Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
1Development of Paroxetine Loaded Nanotransferosomal Gel for Intranasal Delivery with Enhanced Antidepressant Activity in Rats
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 246, С. 114351 - 114351
Опубликована: Ноя. 7, 2024
Язык: Английский
Процитировано
6Microspheres: Preparation Methods, Advances, Applications, and Challenges in Drug Delivery
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
Язык: Английский
Процитировано
0Tailored Intranasal Albumin Caged Selegiline-α Synuclein siRNA Liposome with Improved Efficiency in Parkinson’s Model
Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 243 - 243
Опубликована: Фев. 12, 2025
Background/Objectives: Parkinson's disease (PD) is a progressive neuro-degenerative disorder characterized by α-synuclein aggregation, which promotes neuronal death and accelerates neurodegeneration. Small interfering RNA (siRNA) can reduce levels, but its therapeutic potential limited poor stability delivery challenges. Similarly, Selegiline (Sel), monoamine oxidase-B (MAO-B) inhibitor, has low bioavailability, restricting effectiveness. This study aims to develop an intranasal (IN) albumin-coated liposomal system (C-LipSel-siSNCA2) for the co-delivery of Sel α-synuclein-targeting siRNA (siSNCA2) enhance brain targeting efficacy. Methods: Liposomes were prepared using ethanol injection method optimized via D-optimal design size, charge, encapsulation efficiency (EE%). The formulation was coated with human serum albumin (HSA) stability, cellular uptake, gene silencing. In vivo pharmacokinetics pharmacodynamics assessed in rotenone-induced PD rat model evaluate motor function, biochemical markers, brain-targeting efficiency. Results: Optimized liposomes had particle size 113.5 ± 6.8 nm, zeta 6.2 0.8 mV, high EE% (Sel: 92.35%; siRNA: 78.66%). Albumin coating increased 136.5 10.3 nm shifted -13.5 1.4 enhancing targeting. IN administration achieved 3-fold increase area under concentration-time curve (AUC) versus intravenous delivery. rats, C-LipSel-siSNCA2 improved non-motor functions, restored dopamine enhanced catalase activity, reduced MAO-B mitigating degradation aggregation. Conclusions: non-invasive, dual-action nanoplatform offers targeted therapy PD, combining silencing inhibition, clinical translation neurodegenerative diseases.
Язык: Английский
Процитировано
0Nanoparticles induced health hazards through environmental exposure and direct contact
Proceedings of the Institution of Mechanical Engineers Part N Journal of Nanomaterials Nanoengineering and Nanosystems, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
The swift applications of nanoparticles (NPs) in different fields such as pharmaceuticals, semiconductor, and decontamination require a comprehensive evaluation their impacts on the health human beings. This critical review consolidates current knowledge nanoparticle toxicity with an attempt to unravel biochemical physiological processes by which NPs may harm health. Exposure routes including aspiration, skin permeation, direct consumption are involved especially assessed terms biodistribution biokinetics living organisms. An exploration physico-chemical characteristics particle size, morphology, surface charge, chemical make-up yields fact that all those things play important role regulation relation other include cell uptake, generation oxidative stress, inflammation. New data define linkages between NP exposure respiratory cardiovascular diseases, Neurotoxicity, potential carcinogenicity. further relies present methodological deficiencies lack harmonization existing assessments for chronic risks call more standardized testing protocols elaborate long-term epidemiological investigations. goal this is highlight hazards associated nanoparticles. In addition, authors also tried contribute regulatory guidance directions design safer nanomaterials will help protect population at dawn nanotechnologies.
Язык: Английский
Процитировано
0Nanotechnology-driven Microemulsion Based Intranasal Delivery to Neurotechnology-driven Neuralink: Strategies to Improve Management of Neurodegenerative Disorders
AAPS PharmSciTech, Год журнала: 2024, Номер 25(7)
Опубликована: Сен. 12, 2024
Язык: Английский
Процитировано
1Optimizing nasal drug delivery for peptides, proteins, and small molecules: strategic use of materials and techniques to target the CNS
International Journal of Polymeric Materials, Год журнала: 2024, Номер unknown, С. 1 - 24
Опубликована: Дек. 20, 2024
Nasal delivery of therapeutics has garnered noteworthy attention for the treatment neurological diseases due to its noninvasive nature and ability administer large molecules like peptides proteins small molecules. Numerous benefits are associated with nasal mucosa, such as facilitate quick absorption, avoidance first-pass metabolism, simplicity administration. However, efficient transportation over mucosa remains challenging many physiological constraints. This review article explores techniques enhance peptides, proteins, across a particular emphasis on careful selection utilization materials mechanisms. Peptides, can be carried more efficiently using variety means, including modifying drug properties, co-delivery systems, employing physical chemical techniques, implementing targeted strategies. The highlights existing obstacles constraints, possible uses, future pathways in domain delivery. A thorough analysis methods used transporting through is discussed.
Язык: Английский
Процитировано
1Novel Technologies in PROTAC Design
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
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