Journal of Ethnopharmacology, Год журнала: 2019, Номер 247, С. 112213 - 112213
Опубликована: Сен. 25, 2019
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2021, Номер 12
Опубликована: Апрель 15, 2021
Alzheimer’s disease (AD) and Parkinson’s (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, health problem economic burden caused by also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction biological processes such as cell proliferation, apoptosis metabolism. According to reports, it neurotoxicity mediates survival neurons through different substrates forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), caspase-9. Accumulating evidences indicate some natural products can play a neuroprotective role activating PI3K/AKT pathway, providing an effective resource for discovery potential therapeutic drugs. This article reviews relationship between AKT AD PD, discusses based on treat in recent years, hoping provide guidance reference this field. Further development Chinese herbal medicine is needed these diseases.
Язык: Английский
Процитировано
312
Pharmacological Research, Год журнала: 2020, Номер 161, С. 105263 - 105263
Опубликована: Окт. 27, 2020
Panax ginseng (Meyer) and notoginseng (Burkill), belonging to the family Araliaceae, are used worldwide as medicinal functional herbs. Numerous publications over past decades have revealed that both P. contain important bioactive ingredients such ginsenosides exert multiple pharmacological effects on nervous system immune diseases. However, based traditional Chinese medicine (TCM) theory, their applications clearly differ reinforces vital energy promotes blood circulation. In this article, we review similarities differences between in terms of chemical composition effects. Their comparisons indicate contains more polysaccharides amino acids, while has saponins, volatile oil, polyacetylenes. Regarding effects, exhibits better protective cardiovascular disease, nerve cancer, diabetes mellitus, whereas displays a superior effect cerebrovascular disease. The evidence presented facilitates further research clinical these two herbs, exploration relationship components disease efficacy may be critical next step.
Язык: Английский
Процитировано
255
Acta Biochimica et Biophysica Sinica, Год журнала: 2017, Номер 49(10), С. 853 - 866
Опубликована: Июнь 23, 2017
Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary plaque deposits. shows oxidative stress chronic inflammation. In AD, canonical Wingless-Int (Wnt)/β-catenin pathway downregulated, whereas peroxisome proliferator-activated receptor γ (PPARγ) increased. Downregulation of Wnt/β-catenin, through activation glycogen synthase kinase-3β (GSK-3β) by Aβ, inactivation phosphatidylinositol 3-kinase/Akt signaling involve AD. Cannabidiol (CBD) non-psychotomimetic phytocannabinoid from Cannabis sativa plant. PC12 cells, Aβ-induced tau hyperphosphorylation inhibited CBD. This inhibition associated with downregulation p-GSK-3β, an inhibitor Wnt pathway. CBD may also increase Wnt/β-catenin stimulation PPARγ, Aβ ubiquitination precursor protein. attenuates diminishes mitochondrial dysfunction reactive oxygen species generation. suppresses, pro-inflammatory be potential new candidate for therapy.
Язык: Английский
Процитировано
184
Molecular Neurobiology, Год журнала: 2021, Номер 59(1), С. 354 - 385
Опубликована: Окт. 26, 2021
Язык: Английский
Процитировано
122
Antioxidants, Год журнала: 2023, Номер 12(2), С. 280 - 280
Опубликована: Янв. 27, 2023
Neurological and neurodegenerative diseases, particularly those related to aging, are on the rise, but drug therapies rarely curative. Functional disorders organic degeneration of nervous tissue often have complex causes, in which phenomena oxidative stress, inflammation cytotoxicity intertwined. For these reasons, search for natural substances that can slow down or counteract pathologies has increased rapidly over last two decades. In this paper, studies neuroprotective effects flavonoids (especially most widely used, hesperidin quercetin) animal models depression, neurotoxicity, Alzheimer’s disease (AD) Parkinson’s reviewed. The literature topics amounts a few hundred publications vitro vivo (notably rodents) provides us with very detailed picture action mechanisms targets substances. These include decrease enzymes produce reactive oxygen ferroptosis, inhibition mono-amine oxidases, stimulation Nrf2/ARE system, induction brain-derived neurotrophic factor production and, case AD, prevention amyloid-beta aggregation. neuroinflammatory processes been documented as cytokine formation (mainly TNF-alpha IL-1beta) by microglia astrocytes, modulating number regulatory proteins such Nf-kB NLRP3/inflammasome. Although clinical trials humans still scarce, preclinical allow consider hesperidin, quercetin, other interesting safe dietary molecules be further investigated complementary treatments order prevent diseases moderate their deleterious effects.
