Bioactive Materials, Год журнала: 2024, Номер 40, С. 104 - 147
Опубликована: Июнь 8, 2024
Язык: Английский
Molecules, Год журнала: 2021, Номер 26(10), С. 3007 - 3007
Опубликована: Май 18, 2021
After tooth loss, bone resorption is irreversible, leaving the area without adequate volume for successful implant treatment. Bone grafting only solution to reverse dental loss and a well-accepted procedure required in one every four implants. Research development materials, design fabrication technologies have expanded over years achieve long-lasting implants substitution. This review will critically present various graft substitute materials that been used implant. The article also reviews properties of grafts substitutes studied or are currently available commercially. classifications substitutes, including natural synthetic presented, commercial products each category discussed. Different metals, ceramics, polymers, their combinations, chemical, physical, biocompatibility explored. Limitations areas which require further research highlighted. Tissue engineering hybrid constructions with enhanced regeneration ability, such as cell-based growth factor-based discussed an emerging development.
Язык: Английский
Процитировано
426
Materials, Год журнала: 2023, Номер 16(11), С. 4117 - 4117
Опубликована: Май 31, 2023
This review provides an overview of various materials used in dentistry and oral maxillofacial surgeries to replace or repair bone defects. The choice material depends on factors such as tissue viability, size, shape, defect volume. While small defects can regenerate naturally, extensive loss pathological fractures require surgical intervention the use substitute bones. Autologous bone, taken from patient's own body, is gold standard for grafting but has drawbacks uncertain prognosis, surgery at donor site, limited availability. Other alternatives medium small-sized include allografts (from human donors), xenografts animals), synthetic with osteoconductive properties. Allografts are carefully selected processed materials, while derived animals possess similar chemical composition bone. Synthetic ceramics bioactive glasses may lack osteoinductivity moldability. Calcium-phosphate-based ceramics, particularly hydroxyapatite, extensively studied commonly due their compositional similarity natural Additional components, growth factors, autogenous therapeutic elements, be incorporated into xenogeneic scaffolds enhance osteogenic aims provide a comprehensive analysis dentistry, discussing properties, advantages, disadvantages. It also highlights challenges analyzing vivo clinical studies select most suitable option specific situations.
Язык: Английский
Процитировано
104
Applied Sciences, Год журнала: 2023, Номер 13(14), С. 8471 - 8471
Опубликована: Июль 22, 2023
The ideal biomaterials substitute for bone repair should possess the following characteristics: provide osteogenic, osteoinductive and osteoconductive properties; stimulate neo-angiogenesis process; absence of antigenic, teratogenic or carcinogenic reactions; avoid systemic toxicity complications; assure satisfactory support stability from mechanical properties point view; hydrophilic nature surface good interface with human bone; handling in clinical condition ability to be easy sterilized; able supplied sufficient quantities reduced costs. Despite years effort, perfect reconstruction material has not yet been developed; further effort is required make this objective feasible. aim article a contemporary comprehensive overview grafting materials that can applied treatment defects by clinicians orthopedics surgery, neurosurgery dentistry, discussing their properties, advantages disadvantages, illuminating present future perspectives field graft substitutes repair, needs advanced research.
Язык: Английский
Процитировано
54
European Polymer Journal, Год журнала: 2024, Номер 215, С. 113251 - 113251
Опубликована: Июнь 19, 2024
Meeting the escalating demands in biomedical applications has spurred creation of diverse scaffolds, where selection materials and manufacturing techniques stands as a linchpin fostering bone tissue formation. These scaffolds provide fundamental structural framework that supports cell growth differentiation. It is vital for repair, addressing various biological requisites such biocompatibility, biodegradability, mechanical properties becomes imperative. This comprehensive review discusses recent advancements 3D tailored specifically engineering applications. Stereolithography, fused deposition modelling, selective laser sintering, binder jetting, electron beam melting, bioprinting (including laser-based, inkjet extrusion bioprinting) are meticulously explored. Focusing on their respective applications, limitations, well advantages disadvantages within context regeneration. Furthermore, article underscores pivotal role material potential solution to address challenges associated with grafts. emphasizes need nuanced understanding significant considerations regardless type when designing or evaluating suitability integration into expansive realm engineering.
