Immunomodulation in Bone Tissue Engineering: Recent Advancements in Scaffold Design and Biological Modifications for Enhanced Regeneration

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Bone defects, whether caused by trauma, cancer, infectious diseases, or surgery, can significantly impair people's quality of life. Although autografts are the gold standard for treating bone they often fall short in adequately forming tissue. The field tissue engineering has made strides using scaffolds with various biomaterials, stem cells, and growth factors to enhance healing. However, some biological structures do not yield satisfactory therapeutic outcomes new formation. Recent studies have shed light on crucial role immunomodulation, specifically interaction between implanted scaffold host immune systems, regeneration. Immune particularly macrophages, pivotal inflammatory response, angiogenesis, osteogenesis. This review delves into system's mechanism toward foreign bodies recent advancements scaffolds' physical properties that foster regeneration modulating macrophage polarization an anti-inflammatory phenotype enhancing osteoimmune microenvironment.

Язык: Английский

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From silent partners to potential therapeutic targets: macrophages in colorectal cancer

Cancer Immunology Immunotherapy, Год журнала: 2025, Номер 74(4)

Опубликована: Фев. 25, 2025

Cancer cells grow and survive in the tumor microenvironment, which is a complicated process. As key part of how colorectal cancer (CRC) progresses, tumor-associated macrophages (TAMs) exhibit double role. Through angiogenesis, this TAM can promote growth cancers. Although being able to modify adjust immune great advantage, these also anti-cancer properties including direct killing cells, presenting antigens, aiding T cell-mediated responses. The delicate regulatory mechanisms between system tumors are composed complex network pathways regulated by several factors hypoxia, metabolic reprogramming, cytokine/chemokine signaling, cell interactions. Decoding figuring out systems become significant building targeted treatment programs. Targeting TAMs CRC involves disrupting chemokine signaling or adhesion molecules, reprogramming them an anti-tumor phenotype using TLR agonists, CD40 modulation, selectively removing subsets that growth. Multi-drug resistance, absence accurate biomarker, drug non-specificity major problems. Combining macrophage-targeted therapies with chemotherapy immunotherapy may revolutionize treatment. Macrophage studies will advance new technology multi-omics methodologies help us understand build specific efficient treatments.

Язык: Английский

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In silico and in vitro profiling of sphingomyelin loaded zein nanoconstructs with optimized aromatic interactions and pharmacokinetics for colon cancer therapeutics

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141845 - 141845

Опубликована: Март 1, 2025

Язык: Английский

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Probing the Structural Elements of Polysaccharide Adjuvants for Enhancing Respiratory Mucosal Response: From Surmounting Multi-Obstacles to Eliciting Cascade Immunity

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

The immunomodulatory effects and excellent tolerability of polysaccharides make them optimal candidates for pulmonary vaccine adjuvants. Yet, the structure-immunostimulatory activity relationship remains unrevealed. Here, we developed nanovaccines decorated with four distinct structures─hyaluronic acid (HA), pectin (PC), chondroitin sulfate (SC), heparan (SH)─all sharing similar particle sizes zeta potential. Polysaccharides containing groups (SC, SH) exhibited superior efficacy in overcoming natural inhalation barriers recruiting dendritic cells (DC). DC stimulation assays revealed that HA SH significantly upregulated expression costimulation signals, IL-6 secretion rising over 8.7-fold compared to pure OVA. Fluorescence resonance energy transfer demonstrated their detachment within lysosomal microenvironment, thereby enhancing antigen cross-presentation. However, vivo findings only showed CCR7 chemokine swiftly migrated lymph nodes. Molecular docking Western blot analyses further elucidated involvement TLR─MyD88─TRAF6─NF-κB/MAPK/IRF-7 signaling pathways. Notably, SH-modified induced a more robust cellular humoral immune response potential memory. This study confirms enhance activation combining acetyl offers promising adjuvant configuration augmenting mucosal, cellular, immunity.

Язык: Английский

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Exploiting the immune system in hepatic tumor targeting: Unleashing the potential of drugs, natural products, and nanoparticles

Pathology - Research and Practice, Год журнала: 2024, Номер 256, С. 155266 - 155266

Опубликована: Март 19, 2024

Язык: Английский

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Nanotechnology and Cancer Therapy Strategies

Interdisciplinary cancer research, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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Biomaterials and Nanomedicines: Progress in Cancer Research

Interdisciplinary cancer research, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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Biomimetic etoposide-loaded PLGA nanoparticles induce immunogenic cell death against colorectal cancer

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106349 - 106349

Опубликована: Окт. 1, 2024

Язык: Английский

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