Sodium–Glucose Cotransporter 2 Inhibitors as Potential Antioxidant Therapeutic Agents in Cardiovascular and Renal Diseases DOI Creative Commons
Tapan Patel, Hong Zheng, Kaushik P. Patel

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 336 - 336

Опубликована: Март 13, 2025

Redox (reduction-oxidation) imbalance is a physiological feature regulated by well-maintained equilibrium between reactive oxygen species (ROS) and oxidative stress (OS), the defense system of body (antioxidant enzymes). The redox comprises levels ROS in cells, tissues overall organ system. are synchronized gradients electrons that generated due to sequential reduction oxidation various biomolecules enzymes. Such reactions present each cell, irrespective any tissue or organ. Failure such coordinated regulation leads production excessive free radicals. Excessively produced radicals affect cellular molecular processes required for cell survival growth, leading pathophysiological conditions and, ultimately, failure. Overproduction key factors involved onset progression associated with cardiovascular renal diseases. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) glucose-lowering drugs prescribed diabetic patients. Interestingly, apart from their effect, these exhibit beneficial effects non-diabetic patients suffering chronic kidney diseases, perhaps antioxidant properties. Recently, it has been demonstrated SGLT2is strong properties reducing OS. Hence, this review, we aim novel role consequent disease states.

Язык: Английский

Sodium–Glucose Cotransporter 2 Inhibitors as Potential Antioxidant Therapeutic Agents in Cardiovascular and Renal Diseases DOI Creative Commons
Tapan Patel, Hong Zheng, Kaushik P. Patel

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 336 - 336

Опубликована: Март 13, 2025

Redox (reduction-oxidation) imbalance is a physiological feature regulated by well-maintained equilibrium between reactive oxygen species (ROS) and oxidative stress (OS), the defense system of body (antioxidant enzymes). The redox comprises levels ROS in cells, tissues overall organ system. are synchronized gradients electrons that generated due to sequential reduction oxidation various biomolecules enzymes. Such reactions present each cell, irrespective any tissue or organ. Failure such coordinated regulation leads production excessive free radicals. Excessively produced radicals affect cellular molecular processes required for cell survival growth, leading pathophysiological conditions and, ultimately, failure. Overproduction key factors involved onset progression associated with cardiovascular renal diseases. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) glucose-lowering drugs prescribed diabetic patients. Interestingly, apart from their effect, these exhibit beneficial effects non-diabetic patients suffering chronic kidney diseases, perhaps antioxidant properties. Recently, it has been demonstrated SGLT2is strong properties reducing OS. Hence, this review, we aim novel role consequent disease states.

Язык: Английский

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