Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases DOI Creative Commons

Suraj Wagh,

Paras Famta,

Saurabh Shah

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер 20(2), С. 101040 - 101040

Опубликована: Фев. 27, 2025

Cellular hitchhiking is an emerging therapeutic strategy that uses endogenous cell migration mechanism to deliver therapeutics specific sites in the body. Owing low permeability and presence of blood-brain barrier (BBB), targeted delivery limited, leading inadequate localization brain. NCs fail extravasate significantly into tumor microenvironment (TME), demonstrating poor accumulation penetration. The novel cellular concept has been utilized promote systemic half-life targeting. Neoplastic neuroinflammatory diseases brain, including glioblastoma neuroinflammation, face critical hurdles for efficiently delivering entities owing BBB. can surmount these by utilizing various populations, such as stem cells, monocytes/macrophages, neutrophils, platelets, potential functional carriers cargo through These carrier cells have innate capability traverse BBB, transit brain parenchyma, specifically reach disease inflammatory neoplastic lesions chemotactic navigation, i.e., movement attributed chemical stimuli. Chemotherapeutic drugs delivered achieve tumor-specific targeting discussed. This article explores types TME with in-depth mechanisms characterization techniques decipher backpack dissociation dynamics (nanoparticle payload detachment characteristics from hitchhiked cells) challenges toward prospective clinical translation.

Язык: Английский

Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases DOI Creative Commons

Suraj Wagh,

Paras Famta,

Saurabh Shah

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер 20(2), С. 101040 - 101040

Опубликована: Фев. 27, 2025

Cellular hitchhiking is an emerging therapeutic strategy that uses endogenous cell migration mechanism to deliver therapeutics specific sites in the body. Owing low permeability and presence of blood-brain barrier (BBB), targeted delivery limited, leading inadequate localization brain. NCs fail extravasate significantly into tumor microenvironment (TME), demonstrating poor accumulation penetration. The novel cellular concept has been utilized promote systemic half-life targeting. Neoplastic neuroinflammatory diseases brain, including glioblastoma neuroinflammation, face critical hurdles for efficiently delivering entities owing BBB. can surmount these by utilizing various populations, such as stem cells, monocytes/macrophages, neutrophils, platelets, potential functional carriers cargo through These carrier cells have innate capability traverse BBB, transit brain parenchyma, specifically reach disease inflammatory neoplastic lesions chemotactic navigation, i.e., movement attributed chemical stimuli. Chemotherapeutic drugs delivered achieve tumor-specific targeting discussed. This article explores types TME with in-depth mechanisms characterization techniques decipher backpack dissociation dynamics (nanoparticle payload detachment characteristics from hitchhiked cells) challenges toward prospective clinical translation.

Язык: Английский

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