Cancer Letters, Год журнала: 2023, Номер 567, С. 216261 - 216261
Опубликована: Июнь 9, 2023
Язык: Английский
Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(1)
Опубликована: Янв. 1, 2024
Abstract Purpose This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of these are elucidated, comprehensive information is provided on their potential use Methods Using PubMed database, we searched for keywords, including “tumor”, “cancer”, “natural product”, “phytochemistry”, “plant components”, “MAPK-signaling pathway”. We also screened compounds with well-defined structures targeting have effects. used Kingdraw software Adobe Photoshop to draw compound structural diagrams. Results A total 131 papers were searched, from which 85 selected. These clear treatment mainly related pathway. Examples include eupatilin, carvacrol, oridonin, sophoridine, diosgenin, juglone. components classified as flavonoids, phenols, terpenoids, alkaloids, steroidal saponins, quinones. Conclusions Certain MAPK inhibitors been clinical treatment. However, feedback has not promising because genomic instability, drug resistance, side Natural few effects, good medicinal efficacy, a wide range sources, individual heterogeneity biological activity, capable treating disease multiple targets. characteristics make drugs
Язык: Английский
Процитировано
20
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Янв. 22, 2024
Abstract Cervical cancer is the second leading cause of morbidity and mortality in women worldwide. Traditional treatment methods have become limited. Naringenin, a flavonoid abundant various fruits herbal medicines, has demonstrated anti-tumor properties among other effects. This research undertook to elucidate mechanism naringenin context cervical by leveraging network pharmacology performing experimental validation. Initial steps involved predicting potential targets subsequently screening for overlaps between these those related cancer, followed analysis their interrelationships. Molecular docking was utilized verify binding effect central target. Within framework pharmacology, it discovered that might possess anti-cancer specific cancer. Following this, effects on Hela cell viability, migration, invasion were assessed employing CCK-8, transwell, wound healing assays, western blotting. Experimental data indicated attenuates migration cells via downregulation EGFR/PI3K/AKT signaling pathway. Thus, our findings suggest therapeutic impacts multiple mechanisms, primarily inhibiting through EGFR/PI3K/AKT/mTOR study offers fresh insights future clinical studies.
Язык: Английский
Процитировано
19
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июль 3, 2024
Diabetic cardiomyopathy (DCM) is a myocardial-specific microvascular disease caused by diabetes that affects the structure and function of heart considered to be leading cause morbidity death in patients with diabetes. Currently, there no specific treatment or preventive drug for DCM, an urgent need develop new drugs treat DCM. Traditional Chinese medicine (TCM) has rich experience its characteristics multi-target, multi-pathway, multi-component, few side effects can effectively deal complexity long-term nature Growing evidence suggests myocardial fibrosis, inflammation, oxidative stress, apoptosis, cardiac hypertrophy, advanced glycation end product deposition were main pathologic mechanisms According pathological mechanism this study revealed potential metabolites prescriptions TCM against DCM from perspective signaling pathways. The results showed TGF-β/Smad, NF-κB, PI3K/AKT, Nrf2, AMPK, NLRP3, Wnt/β-catenin pathways key aim was summarize update screen targets candidates provide ideas more experimental clinical use
Язык: Английский
Процитировано
19
Biomolecules, Год журнала: 2023, Номер 13(7), С. 1105 - 1105
Опубликована: Июль 12, 2023
Betulin is a natural triterpene, usually from birch bark, known for its potential wound-healing properties. Despite having wide range of pharmacological targets, no studies have proposed betulin as multitarget compound. has protective effects against cardiovascular and liver diseases, cancer, diabetes, oxidative stress, inflammation. It reduces postprandial hyperglycemia by inhibiting α-amylase α-glucosidase activity, combats tumor cells inducing apoptosis metastatic proteins, modulates chronic inflammation blocking the expression proinflammatory cytokines via modulation NFκB MAPKs pathways. Given to influence diverse biological networks with high target specificity, it can be hypothesized that may eventually become new lead drug development because modify variety targets. The summarized research revealed beneficial in various diseases attributed, at least part, anti-inflammatory activity. This review focuses on sources, pharmacokinetics, activity betulin, multi-target signaling pathways such MAPK, NF-κB, Nrf2, which are important regulators response stress body.
