Nanotechnology-based non-invasive strategies in ocular therapeutics: Approaches, limitations to clinical translation, and safety concerns
Contact Lens and Anterior Eye,
Год журнала:
2025,
Номер
unknown, С. 102367 - 102367
Опубликована: Янв. 1, 2025
Язык: Английский
Insights into ocular therapeutics: A comprehensive review of anatomy, barriers, diseases and nanoscale formulations for targeted drug delivery
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
97, С. 105785 - 105785
Опубликована: Май 15, 2024
Язык: Английский
Exploring Non-Cytotoxic, Antioxidant, and Anti-Inflammatory Properties of Selenium Nanoparticles Synthesized from Gymnema sylvestre and Cinnamon cassia Extracts for Herbal Nanomedicine
Sumairan Bi Bi,
Iqra Elahi,
Nimra Sardar
и другие.
Microbial Pathogenesis,
Год журнала:
2024,
Номер
192, С. 106670 - 106670
Опубликована: Май 9, 2024
Язык: Английский
Ophthalmic In Situ Nanocomposite Gel for Delivery of a Hydrophobic Antioxidant
Gels,
Год журнала:
2025,
Номер
11(2), С. 105 - 105
Опубликована: Фев. 2, 2025
The
topical
administration
of
in
situ
hydrogels
for
ocular
pathologies
is
a
promising
application
strategy
providing
high
effectiveness
and
patient
compliance.
Curcumin,
natural
polyphenol,
possesses
all
the
prerequisites
successful
therapy
ophthalmic
diseases,
but
unfortunately
its
physicochemical
properties
hurdle
practical
use.
Applying
composite
thermoresponsive
hydrogel
formulation
embedded
with
polymer
nanoparticles
potent
to
overcome
identified
drawbacks.
In
present
work
we
prepared
uniform
spherical
(296.4
±
3.1
nm)
efficiently
loaded
curcumin
(EE%
82.5
2.3%)
based
on
biocompatible
biodegradable
poly-(lactic-co-glycolic
acid).
They
were
thoroughly
physicochemically
characterized
terms
FTIR,
SEM,
TGA,
DLS,
vitro
release
following
Fickian
diffusion
(45.62
2.37%),
stability
over
6
months.
Their
lack
cytotoxicity
was
demonstrated
HaCaT
cell
lines,
potential
antioxidant
protection
also
outlined,
starting
from
concentrations
as
low
0.1
µM
reaching
41%
at
5
µM.
An
(17%
w/v
poloxamer
407
0.1%
Carbopol)
suitable
optimized
respect
gelation
temperature
(31.40
0.36
°C),
gelling
time
(8.99
0.28
s)
upon
tears
dilution,
gel
erosion
(90.75
4.06%).
Upon
curcumin-loaded
nanoparticle
embedding,
appropriate
pseudoplastic
behavior
viscosity
35
°C
(2129
24
Pa∙s),
6-fold
increase
permeation,
prolonged
h.
Язык: Английский
The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 513 - 513
Опубликована: Апрель 14, 2025
Background/Objectives:
The
accurate
prediction
of
drug
release
profiles
from
Poly
(lactic-co-glycolic
acid)
(PLGA)-based
delivery
systems
is
a
critical
challenge
in
pharmaceutical
research.
Traditional
methods,
such
as
the
Korsmeyer-Peppas
and
Weibull
models,
have
been
widely
used
to
describe
vitro
kinetics.
However,
these
models
are
limited
by
their
reliance
on
fixed
mathematical
forms,
which
may
not
capture
complex
nonlinear
nature
behavior
diverse
PLGA-based
systems.
Method:
In
response
limitations,
we
propose
novel
approach—DrugNet,
data-driven
model
based
multilayer
perceptron
(MLP)
neural
network,
aiming
predict
data
at
unknown
time
points
fitting
curves
using
key
physicochemical
characteristics
PLGA
carriers
molecules,
well
data.
We
establish
dataset
through
literature
review,
trained
validated
determine
its
effectiveness
predicting
different
curves.
Results:
Compared
traditional
Korsmeyer–Peppas
semi-empirical
MSE
DrugNet
decreases
20.994
1.561,
respectively,
(R2)
increases
0.036
0.005.
Conclusions:
These
results
demonstrate
that
has
stronger
ability
fit
better
relationships
It
can
deal
with
change
better,
adaptability
advantages
than
overcomes
limitations
expressions
models.
Язык: Английский