Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic Applications

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Янв. 17, 2025

Язык: Английский

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Non-Coding RNAs in Urinary Bladder Cancer Microenvironment: Diagnostic, Therapeutic, and Prognostic Perspective

Pathology - Research and Practice, Год журнала: 2025, Номер 266, С. 155815 - 155815

Опубликована: Янв. 9, 2025

Язык: Английский

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Apoptosis in polycystic ovary syndrome: Mechanisms and therapeutic implications

Life Sciences, Год журнала: 2025, Номер 363, С. 123394 - 123394

Опубликована: Янв. 13, 2025

Язык: Английский

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Future prospective of AI in drug discovery

Advances in pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Deep Learning in Oncology: Transforming Cancer Diagnosis, Prognosis, and Treatment

Emerging Trends in Drugs Addictions and Health, Год журнала: 2025, Номер unknown, С. 100171 - 100171

Опубликована: Фев. 1, 2025

Язык: Английский

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Exploring the Molecular Interactions Between Ferroptosis and the Wnt/β-Catenin Signaling Pathway: Implications for Cancer and Disease Therapy

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104674 - 104674

Опубликована: Фев. 1, 2025

Язык: Английский

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Novel insights into taxane pharmacology: an update on drug resistance mechanisms, immunomodulation and drug delivery strategies

Drug Resistance Updates, Год журнала: 2025, Номер 81, С. 101223 - 101223

Опубликована: Март 8, 2025

Taxanes are effective in several solid tumors. Paclitaxel, the main clinically available taxane, was approved early nineties, for treatment of ovarian cancer and later on, together with analogs docetaxel cabazitaxel, other malignancies. By interfering microtubule function impairing separation sister cells at mitosis, taxanes act as antimitotic agents, thereby counteracting high proliferation rate cells. The action goes beyond their because cellular targets, microtubules, participate multiple processes such intracellular transport cell shape maintenance. clinical efficacy is limited by development resistance mechanisms. Among these, extracellular vesicles have emerged new players. In addition, taxane metronomic schedules shows an impact on tumor microenvironment reflected antiangiogenic immunomodulatory effects, aspect growing interest considering inclusion regimens immunotherapeutics. Preclinical studies paved bases synergistic combinations both conventional targeted agents. A variety drug delivery strategies provided novel opportunities to increase activity. ability orchestrate different effects amenable modulation suggests options improve cures lethal

Язык: Английский

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Polymeric Nanoparticles in Targeted Drug Delivery: Unveiling the Impact of Polymer Characterization and Fabrication

Polymers, Год журнала: 2025, Номер 17(7), С. 833 - 833

Опубликована: Март 21, 2025

Polymeric nanoparticles (PNPs) represent a groundbreaking advancement in targeted drug delivery, offering significant benefits over conventional systems. This includes their versatility, biocompatibility, and ability to encapsulate diverse therapeutic agents provide controlled release, improving efficacy while minimizing side effects. The polymers used PNP formulations are critical, as they influence the nanoparticles' physicochemical properties such size, shape, surface charge, drug-loading capacity. Recent developments polymer chemistry nanotechnology have led creation of smart PNPs that can respond specific stimuli, enabling precise release environments. review explores mechanisms innovations polymeric formulations, fabrication characterization techniques enhance delivery Additionally, it discusses challenges future directions field, highlighting potential for personalized medicine role artificial intelligence optimizing nanoparticle design. By examining relationship between characteristics performance, aims promote innovative strategies modern medicine. Despite promise polymer-based systems, toxicity, stability, scalability, regulatory compliance must be addressed. Future research should focus on rigorous testing, clear risk communication, sustainable practices support clinical translation commercial viability. Overall, integration these elements is crucial advancing applications.

Язык: Английский

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Smart nanomedicines powered by artificial intelligence: a breakthrough in lung cancer diagnosis and treatment

Medical Oncology, Год журнала: 2025, Номер 42(5)

Опубликована: Март 25, 2025

Язык: Английский

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Advances in Nanoparticles in Targeted Drug Delivery- A Review

Results in Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 100529 - 100529

Опубликована: Апрель 1, 2025

Язык: Английский

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