Pharmacon Jurnal Farmasi Indonesia,
Год журнала:
2024,
Номер
unknown, С. 161 - 175
Опубликована: Дек. 31, 2024
Antibiotic-loaded
nanofiber-based
drug
delivery
systems
represent
a
novel
approach
to
treating
complex
bone
infections,
particularly
osteomyelitis
caused
by
antibiotic-resistant
bacteria
such
as
Methicillin-resistant
Staphylococcus
aureus
(MRSA).
These
offer
localized,
sustained
release,
significantly
reducing
systemic
side
effects
and
mitigating
the
development
of
antibiotic
resistance.
This
review
evaluates
advancements
in
electrospun
nanofibers
with
biodegradable
polymers
like
Poly(lactic-co-glycolic
acid)
(PLGA)
Polycaprolactone
(PCL),
which
ensure
controlled
release
while
supporting
regeneration.
A
systematic
search
using
PRISMA
guidelines
across
ScienceDirect
ACS
Publication
databases
(2020-2024)
identified
42
relevant
studies.
The
inclusion
bioactive
agents
hydroxyapatite
was
found
enhance
antibacterial
properties
accelerate
tissue
demonstrates
that
antibiotic-loaded
promising,
targeted
therapeutic
alternative
conventional
treatments,
for
similar
challenging
infections.
Future
research
directions
will
focus
on
optimizing
nanofiber
compositions
functionalities
better
meet
clinical
needs,
ensuring
more
efficient
personalized
management
severe
Nanofibers
and
nanocomposites
have
emerged
as
critical
materials
in
biomedical
applications,
particularly
for
tissue
engineering
medication
delivery.
These
sophisticated
nanomaterials
are
at
the
forefront
of
study
because
their
distinct
features,
which
improve
biocompatibility,
mechanical
strength,
functional
adaptability.
This
review
examines
most
recent
advances
nanomaterial
production,
characteristics,
demonstrating
transformational
promise
medicinal
treatments
procedures.
The
advancement
advanced
production
processes
such
electrospinning,
self-assembly,
situ,
polymerization
has
substantially
improved
structural
properties
nanofibers
nanocomposites.
techniques
resulted
with
a
high
surface
area-to-volume
ratio,
customizable
degradation
rates,
capacity
to
closely
imitate
extracellular
matrix,
making
them
great
candidates
scaffolding
controlled
drug
delivery
systems.
flexibility
these
applications
is
also
notable
it
offers
new
avenues
concentrated
sustained
administration,
treating
variety
medical
problems.
Furthermore,
demonstrated
tremendous
potential
regenerative
medicine,
providing
novel
solutions
formation
bone,
cartilage,
skin,
neural
tissues.
create
tissues
that
resemble
natural
shapes
functions
holds
enormous
solving
repair
regeneration
difficulties.
As
improvements
continue,
incorporation
nanotechnology
into
projected
transform
healthcare
by
more
effective,
targeted,
personalized
treatments.
advancements
mark
step
forward,
revolutionary
power
future
medicine.
continuing
investigation
development
anticipated
result
innovative
medicines
patient
outcomes
advance
profession
engineering.
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Electrospun
fish
gelatin
(FGel)
nanofibers
(NF)
mimic
the
natural
bodies
extracellular
matrix's
(ECM)
structure
and
are
an
attractive
material
for
many
biomedical
applications.
However,
FGel
poor
mechanical
properties
rapid
dissolution
in
aqueous
media
paired
with
usually
low
productivity
of
typical
electrospinning
process
necessitate
further
effort
overcoming
these
issues.
In
this
study,
alternating
field
(AFES)
fabricates
cold
water
skin
nanofibrous
materials
(FGel
NFM)
up
to
10
wt.%
Dextran
(DEX)
or
acetyl
glucosamine
(AGA)
from
pure
solutions
at
7.92-8.90
g∙h-1.
Thermal
crosslinking
as-spun
resulted
FGel-based
NFM
125-325
nm
fiber
diameters.
DEX
(MW500k
MW75k)
AGA
additives
cause
different
effects
on
diameters,
structure,
tensile
degradation
behavior,
vitro
performance.
All
tested
reveal
favorable,
but
not
same,
cellular
response
through
formation
a
confluent
layer
surface
regardless
fibers'
composition
despite
significant
difference
properties.
Results
show
that
AFES
thermal
can
lead
sustainable
"green"
fabrication
technology
mono-
polysaccharide
modified
scaffolds
parameters
attuned
targeted
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
ABSTRACT
Recently,
there
has
been
a
surge
in
scholarly
interest
regarding
the
application
of
sophisticated
materials
technology
to
expedite
wound
healing,
particularly
through
integration
nanocomposites
endowed
with
multifaceted
functionalities
augment
efficacy
care
products.
In
order
propose
an
external
power‐free
healing
dressing
electrical
stimulation
function,
polyvinylidene
fluoride
(PVDF)
nanofibers
incorporating
graphene
oxide
(GO)
at
varying
concentrations
were
fabricated
via
electrospinning
technique.
Scanning
electron
microscopy
(SEM)
was
employed
reveal
morphology
composite
nanofibers.
Fourier
transform
infrared
(FTIR)
spectroscopy
and
X‐ray
diffraction
(XRD)
analyses
confirmed
transition
PVDF
from
α
phase
β
phase.
The
antibacterial
PVDF/GO
against
Staphylococcus
aureus
rigorously
examined.
Results
indicated
marked
enhancement
correlation
increasing
content
GO.
Moreover,
piezoelectric
property
assessments,
cytotoxicity,
hemolysis
tests
meticulously
performed.
outcomes
suggested
that
containing
0.5
w/w%
GO
(PVDF/GO‐0.5)
demonstrated
superior
performance
across
all
evaluated
metrics,
terms
mechanical
properties,
characteristics,
efficacy.
These
findings
imply
PVDF/GO‐0.5
possess
capability
mimic
endogenous
electric
field,
which
is
beneficial
boost
cellular
migration
proliferation,
thereby
accelerating
process.
Overall,
innovative
proposed
this
study
can
be
considered
highly
promising
candidate
field
tissue
engineering.
Royal Society of Chemistry eBooks,
Год журнала:
2024,
Номер
unknown, С. 214 - 250
Опубликована: Ноя. 15, 2024
The
development
of
biocompatible
nanofibres
through
electrospinning
is
a
promising
method
for
engineers
in
the
biomedical
field.
existing
coating
technologies
medical
field
have
various
limitations,
and
more
investigations
are
needed
to
improve
their
biocompatibility,
controlled
release
properties,
mechanical
strength.
Designing
new
materials
that
can
interact
efficiently
with
biological
systems
offer
numerous
functional
advantages
major
challenge
device
manufacturing
tissue
engineering.
This
chapter
reviews
approaches
used
create
nanofibres,
including
design,
fabrication
functionalization.
applications
these
coatings
also
reviewed.
Furthermore,
we
discuss
methods,
used,
key
parameters
impact
fibre
morphology
physiochemical
properties.
Moreover,
incorporation
bioactive
elements
drugs
into
therapeutic
explored.
biologically
friendly
be
an
effective
approach
improving
coatings.
Such
enhance
properties
such
as
drug
delivery,
regeneration,
implant
integration,
offering
enormous
potential
patient
welfare.
Future
research
areas
include
investigating
use
advanced
procedures
enhanced
control
over
nanofibre
composition
design
fabrication.
