Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 290 - 290
Опубликована: Фев. 20, 2025
Objectives:
This
study
aimed
to
develop
hesperidin
solid
lipid
nanoparticles
(HESP-SLNs)
enhance
their
stability,
solubility,
and
sustained
release
for
wound
healing;
further
enhancement
was
achieved
through
prepared
nanostructured
carriers
(HESP-NLCs)
using
Tea
Tree
Oil
(TTO)
explore
synergistic
efficacy.
Methods:
A
factorial
design
of
24
trials
established
evaluate
the
influence
type
(X1),
conc
(%)
(X2),
surfactant
(X3),
sonication
amplitude
(X4)
HESP-SLNs
on
particle
size
(nm)
(Y1),
polydispersibility
index
(Y2),
zeta
potential
(Y3),
encapsulation
efficiency
(Y4).
The
optimized
formula
selected
utilizing
Design
Expert®
software
version
13,
which
additionally
enhanced
by
preparing
TTO-loaded
HESP-NLCs.
In
vitro
release,
Raman
spectroscopy,
transmission
electron
microscopy
were
carried
out
both
nanoparticles.
Cytotoxicity,
in
vivo
wound-healing
assessments,
skin
irritancy
tests
performed
performance
TTO-incorporated
HESP-NLCs
compared
HESP-SLNs.
Results:
demonstrated
PS
(280
±
1.35
nm),
ZP
(−39.4
0.92
mV),
PDI
(0.239
0.012),
EE%
(88.2
2.09%).
NLCs
Q6%
(95.14%)
vs.
(79.69%),
SLNs
showed
superior
antimicrobial
Both
exhibited
spherical
morphology
compatibility
between
HESP
excipients.
highest
closure
percentage,
supported
histological
analysis
inflammatory
biomarker
outcomes.
Cytotoxicity
evaluation
87%
cell
viability
untreated
HSF
cells,
test
confirmed
safety
NLCs.
Conclusions:
are
promising
candidates
exhibiting
capabilities,
making
them
a
therapeutic
option
cutaneous
management.
Язык: Английский
Formulation, development and in vivo characterization of selegiline hydrochloride nanostructured lipid nanocarrier loaded microneedle array patch for depression
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
671, С. 125257 - 125257
Опубликована: Янв. 22, 2025
Язык: Английский
Formulation Design and Evaluation of Ginsenoside Compound K Nanostructured Lipid Carriers Based on Molecular Dynamics Simulations
Journal of Pharmaceutical Innovation,
Год журнала:
2024,
Номер
19(6)
Опубликована: Дек. 1, 2024
Язык: Английский
Evaluation of betanin‐loaded liposomal nanocarriers in AlCl3‐induced Alzheimer's disease in rats: Impact on cognitive function, neurodegeneration, and TREM2/ADAM10 pathways
Archiv der Pharmazie,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Abstract
Betanin
(BET)
has
been
studied
for
its
therapeutic
benefits
in
various
diseases,
but
low
bioavailability
and
uncertain
brain
penetration
limit
efficacy.
Accordingly,
this
study
aimed
to
explore
BET‐loaded
liposomal
nanocarriers
(LPN)
as
a
novel
treatment
Alzheimer's
disease
(AD),
focusing
on
the
triggering
receptor
expressed
myeloid
cells
2
(TREM2)/DNAX‐activating
protein
of
12
kDa
(DAP12)
extracellular
signal‐regulated
kinase
1/2
(ERK1/2)
pathways
implicated
AD.
In
an
AlCl
3
‐induced
AD
rat
model,
48
male
Wistar
rats
were
divided
into
four
groups:
control,
(50
mg/kg,
intraperitoneal),
+BET
(100
per
os),
LPN
(25
intranasally),
with
treatments
administered
28
days.
Morris
water
maze
test
histopathological
examination
showed
that
BET
LPN‐treated
had
improved
spatial
learning
memory
less
hippocampal
cortical
degeneration
compared
oral
groups.
Mechanistically,
corrected
biomarkers,
increased
miR‐132
ADAM10
expression,
reduced
oxidative
stress,
inflammation,
apoptosis.
Additionally,
suppressed
expression
TREM2,
DAP12,
ERK1/2,
mitogen‐activated
(MEK1/2),
showing
greater
improvement
than
BET.
These
findings
suggest
enhances
cognitive
function
neuroprotection
by
modulating
inhibiting
ERK1/2
TREM2/DAP12
pathways,
providing
more
effective
traditional
administration.
Язык: Английский