Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 12889 - 12937

Опубликована: Дек. 1, 2024

Abstract: Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, drug/gene delivery. Among these, zinc (ZnO) NPs stand out versatility effectiveness. Recently, ZnO become a primary material various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, automotive industries. can generate reactive oxygen species induce cellular apoptosis, thus underpinning potent anticancer antibacterial properties. To meet growing demand, numerous synthetic approaches been developed produce NPs. However, traditional manufacturing processes often involve economic environmental costs, prompting search more sustainable alternatives. Intriguingly, synthesis methods utilizing plants, plant extracts, or microorganisms emerged ideal producing These green production techniques offer medicinal, economic, environmental, health benefits. This review highlights latest advancements applications, showcasing potential revolutionize field with eco-friendly cost-effective solutions. Keywords: antimicrobial, antioxidant, synthesis, nanomedicine, nanoparticle,

Язык: Английский

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Natural Biogenic Templates for Nanomaterial Synthesis: Advances, Applications, and Environmental Perspectives

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

This review explores the use of biogenic templates in nanomaterial synthesis, emphasizing their role promoting environmentally sustainable nanotechnology. It categorizes various templates, including agricultural byproducts and microorganisms, stating suitability for forming nanostructures due to distinct properties. A comparative analysis monostep multistep synthesis methods is provided, focusing on efficiencies outcomes when using templates. Further, this also highlights how these can generate complex hybrid materials with enhanced functionalities. Applications across biomedicine, biotechnology, environmental science, energy are discussed along utilization scope agriculture electronics. Benefits from biotemplates include sustainability, low cost, reduced toxicity, but challenges like scalability, reproducibility, regulatory compliance persist. Future research focuses improving techniques, discovering new evaluating cytotoxic impacts, especially biomedical uses. In conclusion, reaffirms potential while highlighting ongoing that need be addressed broader adoption.

Язык: Английский

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Green synthesis of nano zero-valent iron doped on bimetallic Ti/Mo-MOF for highly sensitive Peroxidase like colorimetric detection of Cholesterol and antioxidant/antimicrobial efficiencies

Physica Scripta, Год журнала: 2024, Номер 99(7), С. 075985 - 075985

Опубликована: Июнь 12, 2024

Abstract In this research paper, we report a clean and simple approach for the phytosynthesis of nanoparticles zero-valent iron (nZVI) through in situ reduction Fe 2+ to 0 using red cabbage extract. These nZVI were then loaded onto Ti/Mo-MOF nanostructure, resulting formation novel nZVI@Ti/Mo-MOF nanocomposite. To synthesize iron, utilized extract as reducing agent. Subsequently, synthesized incorporated into create The characterization biosynthesized nanocomposite was conducted UV–vis spectroscopy, FT-IR, XRD, XPS, FESEM, EDS. used sensitive peroxidase colorimetric sensing cholesterol. Under optimal conditions, cholesterol concentration range investigated from 1.0 nM 100.0 nM, which that show linear relationship with detection response. limit sensor is 6.24 nM. Furthermore, antioxidant properties antimicrobial activity its constituents against four bacterial strains well two fungal strains. Additionally, demonstrated superior compared other compounds paves way manufacturing innovation.

Язык: Английский

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Zero‐Waste Production of Copper Nanoparticles and Activated Carbon from Erigeron canadensis L.: A Sustainable Approach for Environmental and Health Applications

ChemistrySelect, Год журнала: 2025, Номер 10(7)

Опубликована: Фев. 1, 2025

Abstract This study presents a novel, zero‐waste process for producing copper nanoparticles (CuNPs), activated carbons (ACs), and oil extract (OE) from plant Erigeron canadensis L. in Sp. Pl.: 863 (1753). method optimizes resource utilization eliminates waste, offering sustainable approach to green synthesis. The NPs were characterized using XRD, SEM, FTIR. Their effectiveness was evaluated through comparative studies on methylene blue removal, antioxidant capacity, antibacterial activity. prepared OE exhibited superior properties, particularly against Klebsiella pneumoniae subsp . ATCC 13883 (inhibition zone: 19 ± 0 mm) Proteus vulgaris RSKK 96029 18.7 0.6 mm). AC demonstrated exceptional dye adsorption efficiency, ranging 98.62% 99.50%. Antioxidant tests revealed that CuNPs possessed strong with an IC 50 of 0.023 0.002 mg/mL the DPPH radical scavenging test 0.41 0.07 iron chelation test. lower capacity (0.43 0.01) but significant iron‐chelating ability (41.94 1.06). In comparison, standard antioxidants EDTA BHT showed their respective tests. These experimental findings underscore potential this bio zero‐waste‐derived products environmental biomedical applications, highlighting its broad applicability.

