Developing Engineered Nano-Immunopotentiators for the Stimulation of Dendritic Cells and Inhibition and Prevention of Melanoma

Pharmaceutical Research, Год журнала: 2024, Номер 41(6), С. 1163 - 1181

Опубликована: Июнь 1, 2024

Язык: Английский

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Targeted antibacterial and anticancer therapeutics: PEGylated liposomal delivery of turmeric and cinnamon extracts- in vitro and in vivo efficacy

Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 19

Опубликована: Фев. 4, 2025

This study presents the characterization and evaluation of polyethylene glycol (PEG)-coated liposomal formulations loaded with turmeric (TUR) cinnamon (CINN) extracts for treatment bacterial infections. TUR/CINN-loaded PEGylated liposomes enhance antibacterial effects TUR CINN both in vitro vivo. were synthesized using reverse-phase evaporation method characterized by dynamic light scattering spectrophotometry. The also evaluated biocompatibility, permeability, efficacy vivo environments. nanoparticles, dimensions ranging from 155 to 164 nm, exhibited consistent size distribution (polydispersity index (PDI) 0.219 0.23), stable zeta potentials (-20 -13 mV), effective drug encapsulation rates (86.8% 93.6%), suggesting their potential targeted delivery. In experiments demonstrated biocompatibility (cell viability exceeding 75% at 40 µg/mL), permeability (transfer 20.2% 21.5%), activity (minimum inhibitory concentrations 8 64 ability generate reactive oxygen species (1.2- 2-fold increase compared control). an murine model Pseudomonas aeruginosa skin infections, significant reductions viable counts observed, PEG-Lip-TUR/CINN leaving only 102 colony-forming units/mL. Additionally, this formulation displayed anti-metastatic properties, inhibiting cancer cell migration 99%. highlights as versatile therapeutic platforms antibiotic-resistant infections metastasis.

Язык: Английский

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How could the translation of nanotechnology-based therapies revolutionize cutaneous leishmaniasis treatments?

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 4

Опубликована: Март 26, 2025

Язык: Английский

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Nanoparticle-integrated metal–organic frameworks: a revolution in next-generation drug delivery systems

Journal of Pharmaceutical Investigation, Год журнала: 2024, Номер 54(6), С. 751 - 783

Опубликована: Авг. 2, 2024

Abstract Background Nanometal-organic frameworks (nano-MOFs), which exhibit distinctive features, such as controlled release mechanisms, stimuli-responsive behaviors, and sustained drug profiles, have emerged promising candidates for next-generation delivery systems. Area covered This review outlines the impact of nano-MOFs in biomedical applications, emphasizing their potential targeted through active strategies biocompatibility considerations. Expert opinion The versatility tunability pave way personalized medicine, allowing tailored formulations to meet individual patient needs. Despite transformative potential, challenges remain terms stability, toxicity assessment, standardization. As progress from laboratory research clinical trials, they present a paradigm shift delivery, offering precision medicine solutions theranostic platforms. future holds promise use revolutionize ushering an era effective therapeutic interventions.

Язык: Английский

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Synthesis, radiolabeling, and biodistribution of 99 m-technetium-labeled zif-8 nanoparticles for targeted imaging applications

3 Biotech, Год журнала: 2024, Номер 14(12)

Опубликована: Ноя. 8, 2024

Язык: Английский

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