Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2024,
Номер
3(5), С. 200 - 210
Опубликована: Ноя. 14, 2024
Transdermal
Drug
Delivery
Systems
(TDDS)
represent
a
significant
advancement
in
therapeutic
administration
by
allowing
drugs
to
bypass
the
gastrointestinal
system
and
first-pass
hepatic
metabolism,
enhancing
patient
compliance,
enabling
sustained
drug
release.
However,
traditional
TDDS
face
limitations,
including
resistance
from
skin's
natural
barrier
limited
efficacy
delivering
large
or
hydrophilic
molecules.
Microneedle
(MN)
technology
offers
breakthrough
solution,
using
minimally
invasive
micron-sized
needles
stratum
corneum,
facilitating
efficient
delivery
without
pain
discomfort.
This
review
explores
evolution
recent
advancements
microneedle
technology,
highlighting
its
role
overcoming
limitations
of
conventional
TDDS.
Microneedles
have
been
shown
enhance
bioavailability,
reduce
side
effects,
expand
range
deliverable
therapeutics,
vaccines,
insulin,
genetic
materials.
The
development
bioinspired
4D
microneedles
further
extends
their
application
diagnostics
cosmetic
treatments,
positioning
MNs
as
versatile
tool
modern
medicine.
Key
sections
focus
on
types
microneedles—solid,
coated,
dissolving,
hollow,
hydrogel-forming—and
respective
fabrication
methods,
materials,
mechanisms.
also
discusses
challenges
related
scaling
up
production,
ensuring
consistent
quality,
regulatory
hurdles
achieving
clinical
approval.
Future
directions
include
integration
with
nanotechnology,
combination
therapies,
sustainable
design,
particularly
developing
regions
where
biodegradable
materials
may
address
environmental
disposal
concerns.
potential
for
revolutionize
transdermal
delivery,
diagnostics,
monitoring
is
significant,
ongoing
research
paving
way
multifunctional
applications
that
can
reshape
care
treatment
modalities.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(7), С. 4254 - 4269
Опубликована: Июнь 12, 2024
The
skin,
being
the
largest
organ
of
human
body,
is
susceptible
to
damage
resulting
in
wounds
that
are
vulnerable
pathogenic
attacks
and
fail
provide
effective
protection
for
internal
tissues.
Therefore,
it
crucial
expedite
wound
healing.
In
recent
years,
microneedles
have
garnered
significant
attention
as
an
innovative
drug
delivery
system
owing
their
noninvasive
painless
administration,
simplified
application
process,
precise
control
over
release,
versatile
loading
capabilities.
Consequently,
they
hold
immense
potential
treatment
skin
wound.
This
review
presents
a
comprehensive
design
strategy
microneedle
promoting
First,
process
healing
characteristics
specific
elucidated.
strategies
subsequently
presented
classified
based
on
structural
therapeutic
methodologies.
Finally,
succinct
recapitulation
previously
discussed
points
prospective
analysis
provided.
Pharmaceutical Development and Technology,
Год журнала:
2023,
Номер
28(10), С. 1016 - 1031
Опубликована: Ноя. 21, 2023
Proteins
and
peptides
are
rapidly
developing
pharmaceutical
products
expected
to
continue
growing
in
the
future.
However,
due
their
nature,
delivery
is
often
limited
injection,
with
drawbacks
such
as
pain
needle
waste.
To
overcome
these
limitations,
microneedles
technology
developed
deliver
protein
peptide
drugs
through
skin.
One
type
of
microneedles,
known
dissolving
has
been
extensively
studied
for
delivering
various
proteins
peptides,
including
ovalbumin,
insulin,
bovine
serum
albumin,
polymyxin
B,
vancomycin,
bevacizumab.
This
article
discusses
polymer
materials
used
fabricating
which
poly(vinylpyrrolidone),
hyaluronic
acid,
poly(vinyl
alcohol),
carboxymethylcellulose,
GantrezTM,
well
other
biopolymers
like
pullulan
ulvan.
The
paper
focused
solely
on
solvent
casting
micromoulding
method
containing
will
be
divided
into
one-step
two-step
micromoulding.
Additionally,
future
considerations
market
plan
discussed
this
article.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 11, 2024
Obesity,
characterized
by
excessive
storage
of
lipids,
has
become
a
global
pandemic
with
high
incidence
levels,
and
its
forecast
is
not
encouraging.
Currently,
there
are
different
strategies
to
treat
obesity;
however,
these
conventional
methods
have
various
limitations.
Lifestyle
changes
may
result
in
poor
outcomes
due
the
complexity
obesity
causes,
pharmaceutic
treatments
produce
severe
side
effects,
bariatric
surgery
highly
invasive.
In
search
for
alternative
fight
obesity,
transdermal
drug
delivery
systems
anti-obesogenic
molecules
gained
particular
attention.
However,
diffusion
through
skin
main
drawback
characteristics
layers
skin,
principally
ACS Materials Au,
Год журнала:
2024,
Номер
5(1), С. 115 - 140
Опубликована: Ноя. 28, 2024
The
delivery
of
molecules,
such
as
DNA,
RNA,
peptides,
and
certain
hydrophilic
drugs,
across
the
epidermal
barrier
poses
a
significant
obstacle.
Microneedle
technology
has
emerged
prominent
area
focus
in
biomedical
research
because
its
ability
to
deliver
wide
range
biomolecules,
vaccines,
medicines,
other
substances
through
skin.
