Lipid Nanocarriers as Precision Delivery Systems for Brain Tumors
Bioconjugate Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Brain
tumors,
particularly
glioblastomas,
represent
the
most
complicated
cancers
to
treat
and
manage
due
their
highly
invasive
nature
protective
barriers
of
brain,
including
blood-brain
barrier
(BBB).
The
efficacy
currently
available
treatments,
viz.,
radiotherapy,
chemotherapy,
immunotherapy,
are
frequently
limited
by
major
side
effects,
drug
resistance,
restricted
penetration
into
brain.
Lipid
nanoparticles
(LNPs)
have
emerged
as
a
promising
targeted
delivery
system
for
brain
tumors.
nanocarriers
gained
tremendous
attention
tumor
therapeutics
multiple
encapsulation
abilities,
controlled
release,
better
biocompatibility,
ability
cross
BBB.
Herein,
detailed
analysis
design,
mechanisms,
therapeutic
benefits
LNPs
in
treatment
is
discussed.
Moreover,
we
also
discuss
safety
issues
clinical
developments
current
future
challenges.
Further,
focused
on
transformation
therapy
eliminating
effects
engineering
overcome
related
biological
barriers,
which
provide
personalized,
affordable,
low-risk
options.
Язык: Английский
Valorization of Arbutus unedo L. Pomace: Exploring the Recovery of Bioactive Phenolic Compounds from Distillation By-Products
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 278 - 278
Опубликована: Фев. 27, 2025
This
study
explores
the
potential
of
Arbutus
unedo
L.
pomace,
a
by-product
food
industry,
as
natural
ingredient
for
skincare
applications.
In
Portugal,
A.
fruits
are
traditionally
used
to
produce
"Aguardente
de
Medronho",
spirit
with
protected
geographical
indication.
The
distillation
process
generates
comprising
skins,
pulp
remnants,
seeds,
and
residual
alcohol
rich
in
phenolic
compounds,
whose
levels
significantly
increased
during
distillation.
addition
their
documented
high
antioxidant
content,
these
residues
also
display
notable
antimicrobial
properties.
However,
benefits
skin
health
have
not
yet
been
explored.
methodology
entailed
preparation
pomace
extract
comprehensive
analysis
its
polyphenolic
content
capacity
under
laboratory
conditions
preclinical
cellular
models.
by-products
demonstrated
polyphenol
potent
activity,
comparable
vitamin
C.
Bioscreening
on
human
models
(i.e.,
dermal
fibroblasts
keratinocytes)
revealed
ability
reduce
reactive
oxygen
species
(ROS)
formation
oxidative
stress
cells,
highlighting
mitigate
aging
damage
caused
by
environmental
pollutants.
Moreover,
bioscreens
vitro
safety
profile,
without
any
interference
cell
viability
at
concentrations
up
100
µg/mL.
These
findings
support
use
sustainable
development
antioxidant-rich
eco-friendly
cosmetic
or
dermatologic
products.
Язык: Английский
Microfluidic formulation of diazoxide-loaded solid lipid nanoparticles as a Novel approach for Friedreich's ataxia treatment
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
97, С. 105837 - 105837
Опубликована: Июнь 3, 2024
Friedreich
ataxia
(FRDA)
is
a
hereditary
autosomal
recessive
disorder
characterized
by
frataxin
deficiency,
impacting
mitochondrial
function
and
causing
oxidative
damage.
Diazoxide
(DZX),
vasodilating
drug
used
in
the
management
of
systemic
hypertension,
has
shown
promise
preclinical
models
but
faces
challenges
crossing
blood-brain
barrier
potential
toxicity
at
higher
doses.
This
study
aimed
to
create
solid
lipid
nanoparticles
(SLNs)
loaded
with
DZX
microfluidic
technique
improve
(BBB)
penetration
reduce
side
effects.
Employing
an
vitro
BBB
model,
SLN-DZX
demonstrated
enhanced
permeability
compared
plain
DZX.
Cell
viability
assays
carried
out
on
FRDA
fibroblast
cells
indicated
1
μM
SLN-DZX.
Cellular
uptake
studies
confirmed
SLN
internalization
fibroblasts,
subsequent
treatment
significantly
reduced
both
total
ROS
levels
control
empty
SLN-treated
cells.
These
findings
suggest
as
therapeutic
approach
for
FRDA,
mitigating
stress
improved
toxicity.
Язык: Английский
Chemical Profile and Promising Applications of Cucurbita pepo L. Flowers
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1476 - 1476
Опубликована: Ноя. 30, 2024
Although
edible
flowers
have
been
historically
principally
used
due
to
their
visual
appeal
and
smell,
the
world
is
discovering
value
as
innovative
natural
sources
of
bioactive
compounds.
Cucurbita
pepo
L.
(CpL),
a
plant
from
Cucurbitaceae
family,
widely
cultivated
for
its
fruits
flowers,
which
are
rich
in
polyphenols
carotenoids—compounds
known
potent
antioxidant
anti-inflammatory
properties.
Despite
potential,
use
CpL
skin-related
applications
remains
underexplored.
This
study
aimed
comprehensively
analyze
flower
extract
(CpLfe),
focusing
on
polyphenolic
carotenoid
content
using,
first
time,
advanced
UHPLC-Q-Orbitrap
HRMS
HPLC-DAD
analysis.
CpLfe
highlighted
remarkable
activity
according
DPPH,
ABTS,
FRAP
tests.
showed
significantly
reduced
intracellular
ROS
HaCaT
(23%,
p
<
0.05)
protected
against
UVB-induced
damage
by
lowering
MMP-1
expression.
also
upregulated
genes
crucial
skin
hydration
(AQP3)
barrier
function
(CerS2,
CerS4,
CerS6).
A
placebo-controlled,
randomized
clinical
trial
further
validated
efficacy,
demonstrating
marked
improvements
moisture
retention,
wrinkle
reduction,
collagen
production
women
aged
35–55.
These
findings
suggested
that
could
be
source
compounds
recovered
able
improve
major
aging
photoaging
features.
Язык: Английский
The Manufacturing and Characterisation of pentamidine-loaded poly(lactic-co-glycolic acid) nanoparticles produced by Microfluidic Method
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
100, С. 106063 - 106063
Опубликована: Авг. 12, 2024
Язык: Английский
Fabrication of Biomimetic Hybrid Liposomes via Microfluidic Technology: Homotypic Targeting and Antitumor Efficacy Studies in Glioma Cells
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 13217 - 13233
Опубликована: Дек. 1, 2024
The
treatment
of
glioblastoma
is
hindered
by
the
blood-brain
barrier
(BBB)
and
rapid
drug
clearance
immune
system.
To
address
these
challenges,
we
propose
a
novel
delivery
system
using
liposomes
modified
with
cell
membrane
fragments.
These
can
evade
system,
cross
BBB,
accumulate
in
tumor
tissue
through
homotypic
targeting,
thereby
delivering
drugs
like
paclitaxel
carboplatin
more
effectively.
Язык: Английский