Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 57 - 211
Опубликована: Янв. 1, 2024
Язык: Английский
Deleted Journal, Год журнала: 2023, Номер 2(1), С. 288 - 306
Опубликована: Июль 26, 2023
Polysaccharides are inspiring and valuable molecules to the development of novel drug delivery systems owing their natural availability, non-toxicity, biocompatibility, good biological performance, chemical similarity physiological environment, besides noticeable use for tailored-materials assembly. Biodegradable hydrogels based on polysaccharides have been widely studied as potential pharmaceutical forms due controlled release properties, which improve bioavailability, therapeutic efficacy, patient compliance. Despite these advantages, polysaccharide materials present insufficient mechanical properties or processability, thus, overcome drawbacks, feasible suitable crosslinking methods employed strength stability. Therefore, this review presents recent advances in hydrogels, including chitosan, cellulose, hyaluronic acid, alginate, providing examples manufacturing processes with emphasis carriers delivery. Polysaccharide-based represent a sustainable, biocompatible, appreciable alternative obtain systems.
Язык: Английский
Процитировано
20
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135775 - 135775
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
9
Journal of Ocular Pharmacology and Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Posterior segment ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal vein occlusion, are leading causes of vision impairment blindness worldwide. Effective management these conditions remains a formidable challenge due to the unique anatomical physiological barriers eye, including blood-retinal barrier rapid drug clearance mechanisms. To address hurdles, nanostructured delivery systems proposed overcome barriers, target retina, enhance permeation while ensuring controlled release. Traditional therapeutic approaches, intravitreal injections, pose significant drawbacks, patient discomfort, poor compliance, potential complications. Therefore, understanding physiology mechanism eye could aid in design novel formulations that be noninvasive deliver drugs reach site is pivotal for effective treatment strategies. This review focuses on recent advances formulation strategies posterior delivery, highlighting their limitations. Furthermore, nanocarrier in-situ gel, niosomes, hydrogels, dendrimers, liposomes, nanoparticles, nanoemulsions more effectively selectively explored, supplemented with illustrative examples, figures, tables. aims provide insights into current state emphasizing need interdisciplinary approaches develop patient-centric, minimally invasive, solutions.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 135071 - 135071
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
5
Reactive and Functional Polymers, Год журнала: 2024, Номер 196, С. 105837 - 105837
Опубликована: Янв. 14, 2024
Язык: Английский
Процитировано
4
Biointerphases, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 1, 2025
The special structure of eyes and the existence various physiological barriers make ocular drug delivery one most difficult problems in pharmaceutical field. Considering patient compliance, local administration remains preferred method anterior part eyes. However, suffers from poor bioavailability, need for frequent administration, systemic toxicity. Administration posterior eye is more difficult, intravitreal injection often used. But faces compliance likely side effects after multiple injections. development nanocarrier technology provides an effective way to solve these problems. Among them, liposomes, as widely used carrier clinical application, have characteristics amphiphilic nanostructure, easy surface modification, extended release time, good biocompatibility, etc. liposomes are expected overcome obstacles effectively deliver drugs target site improve bioavailability. This review summarized controllable properties well application research progress diseases. In addition, we routes contained eyes, prospects treatment
Язык: Английский
Процитировано
0
Biomedical Materials, Год журнала: 2025, Номер 20(2), С. 025029 - 025029
Опубликована: Фев. 12, 2025
The combination of hydrogels with nanoformulations can significantly enhance the delivery and effectiveness drugs in ophthalmic drug systems. In current study, polyethylene glycol diacrylate (PEGDA)/thiolated gellan gum (GGSH) based on GGSH PEGDA were prepared via thiol-ene reaction using Irgacure 2959 as a photoinitiator. To this end, modification GG was achieved by esterification hydroxyl groups carboxyl group mercaptopropionic acid free thiol amount 95.5 μmol g-1. provide sustained release, chitosan nanoparticles (CSNPs) containing timolol maleate (TM) 56.4% entrapment efficiency synthesized desolvation method encapsulated developed hydrogel. values zeta potential particle size CSNPs +26.0 mV 182.4 nm, respectively. physico/chemical properties investigated texture analyzer, FT-IR, XRD, SEM. Thein vitrodegradation, swelling behavior, rheological assessments, cell viability testing, porosity determination evaluated. With increase concentration, mechanical increased. While rate swelling, degradation, release decreased. vitrobiocompatibility confirmed MTT test. According to anex vivostudy, ocular obtained transparent is promising due improved permeation TM CSNPs.
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123626 - 123626
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 107140 - 107140
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0
Nanomedicine, Год журнала: 2024, Номер 19(23), С. 1931 - 1951
Опубликована: Авг. 15, 2024
Despite the development of new generations antibiotics, vancomycin remained as a high-efficacy antibiotic for treating infections caused by MRSA. Researchers have explored various nanoformulations, aiming to enhance therapeutic efficacy vancomycin. Such novel formulations improve effectiveness drug cargoes in bacterial and minimizing risk adverse effects. The vast researches focuses on enhancing permeation ability through different biological barriers especially those gastrointestinal tract. Increasing loading tuning release from nanocarrier are other important goal many conducted studies. This study reviews newest nano-based key hospitalized infections.
Язык: Английский
Процитировано
2