Microneedles
(MNs)
form
microchannels
by
disrupting
skin's
structure,
which
compromises
function,
facilitating
easy
penetration
drugs
into
These
devices
enhance
administration
many
therapeutic
skin,
enhancing
their
stability.
Transcutaneous
medications
using
microneedle
patch
offers
advantages
over
conventional
drug
methods.
containing
active
can
be
stimulated
different
internal
external
factors
result
regulated
release
substances.
To
achieve
efficient
desired
location,
it
is
necessary
consider
design
needles
with
appropriate
optimized
characteristics.
choice
materials
for
developing
manufacturing
these
vital
determining
pharmacodynamics
pharmacokinetics
delivery.
This
article
provides
most
recent
update
overview
numerous
systems
that
utilize
activators
stimulate
components
from
microneedles.
Further,
discusses
utilized
producing
microneedles
strategies
important
managing
drugs.
An
explanation
commonly
employed
fabrication
techniques
applications
electronics,
particularly
integrated
systems,
discussed.
successfully
implement
clinical
settings,
essential
comprehensively
assess
several
factors,
biocompatibility,
stability,
safety,
production
cost.
Finally,
an
in-depth
review
criteria
difficulties
potential
future
direction
delivering
monitoring
diseases
explored.
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Recent
developments
in
polymer
materials
have
led
to
an
increased
implementation
of
hydrogels
biomedical
settings,
especially
the
creation
smart
hydrogels.
Traditional
single‐network
often
exhibit
challenges,
such
as
poor
mechanical
strength,
insufficient
biocompatibility,
and
slow
response
rates.
To
address
these
issues,
researchers
introduced
Interpenetrating
Polymer
Network
(IPN)
hydrogels,
which
significantly
improve
strength
via
topological
entanglements
physical
interactions.
This
dual‐network
design
not
only
enhances
biocompatibility
but
also
responsiveness
stimuli,
endowing
with
distinctive
properties
like
cell
adhesion,
conductivity,
hemostatic
functions,
antioxidant
abilities,
color‐changing
properties.
The
purpose
this
article
is
elucidate
factors
that
trigger
stimuli
IPN
their
impacts
on
cellular
behavior,
various
applications
they
can
serve.
A
comprehensive
overview
provided
regarding
classification,
mechanisms,
performance
attributes,
related
subjects.
Ultimately,
review
emphasizes
promise
hold
fulfilling
increasing
need
for
innovative
improved
features
sector.
Journal of Biomedical Materials Research Part A,
Год журнала:
2025,
Номер
113(4)
Опубликована: Март 28, 2025
ABSTRACT
Microneedles
have
emerged
as
an
effective
strategy
to
bypass
the
stratum
corneum
by
creating
microchannels
in
skin,
allowing
for
enhanced
drug
permeation
with
minimal
invasiveness.
Pectin,
a
natural
polysaccharide,
when
modified
thiol
(‐SH)
groups,
exhibits
redox‐sensitive
behavior,
making
it
responsive
reducing
agents
such
glutathione
and
dithiothreitol
(DTT).
The
objective
of
this
study
was
investigate
transdermal
delivery
efficacy
redox‐responsive
microneedle‐containing
thiolated
pectin.
Various
molar
ratios
pectin
were
synthesized
through
ring‐opening
reaction
followed
nucleophilic
substitution
propylene
sulfide
MN
matrices
formulated
at
various
ratios,
hyaluronic
acid,
collagen,
trehalose.
stiffness
mechanical
strength
microneedles
increased
higher
thiol‐containing
molecules.
vitro
skin
release
showed
large
amount
FITC
no
group
conjugated
MN‐thio:
(20:10)
H
2
O
greater
DTT
concentrations,
absence
DTT,
50
times
less
than
without
thiol.
In
summary,
microneedle
containing
may
be
promising
vehicle
harvesting
human
body.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Obesity
is
a
global
metabolic
health
epidemic
characterized
by
excessive
lipid
and
fat
accumulation,
leading
to
severe
conditions
such
as
diabetes,
cancer,
cardiovascular
disease.
Immediate
attention
management
of
obesity-related
risks
are
most
warranted.
The
imbalance
between
absorption,
rate,
environmental
genetic
factors
responsible
for
obesity.
Treatment
typically
involves
lifestyle
modifications,
pharmacotherapy,
surgery.
While
changes
crucial,
effective
treatment
often
necessitates
medication
preferred
adjunct
strategy.
However,
medications
commonly
used,
oral
show
side
effects
due
systemic
exposure
and,
thus,
may
not
effectively
target
the
intended
areas,
drug
loss.
On
other
hand,
transdermal
administration
drugs
with
microneedle
(MN)-based
technologies,
painless
delivery
approach
patient
compliance,
gaining
interest
an
alternative
obesity
treatment,
it
directly
targets
adipose
tissue
via
local
delivery,
minimizing
system
dose
reduction.
This
Review
addresses
pathophysiology
obesity,
current
strategies,
challenges
in
using
conventional
formulations,
importance
use
nano-based
through
MNs
promising
platform
nanoparticle-based
anti-obesity
medications.
potential
combining
stimuli-responsive
non-responsive
adjuvant
therapies
enhance
efficacy
outcomes
explored.
In
addition,
limitations
future
perspectives
related
addressed
highlight
transformative
this
technology
management.
hold
promise
precisely
delivering
while
requiring
lower
dosages
compared
or
injectable
ultimately
improving
quality
life
individuals
struggling
its
associated
comorbidities.
