bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 19, 2024
ABSTRACT
Background
The
development
of
nanocarriers
with
precise
control
over
drug
release
is
crucial
for
targeted
therapy.
This
study
focuses
on
the
design
and
optimization
pH-sensitive
gelatin/perfluorohexane
(PFH)
nanodroplets
loaded
berberine
chloride,
a
model
relevant
to
traditional
Chinese
medicine.
Subjects
Methods
Nanodroplets
were
prepared
using
an
emulsion
technique,
parameters
including
homogenization
rate,
polymer
concentration,
surfactant,
drug,
perfluorocarbon
conte
nt.
Results
optimized
formulation
resulted
in
mean
particle
size
281.7
nm
encapsulation
efficiency
66.8
±
1.7%.
Characterization
studies
confirmed
successful
pH-responsive
behavior.
Ultrasound
stimulation
significantly
enhanced
release,
150
kHz
frequency
proving
more
effective
than
1
MHz.
Stability
demonstrated
prolonged
stability
one
month
at
4°C.
Following
10
minutes
ultrasound
irradiation,
exhibited
89.4%
cumulative
release.
Conclusions
In
conclusion,
these
show
potential
delivering
chloride
controlled
manner,
connecting
medicine
contemporary
delivery
methods.
Nutrients,
Год журнала:
2023,
Номер
15(14), С. 3136 - 3136
Опубликована: Июль 13, 2023
Polyphenols
derived
from
fruits,
vegetables,
and
plants
are
bioactive
compounds
potentially
beneficial
to
human
health.
Notably,
such
as
quercetin,
curcumin,
epigallocatechin-3-gallate
(EGCG),
resveratrol
have
been
highlighted
antiproliferative
agents
for
cancer.
Due
their
low
solubility
limited
bioavailability,
some
alternative
nanotechnologies
applied
encapsulate
these
compounds,
aiming
improve
efficacy
against
In
this
comprehensive
review,
we
evaluate
the
main
nanotechnology
approaches
therapeutic
potential
of
polyphenols
cancer
using
in
vitro
studies
vivo
preclinical
models,
highlighting
recent
advancements
field.
It
was
found
that
polymeric
nanomaterials,
lipid-based
inorganic
carbon-based
nanomaterials
most
used
classes
nanocarriers
encapsulating
polyphenols.
These
delivery
systems
exhibit
enhanced
antitumor
activity
pro-apoptotic
effects,
particularly
breast,
lung,
prostate,
cervical,
colorectal
cells,
surpassing
performance
free
compounds.
Preclinical
trials
xenograft
animal
models
revealed
decreased
tumor
growth
after
treatment
with
polyphenol-loaded
systems.
Moreover,
interaction
polyphenol
co-delivery
polyphenol–drug
is
a
promising
approach
increase
anticancer
decrease
chemotherapy
side
effects.
innovative
hold
significant
implications
advancement
clinical
research.
Journal of Macromolecular Science Part A,
Год журнала:
2024,
Номер
61(5), С. 265 - 288
Опубликована: Март 19, 2024
Hydrogels
comprise
of
a
group
crosslinked
hydrophilic
polymeric
materials
which
are
capable
absorbing
and
holding
large
quantities
water
in
their
three-dimensional
network
structure
without
undergoing
dissolution.
More
importantly,
the
ability
'smart'
hydrogels
to
respond
certain
environmental
changes
e.g.
pH,
heat,
light,
magnetic
field,
biomolecules
have
set
them
apart
as
unique
class
materials.
A
combination
several
such
useful
properties
resulted
tremendous
progress
toward
development
advanced
hydrogel-based
materials,
is
evident
from
an
explosive
amount
research
publications
available
this
area
over
last
few
decades.
Owing
particularly
biocompatibility
biodegradability,
become
material
prime
importance
context
wide
range
applications
starting
simple
contact
lenses
more
complex
ones
tissue
repair,
drug
delivery,
sensors,
3D
bioprinting,
soft
robotics
agriculture.
This
review
includes
i)
overview
its
classifications
based
on
source,
structure,
crosslinking
mechanism
stimuli
responsiveness,
ii)
detailed
discussion
some
most
works
being
carried
out
field
years
smart
that
need
hour,
domain
biomedical
applications.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 8, 2024
Abstract
In
this
research,
using
a
microfluidic
chip,
nanocarrier
for
the
anticancer
drug
gefitinib
was
synthesized.
Chitosan
and
alginate
natural
polymers
were
utilized
synthesis
of
nanocarrier.
