorous reduce environmental pollution. Biodegradable polymers hold great promise for development technological solutions toward more sustainable practices. This review covers application biodegradable both aspects cycle: plants through slow- controlled-release fertilizers, using membrane separation, adsorbent composites, coagulants/flocculants. most promising materials are highlighted approaches, identifying research gaps discussing potential future directions this highly significant field.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(48), С. 55201 - 55231
Опубликована: Ноя. 23, 2023
The nanomaterial and related toolkit have promising applications for improving human health well-being. Nanobased drug delivery systems use nanoscale materials as carriers to deliver therapeutic agents in a targeted controlled manner, they shown potential address issues associated with conventional systems. They offer benefits treating various illnesses by encapsulating or conjugating biological agents, chemotherapeutic drugs, immunotherapeutic agents. of this technology are vast; however, significant challenges exist overcome such safety issues, toxicity, efficacy, insufficient capacity. This article discusses the latest developments systems, including release mechanisms, material toolkits, design molecules, parameters. concluding section examines limitations provides insights into future possibilities.
Язык: Английский
Процитировано
10