Язык: Английский
Процитировано
39
Redox Report, Год журнала: 2024, Номер 29(1)
Опубликована: Фев. 6, 2024
Jaceosidin (JAC) is a natural flavonoid with anti-oxidant and other pharmacological activities; however, its anti-cancer mechanism remains unclear. We investigated the of action JAC in gastric cancer cells. Cytotoxicity apoptosis assays showed that effectively killed multiple cells induced human adenocarcinoma AGS via mitochondrial pathway. Network analysis suggested activity was linked to reactive oxygen species (ROS), AKT, MAPK signaling pathways. Furthermore, accumulated ROS up-regulate p-JNK, p-p38, IκB-α protein expressions down-regulate p-ERK, p-STAT3, NF-κB expressions. Cell cycle assay results p21 p27 p-AKT, CDK2, CDK4, CDK6, Cyclin D1, E induce G0/G1 phase arrest. migration Wnt-3a, p-GSK-3β, N-cadherin, β-catenin E-cadherin expression inhibit migration. N-acetyl cysteine pre-treatment prevented change these In summary, arrest inhibited through ROS-mediated pathways
Язык: Английский
Процитировано
9
The American Journal of Chinese Medicine, Год журнала: 2024, Номер 52(04), С. 987 - 1011
Опубликована: Янв. 1, 2024
Triple negative breast cancer (TNBC) is an aggressive subtype of cancer. Conventional treatment options for TNBC often have limited efficacy and significant side effects. In recent years, traditional Chinese medicine (TCM) has shown promising results in the TNBC. TCMs include herb combinations that synergistic effects to regulate homeostasis body, reduce tumor resistance, improve patient quality life. At present, three main TCM methods are used treat clinic: strengthening body’s dispelling phlegm, removing toxins. This paper reviews theories mechanisms each treatment. The method resistance emphasizes enhancing original Qi fight against pathogenic factors; phlegm seeks eliminate stagnation alleviate burden on affected organs; toxins focuses detoxification detumescence remove toxic elements associated with Although these from different etiologies, they achieved good therapeutic represent important academic approach: That is, cure disease a comprehensive view body restore balance Yin Yang. knowledge lays foundation future development reasonable application clinic.
Язык: Английский
Процитировано
8
Molecular Carcinogenesis, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
ABSTRACT β‐elemene has a variety of anti‐inflammatory, antioxidant, and antitumor effects. Currently, the influence on adrenocortical carcinoma (ACC) malignant progression action mechanism remains unclear. This research aims to explore ACC progression. The impacts cell viability, proliferation, migration, apoptosis were investigated through CCK‐8 assay, clone formation Transwell experiment, Wound healing flow cytometry. miR‐486‐3p expression was analyzed utilizing RT‐qPCR. According different databases, neuronal pentraxin 1 (NPTX1) is predicted downstream target gene miR‐486‐3p. Western blot RT‐qPCR utilized examine NPTX1 expression. Silencing or Overexpression in cells further explored whether affects by regulating miR‐486‐3p/NPTX1. Finally, subcutaneous graft tumor model constructed investigate how may impact growth vivo. decreased hindered proliferation migration capacity, induced cells. level notably reduced comparison normal cells, but treatment with markedly increased Additionally, showed high NPTX1, while targeted negative regulation NPTX1. whereas overexpression reversed both attenuated suppressive behavior suppressed vivo β‐elemene. In conclusion, reduces hinders induces miR‐486‐3p/NPTX1 axis.
Язык: Английский
Процитировано
1
Phytomedicine, Год журнала: 2022, Номер 99, С. 153986 - 153986
Опубликована: Фев. 11, 2022
Язык: Английский
Процитировано
36
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 158, С. 114104 - 114104
Опубликована: Дек. 12, 2022
Arctium lappa L. is a medicinal edible homologous plant, commonly known as burdock or bardana, which belongs to the Asteraceae family. It widely distributed throughout Northern Asia, Europe, and North America has been utilized for hundreds of years. The roots, fruits, seeds, leaves A. have extensively used in traditional Chinese Medicine (TCM). attracted great deal attention due its possession highly recognized bioactive metabolites with significant therapeutic potential. Numerous pharmacological effects demonstrated vitro vivo by metabolites, including antimicrobial, anti-obesity, antioxidant, anticancer, anti-inflammatory, anti-diabetic, anti-allergic, antiviral, gastroprotective, hepatoprotective, neuroprotective activities. Additionally, considerable clinical efficacies valuable applications nanomedicine. Collectively, this review covers properties ethnopharmacology aspects, effects, trials, field Hence, should be paid trials industrial plant particular emphasis, on drug discovery nanotechnology.
Язык: Английский
Процитировано
35
Frontiers in Pharmacology, Год журнала: 2022, Номер 12
Опубликована: Янв. 25, 2022
Female breast cancer, ovarian cervical and endometrial cancer are the most common tumors causes of cancer-related mortality worldwide in women. Drugs derived from natural plants play important roles malignant tumor therapy. Salvia miltiorrhiza is a commonly used Chinese herb which has been treatment liver diseases cardiovascular because its positive effect promoting blood circulation, increasing oxidative stress, removing stasis. Recently, studies have found that fat-soluble components such as tanshinone II, I, cryptotanshinone, dihydrotanshinone I displayed good antitumor activity vivo vitro for gynecological by different molecular mechanisms. In this study, latest research progress on mechanism compounds was reviewed to provide references clinical application these (tanshinone I).
Язык: Английский
Процитировано
34