Heliyon,
Год журнала:
2024,
Номер
10(16), С. e36152 - e36152
Опубликована: Авг. 1, 2024
The
biomedical
application
of
biodegradable
polymers
for
addressing
bone-related
diseases
has
garnered
considerable
attention
in
recent
years.
Advances
material
technology
have
expanded
the
repertoire
materials
suitable
orthopedic
implants,
with
nanomaterials
playing
a
pivotal
role
replicating
crucial
surface
properties
akin
to
natural
tissues.
This
comprehensive
review
explores
evaluation
bioactive
glass
ceramics,
shedding
light
on
their
and
applications.
synthesis
composites
through
composite
manufacturing
emerged
as
strategy
enhance
biocompatibility
biomechanical
characteristics.
They
are
challenges
associated
conventional
implants
nanomaterials,
whether
form
functional
nano
coatings
or
nanostructured
surfaces,
present
opportunities
refine
implant
techniques.
Novel
developments
biomaterials,
such
smart
porous
structures,
3D
offer
stimuli-responsive
behavior
achieve
desired
shapes
Bioactive
polymer/inorganic
explored
bone
tissue
engineering
scaffolds,
aiming
promote
formation
regeneration.
As
prospective
direction,
integration
stem
cells
into
scaffolds
hints
at
creation
next-generation
synthetic/living
hybrid
displaying
high
adaptability
biological
settings.
establishes
foundation
nanotechnology-driven
biomaterials
by
elucidating
fundamental
design
factors
performance
response
cell
differentiation,
proliferation,
adhesion.
Journal of Materials Research and Technology,
Год журнала:
2024,
Номер
30, С. 3101 - 3111
Опубликована: Апрель 9, 2024
Polylactic
acid
(PLA)
and
hydroxyapatite
(HA)
composite
scaffolds
have
been
widely
studied
for
applications
in
bone
tissue
engineering
(BTE)
due
to
their
bioactive
biocompatible
properties.
However,
there
is
a
need
more
knowledge
about
the
influence
of
size
crystallinity
HA
nanoparticles
(nHA)
on
properties
PLA/nHA
nanocomposite
produced
by
3D
printing.
In
this
study,
printing
was
used
produce
PLA
incorporated
with
nHA
filler
different
particle
sizes
crystallinities.
Initially,
nanocomposites
were
prepared
casting
scaffolds,
which
characterized
analysis
thermal,
morphological,
physical-chemical,
mechanical,
biological
vitro.
The
results
showed
that
particles
mainly
influenced
scaffolds'
mechanical
properties,
degradation
rate,
bioactivity.
Incorporating
provided
gain
compressive
strength
compared
pure
PLA,
superior
natural
cancellous
bone,
varies
between
2
12
MPa.
lower
crystallinity,
39.46
%,
promoted
higher
rate
bioactivity
vitro
its
solubility
simulated
fluid.
All
cell
viability
above
90
%.
suitable
BTE
applications.
Heliyon,
Год журнала:
2024,
Номер
10(16), С. e36152 - e36152
Опубликована: Авг. 1, 2024
The
biomedical
application
of
biodegradable
polymers
for
addressing
bone-related
diseases
has
garnered
considerable
attention
in
recent
years.
Advances
material
technology
have
expanded
the
repertoire
materials
suitable
orthopedic
implants,
with
nanomaterials
playing
a
pivotal
role
replicating
crucial
surface
properties
akin
to
natural
tissues.
This
comprehensive
review
explores
evaluation
bioactive
glass
ceramics,
shedding
light
on
their
and
applications.
synthesis
composites
through
composite
manufacturing
emerged
as
strategy
enhance
biocompatibility
biomechanical
characteristics.
They
are
challenges
associated
conventional
implants
nanomaterials,
whether
form
functional
nano
coatings
or
nanostructured
surfaces,
present
opportunities
refine
implant
techniques.
Novel
developments
biomaterials,
such
smart
porous
structures,
3D
offer
stimuli-responsive
behavior
achieve
desired
shapes
Bioactive
polymer/inorganic
explored
bone
tissue
engineering
scaffolds,
aiming
promote
formation
regeneration.
As
prospective
direction,
integration
stem
cells
into
scaffolds
hints
at
creation
next-generation
synthetic/living
hybrid
displaying
high
adaptability
biological
settings.
establishes
foundation
nanotechnology-driven
biomaterials
by
elucidating
fundamental
design
factors
performance
response
cell
differentiation,
proliferation,
adhesion.
