Heliyon,
Год журнала:
2024,
Номер
10(16), С. e36152 - e36152
Опубликована: Авг. 1, 2024
The
biomedical
application
of
biodegradable
polymers
for
addressing
bone-related
diseases
has
garnered
considerable
attention
in
recent
years.
Advances
material
technology
have
expanded
the
repertoire
materials
suitable
orthopedic
implants,
with
nanomaterials
playing
a
pivotal
role
replicating
crucial
surface
properties
akin
to
natural
tissues.
This
comprehensive
review
explores
evaluation
bioactive
glass
ceramics,
shedding
light
on
their
and
applications.
synthesis
composites
through
composite
manufacturing
emerged
as
strategy
enhance
biocompatibility
biomechanical
characteristics.
They
are
challenges
associated
conventional
implants
nanomaterials,
whether
form
functional
nano
coatings
or
nanostructured
surfaces,
present
opportunities
refine
implant
techniques.
Novel
developments
biomaterials,
such
smart
porous
structures,
3D
offer
stimuli-responsive
behavior
achieve
desired
shapes
Bioactive
polymer/inorganic
explored
bone
tissue
engineering
scaffolds,
aiming
promote
formation
regeneration.
As
prospective
direction,
integration
stem
cells
into
scaffolds
hints
at
creation
next-generation
synthetic/living
hybrid
displaying
high
adaptability
biological
settings.
establishes
foundation
nanotechnology-driven
biomaterials
by
elucidating
fundamental
design
factors
performance
response
cell
differentiation,
proliferation,
adhesion.
Journal of Inorganic and Organometallic Polymers and Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 16, 2024
Abstract
Polymer
nanocomposites
are
promising
materials
for
various
applications
in
the
electronics,
biomedicine,
and
aerospace
industries.
However,
fabrication
errors
or
defects,
e.g.,
induced
porosity,
significantly
impact
performance
reliability
of
devices
fabricated
from
polymer
nanocomposites.
Hence,
this
study
has
comprehensively
carried
out
an
investigation
into
effects
defects
on
properties
photovoltaic
active
cells,
biomimetic
scaffold,
aircraft
structures
that
by
using
Agglomeration
is
another
defect
degrades
intended
nanocomposite
devices.
For
devices,
can
be
controlled
selective
modification
organic
semiconductor
molecular
structures.
In
addition,
proper
optimization
process
parameters
material
selection,
effective
approaches
obtaining
excellent
cells.
Furthermore,
presence
impurities,
a
non-homogeneous
mixture
inorganic
materials,
incomplete
solubility
nanoparticles,
detrimental
factors
affect
cell
proliferation
scaffolds.
These
technological
imperfections
must
also
avoided
when
producing
parts
other
words,
impurities
introduced
during
synthesis
processing
stages
lead
to
irregularities
structure,
which
often
its
mechanical,
electrical,
biomedical,
optical
properties.
The
understanding
mitigating
these
crucial
applications.
Composites Science and Technology,
Год журнала:
2023,
Номер
243, С. 110263 - 110263
Опубликована: Сен. 20, 2023
Replicating
the
natural
cellular
environment
is
a
critical
strategy
when
employing
biomaterials
to
enhance
tissue
regeneration.
However,
effectively
controlling
physical
cues,
including
electrical
and
mechanical
stimuli,
in
extracellular
microenvironment
promote
regeneration,
remains
challenging
endeavor.
This
study
presents
technological
utilization
of
magnetoelectric
(ME)
composites,
capable
delivering
stimuli
through
remote
activation
using
magnetic
field,
for
applications
bone-related
engineering.
Poly(vinylidene
fluoride-co-trifluoroethylene)
scaffolds
incorporating
two
types
magnetostrictive
particles,
namely
Terfenol-D
(TD)
microparticles
CoFe2O4
(CFO)
nanoparticles,
were
used
investigate
impact
mechano-electrical
on
preosteoblast
cells.
The
results
demonstrate
that
such
are
applied
custom-made
bioreactor,
both
proliferation
rate
mineralization
increase.
Such
outcomes
dependent
specific
particles
incorporated
composite.
These
findings
underscore
significance
designing
properties
ME
active
achieve
successful
bone
Thus,
presented
emulate
microenvironment,
enabling
precise,
controlled,
effective
regenerative
therapies
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
95, С. 105582 - 105582
Опубликована: Март 13, 2024
Combining
a
hydrophobic
polymer
such
as
polycaprolactone
(PCL)
with
hydrophilic
polyethylene
oxide
(PEO)
in
binary
system
can
enable
range
of
novel
applications
biomedical
engineering
by
permitting
exceptional
therapeutic
release,
antimicrobial
possibilities,
and
heterogeneous
tissue
scaffolds.
In
this
work,
both
PCL
PEO
were
dissolved
chloroform
at
15
w/v
%
six
different
ratios
to
prepare
solutions.
The
rheological
properties
the
singular
solutions
measured,
fibers
spun
using
pressurized
gyration.
fiber
morphologies
prepared
materials
studied
scanning
electron
microscopy
(SEM).
By
immersing
samples
deionized
water,
polymeric
varying
swelling
behaviors
developed
analyzed
optical
microscopy.
results
used
identify
an
optimum
PCL:PEO
mixture
chloroform.
Chemical
compositions
singular/binary
composites
loaded
Ibuprofen
(IBP)
characterized
Fourier-transform
infrared
spectroscopy
(FTIR)
thermal
analysis
was
examined
differential
calorimetry
(DSC).
vitro
studies
on
PEO–IBP
exhibited
instant
release
rate
90
40
s,
whereas
PCL–IBP
PCL:PEO–IBP
revealed
sustained
87–96
72
h,
respectively.
discuss
potential
use
systems
applications.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(7), С. 4270 - 4292
Опубликована: Июль 1, 2024
Bone,
a
fundamental
constituent
of
the
human
body,
is
vital
scaffold
for
support,
protection,
and
locomotion,
underscoring
its
pivotal
role
in
maintaining
skeletal
integrity
overall
functionality.
However,
factors
such
as
trauma,
disease,
or
aging
can
compromise
bone
structure,
necessitating
effective
strategies
regeneration.
Traditional
approaches
often
lack
biomimetic
environments
conducive
to
efficient
tissue
repair.
Nanofibrous
microspheres
(NFMS)
present
promising
platform
regeneration
by
mimicking
native
extracellular
matrix
architecture.
Through
optimized
fabrication
techniques
incorporation
active
biomolecular
components,
NFMS
precisely
replicate
nanostructure
biochemical
cues
essential
osteogenesis
promotion.
Furthermore,
exhibit
versatile
properties,
including
tunable
morphology,
mechanical
strength,
controlled
release
kinetics,
augmenting
their
suitability
tailored
engineering
applications.
enhance
cell
recruitment,
attachment,
proliferation,
while
promoting
osteogenic
differentiation
mineralization,
thereby
accelerating
healing.
This
review
highlights
engineering,
elucidating
design
principles
key
attributes.
By
examining
recent
preclinical
applications,
we
assess
current
clinical
status
discuss
critical
considerations
potential
translation.
offers
crucial
insights
researchers
at
intersection
biomaterials
highlighting
developments
this
expanding
field.