Язык: Английский
Процитировано
25
Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 291 - 291
Опубликована: Фев. 18, 2024
Bone defects represent an everyday challenge for clinicians who work in the fields of orthopedic surgery, maxillofacial and oral otorhinolaryngology, dental implantology. Various bone substitutes have been developed utilized, according to needs reconstructive surgery. Carbonate apatite has gained popularity recent years, due its excellent tissue behavior osteoconductive potential. This systematic review aims evaluate role carbonate surgery engineering, analyze advantages limitations, suggest further directions research development. The Web Science, PubMed, Scopus electronic databases were searched relevant articles, published from January 2014 21 July 2023. study was conducted accordance with Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. Eighteen studies included present review. biological properties medical applications (CO3Ap) are discussed evaluated. majority articles demonstrated that CO3Ap biocompatibility, resorbability, osteoconductivity. Furthermore, it resembles causes minimal immunological reactions. Therefore, may be successfully utilized various applications, such as substitution, scaffolding, implant coating, drug delivery, engineering.
Язык: Английский
Процитировано
20
Journal of Clinical Medicine, Год журнала: 2020, Номер 9(1), С. 139 - 139
Опубликована: Янв. 4, 2020
The deterioration of the human skeleton's capacity for self-renewal occurs naturally with age. Osteoporosis affects millions worldwide, current treatments including pharmaceutical agents that target bone formation and/or resorption. Nevertheless, these clinical approaches often result in long-term side effects, better alternatives being constantly researched. Mesenchymal stem cells (MSCs) derived from marrow and adipose tissue are known to hold therapeutic value treatment a variety diseases. following review summarizes latest studies trials related use MSCs, both individually combined other methods, conditions skeletal health. For example, some most recent works noted advantage grafts based on biomimetic scaffolds MSC growth factor delivery, greatly increased regeneration rate minimized effects patients. This also highlights continuing research into mechanisms underlying homeostasis, key transcription factors signalling pathways responsible regulating differentiation osteoblast lineage. Paracrine specific miRNAs believed play part differentiation. Furthering understanding cellular remodelling is incorporating new effective methods disease.
Язык: Английский
Процитировано
74
Scientific Reports, Год журнала: 2021, Номер 11(1)
Опубликована: Янв. 12, 2021
Abstract The clinical use of bioactive molecules in bone regeneration has been known to have side effects, which result from uncontrolled and supraphysiological doses. In this study, we demonstrated the synergistic effect two molecules, morphogenic protein-2 (BMP-2) alendronate (ALN), by releasing them a sequential manner. Collagen-hydroxyapatite composite scaffolds functionalized using BMP-2 are loaded with biodegradable microspheres where ALN is encapsulated. results indicate an initial release for few days, followed after weeks. significantly increase osteogenic activity owing ALN. Enhanced was identified at eight weeks post-implantation rat 8-mm critical-sized defect. Our findings suggest that delivery on regeneration, unprecedented. Therefore, such system exhibits potential application cell-free tissue engineering.
Язык: Английский
Процитировано
70
Materials, Год журнала: 2022, Номер 15(3), С. 1120 - 1120
Опубликована: Янв. 31, 2022
For decades, regenerative medicine and dentistry have been improved with new therapies innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review recent innovations in field bone regeneration focus on healing potentials protocols substitutes combined engineered constructs, growth factors photobiomodulation applications. A Boolean systematic search conducted by PubMed/Medline, PubMed/Central, Web Science Google scholar databases according PRISMA guidelines. After initial screening, total 304 papers were considered eligible for qualitative synthesis. articles included categorized main topics: alloplastic substitutes, autologous teeth derived xenografts, platelet-derived concentrates, laser therapy, microbiota metabolism mesenchymal cells construct. effectiveness showed that use biocompatible bio-resorbable are related high-predictability protocols, while oral systemic health patient produce advantage long-term success procedures implant-supported restorations. is able reduce co-morbidity procedure ameliorating post-operative phase. LLLT an adjuvant protocol improve soft hard tissues response treatment
Язык: Английский
Процитировано
59
International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(6), С. 3690 - 3690
Опубликована: Март 20, 2022
Autogenous tooth graft is an innovative and ingenious technique that employs a stepwise approach utilizes human teeth as autogenous source of bone graft. The structure closely resembles bone, both physically biochemically, can be efficiently used for the process it depicts properties osteoinduction osteoconduction. has characteristics similar to grafts in terms healing potential, physical properties, clinical outcome. shown reasonable promise material regeneration maxillary mandibular defects. finds its principal application sinus ridge augmentations socket preservation before implant placement. Additionally, successfully alveolar cleft patients with limited periodontal overall complication rates reported are comparable other sources. However, although long-term results still underway, recommended grafting option defects cranio-facial region.
Язык: Английский
Процитировано
42
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(48), С. 11405 - 11425
Опубликована: Янв. 1, 2023
In this review, the specific mechanisms of bone formation promotion by Zn-based biomaterials are discussed, and recent developments in their applications tissue engineering summarized.
Язык: Английский
Процитировано
32