An Updated Overview of Silica Aerogel-Based Nanomaterials

Nanomaterials, Год журнала: 2024, Номер 14(5), С. 469 - 469

Опубликована: Март 4, 2024

Silica aerogels have gained much interest due to their unique properties, such as being the lightest solid material, having small pore sizes, high porosity, and ultralow thermal conductivity. Also, advancements in synthesis methods enabled creation of silica aerogel-based composites combination with different materials, for example, polymers, metals, carbon-based structures. These new silica-based materials combine properties other create a reinforced architecture significantly valuable uses fields. Therefore, importance has been emphasized by presenting process, composites, numerous applications, offering an updated background further research this interdisciplinary domain.

Язык: Английский

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Aspergillus oryzae β-D-galactosidase immobilization on glutaraldehyde pre-activated amino-functionalized magnetic mesoporous silica: Performance, characteristics, and application in the preparation of sesaminol

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132101 - 132101

Опубликована: Май 10, 2024

Язык: Английский

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Hybrid nanoarchitecture of gelatin-modified silica-chitosan as an efficient delivery platform and functional role of crosslinking

International Journal of Polymeric Materials, Год журнала: 2023, Номер 73(15), С. 1291 - 1304

Опубликована: Ноя. 15, 2023

A novel hybrid of a quercetin-loaded silica-chitosan, modified by crosslinked gelatin-folate was developed in the current study as pH-sensitive drug delivery system. The entrapment efficiency quercetin measured at about 77%. release pattern investigated acidic and natural media (pH 5.6 pH = 7.4) for 96 h. In-vitro from unmodified carriers exhibited rapid early times (57 39% after 24 h neutral media), which followed slower release. However, behavior improved modifying carrier with layer. In addition, further rate observed gelatin-modified an medium (31% h) compared to condition (20% h), confirming behavior. Furthermore, cumulative silica-chitosan approximately slow release, so that 23% 15% released conditions, respectively. date described Higuchi model, suggesting both diffusion polymer swelling control process. high loading, pH-triggered behavior, controlled platform, combined low toxicity, render this designed applicable targeted delivery.

Язык: Английский

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Surface Engineering and Optimizing DepoFoam System: A Robust Quality by Design Approach for Optimal Drug Delivery, Stability, and Quality

Journal of Pharmaceutical Innovation, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 18, 2024

Язык: Английский

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Efficient surface modification of silica-alginate nanocarrier as smart drug release platform

Journal of Dispersion Science and Technology, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Апрель 11, 2024

A hybrid nanocarrier based on silica-alginate modified by gelatin-folic acid was designed as a pH-sensitive drug delivery system and investigated in the terms of amount doxorubicin loading release behavior two different mediums with pH 7.4 5.6. The content entrapment efficiency were measured at about 21% 67%, respectively. results showed rapid from unmodified carrier initial times (first 24 h). While use gelatin-folate modification led to improvement behavior. Here, released after 72 h neutral acidic environment 82% 73%, using gelatin modification, decreased 71% 63%. These show that prepared is sensitive pH. Furthermore, cross-linking effect modifier layer pattern indicated both natural media. findings this research appropriate performance carriers for delivery.

Язык: Английский

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Folate-targeted albumin modified silica-gelatin hybrid nanocarrier involving synthesis and release characterization

Journal of Porous Materials, Год журнала: 2024, Номер 31(6), С. 2165 - 2175

Опубликована: Июль 30, 2024

Язык: Английский

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One-Pot Preparation of HCPT@IRMOF-3 Nanoparticles for pH-Responsive Anticancer Drug Delivery

Molecules, Год журнала: 2023, Номер 28(23), С. 7703 - 7703

Опубликована: Ноя. 22, 2023

Metal–organic frameworks (MOFs) are considered to be promising materials for drug delivery. In this work, a Zinc-based MOF nanocomposite IRMOF-3 was introduced as carrier 10-hydroxycamptothecine (HCPT). Without an extra drug-loading process, nanoscale delivery material HCPT@IRMOF-3 prepared via one-pot synthesis. The composition and structure of the were investigated, release character measured. Compared with preparing first loading drug, one-pot-prepared exhibited higher capacity. presented pH-responsive release. HCPT rate at pH 5.0 significantly than that 7.4. cytotoxicity experiments showed non-toxic, notable Hela SH-SY5Y cells. One-pot synthesis is simple rapid method preparation system, can potentially used in systems.

Язык: Английский

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Design Principles for Smart Linear Polymer Ligand Carriers with Efficient Transcellular Transport Capabilities

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 6826 - 6826

Опубликована: Июнь 21, 2024

The surface functionalization of polymer-mediated drug/gene delivery holds immense potential for disease therapy. However, the design principles underlying polymers remain elusive. In this study, we employed computer simulations to demonstrate how stiffness, length, density, and distribution polymer ligands influence their penetration ability across cell membrane. Our revealed that stiffness affects transport cargo Increasing can promote membrane, particularly larger cargoes. Furthermore, appropriately increasing length be more conducive assisting enter lower layer Additionally, on also plays a crucial role in its transport. Specifically, one-fourth mode stripy distributions exhibited higher ability, cargoes penetrating These findings provide biomimetic inspiration designing high-efficiency delivery.

Язык: Английский

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Folate-targeted albumin modified silica-gelatin hybrid nanocarrier. Synthesis and release characterization

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 31, 2024

A novel hybrid of BSA-folate modified silica-gelatin nanocarrier with surface area about 422 m²/g was designed in the current study and loaded by fluorouracil 70 % entrapment efficiency. The evaluated terms pH-sensitive release behavior simulated acidic condition cancer tissue (pH=5.), normal physiological body (pH=7.4) for 96 h. In vitro drug from nanocarriers indicated a partial burst early times (34 21 after 12 h neutral media), which followed sustained gradual profile until addition, an enhanced observed at pH (65 h) compared to natural medium (42 h), confirming pH-responsive developed nanocarrier. MTT assay showed low toxicity drug-free carrier against HDF fibroblast, OVCAR-3 ovarian cells. These outcomes support proper function targeted delivery.

Язык: Английский

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Application of Modified Silica as an Efficient Slow-Release Carrier Medium: A Review

Key engineering materials, Год журнала: 2024, Номер 990, С. 59 - 74

Опубликована: Окт. 29, 2024

The use of mesoporous material as a carrier is increasingly gaining significant attention in recent years. often exists the form organic polymers, including chitosan and starch-g-poly (L-lactide), well inorganic substances, namely zeolites, sulfur, silica. In this context, silica has greatest abundance nature extensively applied medium due to its high selectivity, excellent regeneration ability, environmental friendliness. However, shows some limitations, such surface tension large inter-particle bonding forces, which can be addressed through modifications area pore size by adding surfactants. will transform into structure, suitable for slow-release various applications, catalysts, sensors, adsorbents, chromatography, drug delivery systems, intelligent corrosion inhibitors.

Язык: Английский

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