BioNanoScience, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 8, 2025
Язык: Английский
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 39, С. 101299 - 101299
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
28
Nano TransMed, Год журнала: 2024, Номер 3, С. 100040 - 100040
Опубликована: Июнь 27, 2024
Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.
Язык: Английский
Процитировано
24
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 127091 - 127091
Опубликована: Сен. 25, 2023
Язык: Английский
Процитировано
41
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 83, С. 104432 - 104432
Опубликована: Апрель 6, 2023
Язык: Английский
Процитировано
30
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124986 - 124986
Опубликована: Май 24, 2023
Язык: Английский
Процитировано
29
Pharmaceutics, Год журнала: 2023, Номер 15(9), С. 2361 - 2361
Опубликована: Сен. 21, 2023
Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common method, although it not always effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One significant barriers that medications must overcome to exert a therapeutic effect impact first hepatic transit. Studies shown controlled-release systems using nanoparticles composed biodegradable natural polymers significantly improve administration, which why these materials attracted attention. Chitosan possesses wide variety properties functions pharmaceutical well healthcare industries. Drug encapsulation transport within body are two its important features. Moreover, chitosan can enhance efficacy by facilitating interaction target cells. Based on physicochemical properties, potentially be synthesized into nanoparticles, this review summarizes advances applications orally delivered nanoparticle interventions.
Язык: Английский
Процитировано
28
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 84, С. 104494 - 104494
Опубликована: Май 16, 2023
Язык: Английский
Процитировано
26
Cancer Pathogenesis and Therapy, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
10
International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100281 - 100281
Опубликована: Авг. 28, 2024
Cancer is the leading cause of death globally, and conventional treatments have limited efficacy with severe side effects. The use nanotechnology has potential to reduce effects drugs by creating efficient controlled anticancer drug delivery systems. Nanoparticles (NPs) used as carriers offer several advantages, including enhanced protection, biodistribution, selectivity and, pharmacokinetics. Therefore, this review devoted various organic (lipid, polymeric) well inorganic nanoparticles based on different building units providing a wide range potent Within these nanoparticulate systems, chitosan (CS)-based NPs are discussed particular emphasis due unique properties CS its derivatives non-toxicity, biodegradability, mucoadhesivity, tunable physico-chemical biological allowing their alteration specifically target cancer cells. In context streamlining systems (DDS), innovative nanoplatform-based therapy pathways involving passive active targeting stimuli-responsive DDS enhancing overall orthogonality developed NP-DDS towards included. most up-to-date information delivering anti-cancer using modern dosage forms specifically, CSNPs, summarised evaluated concerning benefits, limitations, advanced applications.
Язык: Английский
Процитировано
9
Cell Biochemistry and Function, Год журнала: 2024, Номер 42(4)
Опубликована: Май 28, 2024
Abstract Since most solid tumors have a low pH value, pH‐responsive drug delivery system may offer broad method for tumor‐targeting treatment. The present study is used to analyze the anticancer activity of carvacrol‐zinc oxide quantum dots (CVC‐ZnO QDs) against breast cancer cells (MDA‐MB‐231). CVC‐ZnO QDs demonstrate responsive and are specifically released within acidic tumor microenvironment. This property enables targeted exclusively while minimizing impact on normal cells. To synthesized ZnO QDs, CVC was loaded then examined by X‐ray diffraction, ultraviolet‐visible, Fourier transform infrared spectrophotometer, scanning electron microscopy‐energy dispersive X‐ray, transmission microscopy. For up 20 h, release in different pH‐buffered solutions. results showed that carvacrol stable an solution. Further, cytotoxicity assay, antioxidant, lipid peroxidation activity, reactive oxygen species, mitochondrial membrane potential, nuclear damage, ability cause apoptosis were all examined. Apoptosis markers such as Bcl2, Bax, caspase‐3, caspase‐9, also studied. In conclusion, destabilized MDA‐MB‐231cells under its microenvironment regulated apoptosis.
Язык: Английский
Процитировано
8