Язык: Английский

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Innovative Approaches to Combating Dental Biofilms: Nanotechnology and its Applications

Biocatalysis and Agricultural Biotechnology, Год журнала: 2024, Номер 61, С. 103406 - 103406

Опубликована: Окт. 1, 2024

Язык: Английский

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Comparative Study of Phytochemical Analysis and Anti-Microbial Activity of <em>Ziziphus spina-christi</em> L. Leaves Extracts From Different Areas in Sudan

Опубликована: Июнь 7, 2024

We conducted a study exploring the potential of medicinal plant Ziziphus spina-christi as source antimicrobial compounds. With growing threat antibiotic resistance, we were particularly interested in evaluating plant-derived natural products for their ability to fight infections. collected Z. leaves from four different regions Sudan and extracted them with ethanol. Our phytochemical screening revealed presence several secondary metabolites, including flavonoids, triterpenes, sterols, tannins, saponins, cardiac glycosides, reducing sugars. Alkaloids anthraquinones not detected. then tested ethanolic extracts activity against range bacterial fungal pathogens using agar well diffusion method. Interestingly, observed significant differences between locations. The extract Khartoum city exhibited highest potency, followed by Al-Rahad, Al-Hidiba, finally Al Damazin. Based on these findings, concluded that contain diverse array phytochemicals applications. variation effects may be attributed environmental factors influencing plant's chemical composition. Further research is warranted identify specific bioactive compounds responsible activities. This could pave way development plant-based agents combat drug-resistant alleviate global public health crisis posed rise resistance.

Язык: Английский

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Biosynthesized silver nanoparticles mediated by Ammi visnaga extract enhanced systemic resistance and triggered multiple defense-related genes, including SbWRKY transcription factors, against tobacco mosaic virus infection

BMC Plant Biology, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 7, 2024

Abstract Background Tobacco mosaic virus (TMV) is a highly infectious plant that affects wide variety of plants and reduces crop yields around the world. Here, we assessed effectiveness using Ammi visnaga aqueous seed extract to synthesize silver nanoparticles (Ag-NPs) their potential combat TMV. Different techniques were used characterize Ag-NPs, such as scanning transmission electron microscopy (SEM, TEM), energy-dispersive X-ray spectroscopy (EDS), fourier transform infrared (FTIR), dynamic light scattering (DLS). Results TEM demonstrated synthesized Ag-NPs had spherical form with an average size 23–30 nm zeta value -15.9 mV, while FTIR revealed various functional groups involved in Ag-NP stability capping. Interestingly, Pre-treatment tobacco (protective treatment) at 100–500 µg/mL significantly suppressed viral symptoms, Post-treatment (curative delayed appearance. Furthermore, protective curative treatments increased chlorophyll b, total flavonoids, soluble carbohydrates, antioxidant enzymes activity (PPO, POX CAT). Simultaneously, application resulted decrease levels oxidative stress markers (H 2 O MDA). The RT-qPCR results volcano plot analysis showed trigger regulate transcription ten defense-related genes ( SbWRKY-1 , SbWRKY-2 JERF-3 GST-1 POD PR-1 PR-2 PR-12 PAL-1 HQT-1 ). heatmap primary gene anthocyanidin production, was consistently most expressed across all throughout study. Analysis co-expression network 9 central among studied genes, followed by . Conclusions Overall, reported antiviral properties and/or curative) biosynthesized against TMV lead us recommend simple, stable, eco-friendly agent developing pest management programs infections.

Язык: Английский

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Metal nanoparticles and their toxicity impacts on microorganisms

Biologia, Год журнала: 2024, Номер 79(9), С. 2843 - 2862

Опубликована: Июль 31, 2024

Язык: Английский

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Therapeutic approaches of nanostructure metallic materials in management of colorectal cancer: Recent advancement

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106338 - 106338

Опубликована: Окт. 1, 2024

Язык: Английский

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Biosynthesized silver nanoparticles mediated by Ammi visnaga extract enhanced systemic resistance and triggered multiple defense-related genes, including SbWRKY transcription factors, against tobacco mosaic virus infection

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 27, 2024

Background Tobacco mosaic virus (TMV) is a highly infectious plant that impacts broad variety of plants and reduces crop yield around the world. Here, we assessed effectiveness using Ammi visnaga aqueous extract to synthesize silver nanoparticles (Ag-NPs) their potential combat TMV. Different techniques were used characterize Ag-NPs, such as scanning transmission electron microscopy (SEM, TEM), energy-dispersive X-ray spectroscopy (EDS), fourier transform infrared (FTIR), dynamic light scattering (DLS). Results TEM demonstrated biosynthesized Ag-NPs had spherical form with an average size 25 nm. The zeta indicated high stability value -15.9 mV. FTIR revealed various functional groups involved in capping Ag-NPs. Interestingly, Pre-treatment tobacco (protective treatment) at 100 or 500 µg/mL significantly suppressed viral symptoms, while Post-treatment (curative delayed appearance. Furthermore, protective curative treatments increased chlorophyll b, total flavonoids, soluble carbohydrates, antioxidant enzymes activity. At same time, it caused drop oxidative stress markers. RT-qPCR results volcano plots analysis showed triggers regulates transcriptional ten defense-related genes (SbWRKY-1, SbWRKY-2, JERF-3, GST-1, POD, PR-1, PR-2, PR-12, PAL-1, HQT-1). heatmap primary gene anthocyanidin production, was consistently most expressed across all throughout study. Analysis co-expression network SbWRKY-19 central among studied genes, followed by PR-12 PR-2. Conclusions Overall, reported antiviral properties and/or curative) against TMV lead us recommend simple, stable, eco-friendly agent developing pest management programs infections.

Язык: Английский

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