Nanomedicine: a cost-effective and powerful platform for managing neurodegenerative diseases

Metabolic Brain Disease, Год журнала: 2025, Номер 40(3)

Опубликована: Март 11, 2025

Язык: Английский

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Mini Review on the Lyophilization: A Basic Requirement for Formulation Development and Stability Modifier

Assay and Drug Development Technologies, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Freeze-drying is popular for producing pharmaceutical formulations with structurally complicated active components and drug delivery system carriers. It the process of eliminating water from ice crystals through sublimation mechanism. Some may require drug-specific excipients such as stabilizers, buffers, bulking agents to maintain appearance assure long-term stability product. This approach utilized therapeutic compounds that are moisture sensitive, thermolabile, degrade in atmosphere. Freezing primary secondary drying critical processes lyophilization because they directly impact end result. effective a variety dosage forms, including oral, inhalation, parenteral. As result, be an important method improving efficacy various forms delivered via different routes. Additionally, used pharmacological research preserve biological samples, stabilize reference/standards, increase solubility bioavailability poorly soluble drugs. Thus, maintaining stability, efficacy, safety products throughout their development lifecycles. article includes broad overview process, principle, lyophilized medicine compositions, new technologies well applications fields.

Язык: Английский

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Freeze-Drying as a Tool for Preparing Porous Materials: From Proof of Concept to Recent Pharmaceutical Applications

AAPS PharmSciTech, Год журнала: 2025, Номер 26(5)

Опубликована: Июнь 3, 2025

Язык: Английский

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