Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Plants, Год журнала: 2024, Номер 13(6), С. 913 - 913

Опубликована: Март 21, 2024

The paper provides a comprehensive examination of heavy metal stress on medicinal plants, focusing its impact antioxidant capacity and biosynthetic pathways critical to their therapeutic potential. It explores the complex relationship between metals physiological biochemical responses highlighting how disrupts pathways, altering concentrations secondary metabolites. This disruption may compromise overall quality efficacy requiring holistic understanding cumulative impacts. Furthermore, study discusses potential targeted genetic editing enhance plant resilience against by manipulating genes associated with defenses. approach represents promising frontier in safeguarding plants metal-contaminated environments. Additionally, research investigates role phytohormone signaling adaptive mechanisms stress, revealing influence responses, thereby adding complexity adaptation. underscores importance innovative technologies global cooperation protecting plants’ highlights need for mitigation strategies address contamination effectively.

Язык: Английский

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Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2108 - 2108

Опубликована: Фев. 9, 2024

Betulinic acid is a naturally occurring compound that can be obtained through methanolic or ethanolic extraction from plant sources, as well chemical synthesis microbial biotransformation. has been investigated for its potential therapeutic properties, and exhibits anti-inflammatory, antiviral, antimalarial, antioxidant activities. Notably, ability to cross the blood-brain barrier addresses significant challenge in treating neurological pathologies. This review aims compile information about impact of betulinic an antitumor agent, particularly context glioblastoma. Importantly, demonstrates selective activity against glioblastoma cells by inhibiting proliferation inducing apoptosis, consistent with observations other cancer types. Compelling evidence published highlights acid's action suppressing Akt/NFκB-p65 signaling cascade enhancing cytotoxic effects chemotherapeutic agent temozolomide. Interesting findings also suggest focus on researching reduction glioblastoma's invasiveness aggressiveness profile. involves modulation extracellular matrix components, remodeling cytoskeleton, secretion proteolytic proteins. Drawing comprehensive review, we conclude formulations nanoparticles and/or ionic liquids are promising drug delivery approaches translation into clinical applications treatment management

Язык: Английский

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Flavonoids and Flavonoid-Based Nanopharmaceuticals as Promising Therapeutic Strategies for Colorectal Cancer—An Updated Literature Review

Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 231 - 231

Опубликована: Фев. 8, 2025

Colorectal cancer (CRC) represents one of the most serious health issues and third commonly diagnosed worldwide. However, treatment options for CRC are associated with adverse reactions, in some cases, resistance can develop. Flavonoids have emerged as promising alternatives prevention therapy due to their multitude biological properties ability target distinct processes involved pathogenesis. Their innate disadvantageous (e.g., low solubility stability, reduced bioavailability, lack tumor specificity) delayed potential inclusion flavonoids regimens but hastened design nanopharmaceuticals comprising a flavonoid agent entrapped nanosized delivery platform that not only counteract these inconveniences also provide an augmented therapeutic effect elevated safety profile by conferring targeted action. Starting brief presentation pathological features overview classes, present study comprehensively reviews anti-CRC activity different from mechanistic perspective while portraying latest discoveries made area flavonoid-containing nanocarriers proved efficient management. This review concludes showcasing future perspectives advancement flavonoid-based research.

Язык: Английский

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Targeting EGFR and PI3K/mTOR pathways in glioblastoma: innovative therapeutic approaches

Medical Oncology, Год журнала: 2025, Номер 42(4)

Опубликована: Март 10, 2025

Язык: Английский

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Multifunctional carbonized polymer dots: Synthesis and applications in retarding protein amyloid aggregation, capturing free radicals and cell imaging

Journal of Molecular Structure, Год журнала: 2024, Номер 1319, С. 139419 - 139419

Опубликована: Июль 26, 2024

Язык: Английский

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