Advanced Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 9, 2024
Abstract
Glucose‐derived
carbon
nanospheres
(CSP),
uniquely
derived
by
hydrothermal
condensation
process,
inherently
cross
blood–brain‐barrier
(BBB)
but
distribute
all
over
the
brain.
Albeit
its
potential
to
treat
glioma
as
an
effective
drug
delivery
system,
it
is
challenging
restrict
drug‐associated
CSP
within
region
and
reduce
non‐specific
side
effects.
Incidentally,
gliomas
moderately
express
sigma
receptors
(SR).
Earlier,
a
cationic
lipid‐conjugated
neuropsychotic
drug,
haloperidol
(H8)
developed
with
SR‐targetability
anticancer
effect
zero
BBB‐crossing
ability.
In
this
study,
surface
modified
H8
(CH8
nano‐conjugate)
dual
targeting
achieved
glioma‐tumor
microenvironment:
1)
cells
2)
pro‐proliferative
M2
tumor‐associated
macrophages
(TAM),
both
SR.
CH8‐treatment
increases
survivability
of
orthotopic
bearing
mice
significantly
reduces
tumor
burden
in
glioma‐subcutaneous
model.
Further
CH8‐surface
combining
brain
carmustine
(CH8‐CRM).
CH8‐CRM
nano‐conjugate
selectively
enhances
glioma‐carrying
aggressiveness
comparison
other
treatment
groups.
Lysates
from
CH8‐CRM‐treated
show
upregulation
cleaved‐caspase
3,
p53,
downregulation
pAkt.
The
combination
pronouncedly
anti‐glioma
H8.
Conclusively,
CH8‐mediated
dual‐targeting
via
SR
glioma‐associated
exemplifies
repurposing
drugs
for
treating
glioma.
Nano Biomedicine and Engineering,
Год журнала:
2024,
Номер
16(3), С. 498 - 509
Опубликована: Июль 2, 2024
The
aim
of
this
study
is
to
fabricate
a
multifunctional
biohybrid
composite
utilizing
double
walled
carbon
nanotubes
(DWCNTs)
as
carrier
for
loading
the
colistin
sulfate
(CLS)
through
application
sol-gel
technique.
resulting
was
analyzed
by
Fourier
transform
infrared
spectroscopy
(FTIR),
thermogravimetric
analysis
(TGA),
scanning
electron
microscope
(SEM),
X-ray
diffraction
patterns
(XRD),
and
particle
size
distribution
dynamic
light
scattering
technique
(DLS).
Furthermore,
an
assessment
in
vitro
bone
bioactivity
conducted
under
physiological
levels
Ca2+
PO4+
(SBF)
at
37
°C
pH
7.4
over
period
7
days.
Additionally,
cytotoxicity
against
mice
marrow
cells
evaluated
using
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide
(MTT)
assay.
outcomes
indicated
that
possessed
365
nm
in
diameter
with
PDI
0.21
(the
pure
CLS
untreated
DWCNTs
were
290
459
diameter,
respectively),
improved
biocompatibility,
promoted
formation
Ca-phosphate
apatite
layer
on
surface
Ca/P
ratio
approximately
1.78.
findings
collectively
validated
significant
contribution
peptide
DWCNTs-based
purposes
tissue
engineering.
E3S Web of Conferences,
Год журнала:
2024,
Номер
547, С. 03020 - 03020
Опубликована: Янв. 1, 2024
We
explore
the
many
ways
biocompatible
nanomaterials
may
be
used
in
sustainable
biomedical
settings.
Quantum
dots
are
10
nm
size,
carbon
nanotubes
50
nm,
iron
oxide
nanoparticles
25
gold
20
and
silver
30
nm.
The
physicochemical
features
of
these
different
from
one
another.
These
encapsulate
therapeutic
substances,
according
to
drug
loading
evaluations;
for
example,
can
hold
15
mg/g
oxide,
12
silver,
18
nanotubes,
carbon,
quantum
dots.
Nanoparticles
(95%
vitality
after
24
hours),
(93%
viability),
(97%
(92%
(90%
viability)
highlight
biocompatibility
materials.
Fluorescence
intensities
1000
AU
nanoparticles,
980
1050
900
1100
were
observed
vivo
imaging
investigations,
further
demonstrating
potential
as
contrast
agents.
By
conducting
thorough
assessments
analyses,
this
study
reveals
how
create
long-term
applications,
such
molecular
targeted
delivery,
which
will
improve
healthcare
solutions
patient
outcomes.
Nanomaterials
have
shown
significant
promise
for
enhancing
the
performance
of
composite
materials
and
increasing
their
functionality
various
industrial
applications.
This
review
explores
unique
properties
nanomaterials,
particularly
carbon-based
provides
key
findings
in
utilizing
them
to
enhance
performance.
It
highlights
specific
nano-based
potential
advancing
field
nanocomposites.
Challenges
associated
with
nanocomposite
production
utilization
are
also
discussed,
along
possible
solutions
address
them.
Finally,
study
recommendations
continued
research
innovation
nanocomposites
fully
unlock
benefits
these
advanced
broader
future
Advanced Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 9, 2024
Abstract
Glucose‐derived
carbon
nanospheres
(CSP),
uniquely
derived
by
hydrothermal
condensation
process,
inherently
cross
blood–brain‐barrier
(BBB)
but
distribute
all
over
the
brain.
Albeit
its
potential
to
treat
glioma
as
an
effective
drug
delivery
system,
it
is
challenging
restrict
drug‐associated
CSP
within
region
and
reduce
non‐specific
side
effects.
Incidentally,
gliomas
moderately
express
sigma
receptors
(SR).
Earlier,
a
cationic
lipid‐conjugated
neuropsychotic
drug,
haloperidol
(H8)
developed
with
SR‐targetability
anticancer
effect
zero
BBB‐crossing
ability.
In
this
study,
surface
modified
H8
(CH8
nano‐conjugate)
dual
targeting
achieved
glioma‐tumor
microenvironment:
1)
cells
2)
pro‐proliferative
M2
tumor‐associated
macrophages
(TAM),
both
SR.
CH8‐treatment
increases
survivability
of
orthotopic
bearing
mice
significantly
reduces
tumor
burden
in
glioma‐subcutaneous
model.
Further
CH8‐surface
combining
brain
carmustine
(CH8‐CRM).
CH8‐CRM
nano‐conjugate
selectively
enhances
glioma‐carrying
aggressiveness
comparison
other
treatment
groups.
Lysates
from
CH8‐CRM‐treated
show
upregulation
cleaved‐caspase
3,
p53,
downregulation
pAkt.
The
combination
pronouncedly
anti‐glioma
H8.
Conclusively,
CH8‐mediated
dual‐targeting
via
SR
glioma‐associated
exemplifies
repurposing
drugs
for
treating
glioma.