Язык: Английский
Процитировано
79
Journal of Ginseng Research, Год журнала: 2018, Номер 42(4), С. 401 - 411
Опубликована: Янв. 12, 2018
Longevity in medicine can be defined as a long life without mental or physical deficits. This prevented by Alzheimer's disease (AD). Current conventional AD treatments only alleviate the symptoms reversing progression. Recent studies demonstrated that Panax ginseng extract improves patients with AD, and two main components of might contribute to amelioration. Ginsenosides show various AD-related neuroprotective effects. Gintonin is newly identified constituent contains lysophosphatidic acids attenuates brain neuropathies. decrease amyloid β-protein (Aβ) formation inhibiting β- γ-secretase activity activating nonamyloidogenic pathway, inhibit acetylcholinesterase Aβ-induced neurotoxicity, production reactive oxygen species neuroinflammatory reactions. Oral administration ginsenosides increases expression levels enzymes involved acetylcholine synthesis alleviates cholinergic deficits models. Similarly, gintonin inhibits neurotoxicity activates pathway reduce Aβ increase choline acetyltransferase through acid receptors. plaque deposits, boosting hippocampal systems neurogenesis, thereby ameliorating learning memory impairments. It also cognitive functions AD. attenuate neuropathology multiple routes. review focuses research demonstrating constituents could candidate an adjuvant for treatment. However, clinical investigations including efficacy tolerability analyses may necessary acceptance combination drugs.
Язык: Английский
Процитировано
132
Biochemical Pharmacology, Год журнала: 2017, Номер 141, С. 143 - 155
Опубликована: Июль 8, 2017
Язык: Английский
Процитировано
124
Phytomedicine, Год журнала: 2018, Номер 50, С. 257 - 284
Опубликована: Сен. 20, 2018
Adaptogens are natural compounds or plant extracts that increase adaptability and survival of organisms under stress. stimulate cellular organismal defense systems by activating intracellular extracellular signaling pathways expression stress-activated proteins neuropeptides. The effects adaptogens on mediators adaptive stress response longevity have been reported, but their stress-protective mechanisms still not fully understood.The aim this study was to identify key molecular adaptogenic plants traditionally used treat aging-related disorders, i.e., Rhodiola rosea, Eleutherococcus senticosus, Withania somnifera, Rhaponticum carthamoides, Bryonia alba.To investigate the underlying adaptogens, we conducted RNA sequencing profile gene alterations in T98G neuroglia cells upon treatment analyzed relevance deregulated genes stress-response using silico pathway analysis software.At least 88 3516 regulated were closely associated with (ASRSPs), including neuronal related corticotropin-releasing hormone, cAMP-mediated, protein kinase A, CREB; involving CXCR4, melatonin, nitric oxide synthase, GP6, Gαs, MAPK, neuroinflammation, neuropathic pain, opioids, renin-angiotensin, AMPK, calcium, synapses; dendritic cell maturation G-coupled receptor-mediated nutrient sensing enteroendocrine cells. All samples tested showed significant encoding neurohormones CRH, GNRH, UCN, G-protein-coupled other transmembrane receptors TLR9, PRLR, CHRNE, GP1BA, PLXNA4, a ligand-dependent nuclear receptor RORA, channels, transcription regulators FOS, FOXO6, SCX, STAT5A, ZFPM2, ZNF396, ZNF467, kinases MAPK10, MAPK13, MERTK, FLT1, PRKCH, ROS1, TTN), phosphatases PTPRD, PTPRR, peptidases, metabolic enzymes, chaperone (HSPA6), proteins, all which modulate numerous life processes, playing roles several canonical involved regulation homeostasis organisms. It is for first time report mechanism actions melatonin alike, activated acting through two membrane MT1 MT2 upregulation ligand-specific plays role intellectual disability, neurological retinopathy, hypertension, dyslipidemia, cancer, common aging. Furthermore, upregulated GNRH1, CHRM4, GPR19, VIPR2, TTN, commonly tested. We conclude an adaptation hormone important homeostasis. presumably worked as eustressors ("stress-vaccines") activate system inducing ASRSPs, then reciprocally protected from damage caused distress. Functional investigation interactive demonstrated ASRSPs stress-induced disorders such chronic inflammation, cardiovascular health, neurodegenerative cognitive impairment, cancer.This has elucidated genome-wide herbal brain culture. These data highlight consistent activation affected many modulation homeostasis, indicating ability modify prevent disorders. Overall, provides comprehensive look at exerts effects.
Язык: Английский
Процитировано
105
Aging and Disease, Год журнала: 2017, Номер 8(6), С. 708 - 708
Опубликована: Янв. 1, 2017
Aging is an irreversible physiological process that affects all humans. Numerous theories have been proposed to regarding the from a Western medicine perspective; however, ancient Chinese practices and increasingly gained attention, particularly ginseng, grass has studied for anti-aging properties of its active constituents. This review seeks analyze current data on ginseng properties. The plant species, characteristics, ingredients will be introduced. main part this focused components with regards their effects prolonging lifespan, regulation multiple organ systems including cardiovascular, nervous, immune, skin, as well anti-oxidant anti-inflammatory molecular mechanisms these elucidated via various studies are summarized further evidence ginseng.
Язык: Английский
Процитировано
100
Biomedicine & Pharmacotherapy, Год журнала: 2018, Номер 103, С. 1602 - 1608
Опубликована: Май 7, 2018
Язык: Английский
Процитировано
100