Fabrication of oral sustained release capecitabine loaded nanostructured lipid carriers with improved bioavailability and prolonged anticancer effects

Journal of Molecular Liquids, Год журнала: 2025, Номер 421, С. 126852 - 126852

Опубликована: Янв. 5, 2025

Язык: Английский

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Development of Paroxetine Loaded Nanotransferosomal Gel for Intranasal Delivery with Enhanced Antidepressant Activity in Rats

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 246, С. 114351 - 114351

Опубликована: Ноя. 7, 2024

Язык: Английский

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A thermoresponsive system of niclosamide for colon specific delivery in ulcerative colitis: Bioavailability and safety investigation

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106641 - 106641

Опубликована: Янв. 1, 2025

Язык: Английский

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Improved biopharmaceutical performance of chlorpromazine-nanostructured lipid carriers: In vitro release, pharmacokinetics and toxicity testing

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106885 - 106885

Опубликована: Апрель 1, 2025

Язык: Английский

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Thermoresponsive biomaterial system of Irinotecan and Curcumin for the treatment of colorectal cancer: In-vitro and in-vivo investigations

Pharmaceutical Development and Technology, Год журнала: 2024, Номер 30(1), С. 37 - 56

Опубликована: Дек. 27, 2024

This study aims to develop a thermoresponsive biomaterial system of irinotecan (IRT) and curcumin (CUR) nano-transferosomal gel (IRT-CUR-NTG) for targeting colorectal cancer (CRC). The IRT-CUR-NTs were statistically optimized loaded into poloxamer-based thermosensitive gel. Transmission electron microscopy (TEM), Differential scanning calorimetry (DSC) Fourier-transform infrared spectroscopy (FTIR) the performed, whereas pH, gelation time, temperature, mucoadhesive strength IRT-CUR-NTG investigated. In-vitro release anticancer analyses explored using HT29 cells. Additionally, in-vivo pharmacokinetics was investigated followed by histopathological examination analysis. PS, PDI, ZP, %EE IRT CUR found be 136.15 nm, 0.143, -15.5 mV, 95.05% 85.12%, respectively. exhibited spherical shape with no chemical interactions among constituents. Similarly, homogenous suitable rectal administration. manifested prolonged profiles CUR. Moreover, significantly enhanced (4-fold) bioavailability toxicity observed when compared conventional more effective against cell lines. In-vivo antitumor analysis demonstrated reduced tumor volume mass after treatment IRT-CUT-NTG, indicating improved effect. It can concluded that is cancer.

Язык: Английский

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Elucidating the Role of Transferosomes as a Promising Platform for Management of Various Types of Arthritis: A Comprehensive Review

BioNanoScience, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 2, 2024

Язык: Английский

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