Piperine and its nanoformulations: A mechanistic review of their anti-cancer activities

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 187, С. 118075 - 118075

Опубликована: Апрель 23, 2025

Язык: Английский

Integrating the metabolic and molecular circuits in diabetes, obesity and cancer: a comprehensive review

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 18, 2024

The progressive globalization of sedentary lifestyles and diets rich in lipids processed foods has caused two major public health hazards-diabetes obesity. strong interlink between obesity type 2 diabetes mellitus their combined burden encompass them into a single term 'Diabesity'. They have also been tagged as the drivers for onset cancer. clinical association diabetes, obesity, several types human cancer demands an assessment vital junctions correlating three. This review focuses on revisiting molecular axis linking to through pathways that get imbalanced owing metabolic upheaval. We attempt describe functional disruptions DNA repair mechanisms due overwhelming oxidative damage by diabesity. Genomic instability, known hallmark results when does not work optimally, will be inferred from this obtruded homeostasis creates favorable microenvironment supporting reprogramming enabling malignancies. Altered hormonal landscapes these morbidities provide novel connection metabolomics oncogenesis. Understanding various aspects tumorigenic process diabesity-induced cancers might help discovery new biomarkers prompt targeted therapeutic interventions.

Язык: Английский

A review of randomized phase III clinical trials of cancer nanomedicines

Cancer Pathogenesis and Therapy, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский