Therapeutic Potential of Local and Systemic Adipose-Derived Mesenchymal Stem Cell Injections in a Rat Model of Experimental Periodontitis: Implications for Cardiac Function DOI Open Access

Asmaa Elhaieg,

Ahmed Farag, Sai Koung Ngeun

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 3984 - 3984

Опубликована: Апрель 23, 2025

Periodontitis is a common inflammatory disease that not only damages periodontal tissues but also induces systemic effects, including cardiac dysfunction. Mesenchymal stem cells (MSCs) offer regenerative potential due to their ability differentiate, modulate immune responses, and secrete anti-inflammatory factors. However, the relative efficacy of local versus MSC administration remains unclear. This study evaluated therapeutic effects adipose-derived MSCs (AD-MSCs) in rat model experimental periodontitis, comparing administration. AD-MSCs were characterized based on morphology, surface marker expression, differentiation potential. Ligature-induced periodontitis was established over 60 days, after which (1 × 106 cells) administered either supraperiosteally (local group) or intravenously (systemic group). Periodontal regeneration assessed through clinical, radiographic, histopathological analyses, while function using echocardiography examinations. Results demonstrated AD-MSC provided superior benefits compared delivery. Locally significantly enhanced bone regeneration, reduced inflammation, improved tissue architecture. In contrast, offered moderate less effective restoring integrity. Similarly, heart, treatment resulted greater improvements systolic function, as indicated by ejection fraction fractional shortening, along with myocardial fibrosis. Although cardioprotective diastolic dysfunction persisted both groups. conclusion, proved more regenerating mitigating dysfunction, highlighting its an optimized strategy for complications.

Язык: Английский

Therapeutic Potential of Local and Systemic Adipose-Derived Mesenchymal Stem Cell Injections in a Rat Model of Experimental Periodontitis: Implications for Cardiac Function DOI Open Access

Asmaa Elhaieg,

Ahmed Farag, Sai Koung Ngeun

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 3984 - 3984

Опубликована: Апрель 23, 2025

Periodontitis is a common inflammatory disease that not only damages periodontal tissues but also induces systemic effects, including cardiac dysfunction. Mesenchymal stem cells (MSCs) offer regenerative potential due to their ability differentiate, modulate immune responses, and secrete anti-inflammatory factors. However, the relative efficacy of local versus MSC administration remains unclear. This study evaluated therapeutic effects adipose-derived MSCs (AD-MSCs) in rat model experimental periodontitis, comparing administration. AD-MSCs were characterized based on morphology, surface marker expression, differentiation potential. Ligature-induced periodontitis was established over 60 days, after which (1 × 106 cells) administered either supraperiosteally (local group) or intravenously (systemic group). Periodontal regeneration assessed through clinical, radiographic, histopathological analyses, while function using echocardiography examinations. Results demonstrated AD-MSC provided superior benefits compared delivery. Locally significantly enhanced bone regeneration, reduced inflammation, improved tissue architecture. In contrast, offered moderate less effective restoring integrity. Similarly, heart, treatment resulted greater improvements systolic function, as indicated by ejection fraction fractional shortening, along with myocardial fibrosis. Although cardioprotective diastolic dysfunction persisted both groups. conclusion, proved more regenerating mitigating dysfunction, highlighting its an optimized strategy for complications.

Язык: Английский

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