The
comprises
interaction
secondary
amine
functional
groups
molecules
with
carboxylate
polymer
to
form
primary
nucleus
followed
by
formation
through
self-assembly
chitosan
on
fabricated
chip.
chip
laser
engraving
poly(methyl
methacrylate)
sheets.
characterized
FT-IR,
DLS,
SEM,
TEM
techniques.
synthesized
had
size
distribution
5.30
±
2.60
nm
encapsulation
efficiency
percent
68.4%
in
optimum
conditions.
loading
calculated
as
50.2
mg
g
−1
Drug
release
studies
showed
that
is
sensitive
pH
releases
more
acidic
environments.
Cytotoxicity
studied
A549
non-small
cell
lung
cancer,
MTT
test
has
lower
IC
50
value
than
free
drug.
Also,
cytotoxicity
materials
used
do
not
show
significant
cytotoxicity.
Compared
previously
reported
method,
developed
microfluidic-assisted
method
advantages
such
faster
procedure
comparable
capacity.
This
review
provides
a
comprehensive
evaluation
of
the
anti-tumor
bioactivities
and
delivery
strategies
dietary
polyphenols,
as
well
their
application
in
development
nano-therapeutic
systems
for
tumor.
Macromolecular Chemistry and Physics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Abstract
Inspired
by
the
extreme
structural
complexity
and
functional
efficiency
of
biomolecules,
researchers
have
developed
stimuli‐responsive
materials,
capable
adapting
their
conformations
physicochemical
properties
upon
external
changes
in
temperature,
pH,
light,
etc.
These
materials
can
expand,
contract,
or
bend
response
to
stimuli,
which
makes
them
useful
for
a
variety
applications
such
as
biomedicine,
sensors,
shape‐memory
devices,
smart
interface
materials.
Multistimuli‐responsive
exhibit
enhanced
features
than
single‐/dual‐responsive
affording
fine
tuning
parameters.
Among
reversibly
cross‐linked
networks
generated
increasing
interest
recently
due
3D
architecture
unique
properties,
based
on
low
viscosity,
good
solubility,
high
functionality
building
blocks,
be
further
modified.
In
order
achieve
dynamic
self‐assembly,
future
research
macromolecular
self‐assembly
should
mimic
thec
structures,
functions,
processes
found
nature.
Abstract
Colorectal
cancer
(CRC)
is
the
third
most
common,
harmful,
and
universal
second
lethal
type.
This
paper
discusses
therapeutic
potential
of
curcumin,
a
significant
curcuminoid
found
in
substructure
plant
Curcuma
longa
(turmeric),
against
CRC.
Curcumin
has
ability
to
disrupt
variety
cellular
signaling
pathways
been
validated
several
preclinical
clinical
studies,
but
suffers
from
low
solubility
bioavailability.
Despite
widespread
use
curcumin
(CU)
colorectal
cancer,
it
presents
limitations,
such
as
Due
these
drawbacks,
researchers
focused
on
new
methods
carry
CU
into
cells
overcome
limits
treatments
with
CU.
One
leading
solutions
bioanalytical
methods,
which
are
based
using
combination
nanoparticles,
especially
magnetic
cause
targeted
transfer
drug
cells.
To
address
issues,
PLA-HA/Fe
3
O
4
nanoparticles
were
synthesized
loaded
curcumin.
The
average
size
zeta
properties
measured.
encapsulation
efficiency
cumulative
release
under
acidic
neutral
pH
(4.8,
6,
7.4)
values
evaluated,
well
cytotoxic
effect
HCT116
According
results
DLS
TEM
analysis,
PLA/Fe
/curcumin
had
spherical
structure
an
208
Å
±
12.8
nm
Zeta
−
18
(mV).
was
24.8
4.6
percent.
drug's
rate
influenced
by
levels.
After
14
days,
highest
98%
at
4.8
over
94%
6
(typical
cells).
In
contrast,
7.4
healthy
cells)
after
days
only
59%.
demonstrated
that
have
high
degree
biocompatibility
medications.
200
μg/ml
/Curcumin
58.63
3.7%
percent
cell
viability.
Ultimately,
PLA-HA,
Fe
,
Curcumin's
physicochemical
characteristics
impact
viability
render
them
valuable
instruments
for
precisely
delivering
drugs
–curcumin
well-targeted
delivery
system
upcoming
treatments,
evidenced
their
strong
effects
negligible
toxicity
towards
non-cancerous
Graphical
abstract
