Research progress on biodegradable polymer-based drug delivery systems for the treatment of knee osteoarthritis DOI Creative Commons
Jinchi Zhang, Jinchao Zhang, Hailong Li

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 10, 2025

Knee osteoarthritis (KOA) is a disease that involves multiple anatomical and physiological changes in the knee tissues, including cartilage degeneration, bone remodelling formation of bony encumbrances, which leads to clinical manifestations pain, stiffness, swelling limitation function. chronic joint characterised by degenerative lesions secondary osteophytes joint. The symptoms tend progress slowly, at this stage, number patients with KOA increasing. However, due adverse effects poor therapeutic outcomes following surgical treatment, intervention therapy through utilisation biodegradable polymeric materials required. Currently, aspects are mainly used treat degeneration using different kinds biopolymer excellent physical properties, histocompatibility other combined drug delivery system, can reduce level inflammation stiffness focal area, maximise restoration patient's mobility athletic ability. Based on properties material has variable loading capacity encapsulates hydrophobic/hydrophilic drugs controls release kinetics regulating composition charge. This paper reviews research Poly (ε-caprolactone) (PCL), Poly(lactic acid) (PLA), (lactic glycolic (PLGA), Poly(ethylene glycol) (PEG) synthetic polymers collagen, chondroitin sulfate, natural based systems for treatment osteoarthritis, explains have been widely osteoarthritis. there still issues degradability, toxicity, compatibility, durability safety system degradable need be addressed further trials. As biomedical continue explored, eventually idealized will stand out KOA.

Язык: Английский

Antibacterial, Angiogenic and Irritation Evaluation of Mupirocin-loaded silk fibroin hydrogel DOI
Tanapong Watchararot,

Nopparuj Soomherun,

Jirasak Jitpibull

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106910 - 106910

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Research progress on biodegradable polymer-based drug delivery systems for the treatment of knee osteoarthritis DOI Creative Commons
Jinchi Zhang, Jinchao Zhang, Hailong Li

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 10, 2025

Knee osteoarthritis (KOA) is a disease that involves multiple anatomical and physiological changes in the knee tissues, including cartilage degeneration, bone remodelling formation of bony encumbrances, which leads to clinical manifestations pain, stiffness, swelling limitation function. chronic joint characterised by degenerative lesions secondary osteophytes joint. The symptoms tend progress slowly, at this stage, number patients with KOA increasing. However, due adverse effects poor therapeutic outcomes following surgical treatment, intervention therapy through utilisation biodegradable polymeric materials required. Currently, aspects are mainly used treat degeneration using different kinds biopolymer excellent physical properties, histocompatibility other combined drug delivery system, can reduce level inflammation stiffness focal area, maximise restoration patient's mobility athletic ability. Based on properties material has variable loading capacity encapsulates hydrophobic/hydrophilic drugs controls release kinetics regulating composition charge. This paper reviews research Poly (ε-caprolactone) (PCL), Poly(lactic acid) (PLA), (lactic glycolic (PLGA), Poly(ethylene glycol) (PEG) synthetic polymers collagen, chondroitin sulfate, natural based systems for treatment osteoarthritis, explains have been widely osteoarthritis. there still issues degradability, toxicity, compatibility, durability safety system degradable need be addressed further trials. As biomedical continue explored, eventually idealized will stand out KOA.

Язык: Английский

Процитировано

0