Cancer Letters, Год журнала: 2023, Номер 567, С. 216261 - 216261
Опубликована: Июнь 9, 2023
Язык: Английский
Drug Design Development and Therapy, Год журнала: 2021, Номер Volume 15, С. 3863 - 3879
Опубликована: Сен. 1, 2021
Abstract: Cancer is still an insurmountable problem for humans and critically attacking human health. In recent years, natural products have gained increasing attention in the field of anti-tumor due to their extensive sources minimal side effects. Maslinic acid (MA), a pentacyclic triterpene mainly derived from olive tree ( Olea europaea L.) has been confirmed possess great anti-cancer This paper reviewed inhibitory effect MA its derivatives on lung cancer, colon ovarian gastric lymphatic, leukemia, breast pancreatic melanoma, prostate renal cell carcinoma, gallbladder bladder among others. inhibited proliferation various tumor cells showed lower IC 50 values melanoma 518A2 cancer MKN28 compared with other lines. A series semi-synthetic obtained by modifying chemical structure shown high cytotoxicity lines, but low non-malignant cells, which conducive developing potential as chemotherapeutic agent. These studies suggest that broad prospects development antitumor therapeutics future warrant further study. Keywords: maslinic acid, tumor, mechanism,
Язык: Английский
Процитировано
27
Chinese Medicine, Год журнала: 2022, Номер 17(1)
Опубликована: Янв. 6, 2022
The decoction of Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) has been reported as a potential antitumor agent for colorectal cancer (CRC) in experimental clinical studies, but its underlying mechanism is still unclear.The current research aims to explore the (AR decoction) treatment CRC mechanism. SW620 cells were transient transfection overexpress or knock down wnt 5 β-Catenin. -containing serum (AR-CS) was used interfere with cells. Additional AR-CS, Wnt5 inhibitor (IWP-4), β-Catenin (JW55) intervene Furthermore, subcutaneously injection into right flank nude mice replicated xenograft mice, which treated AR 21 days.AR-CS significantly reduced mRNA protein expression levels Wnt5, β-Catenin, ARF6, N-Cadherin cells, while inhibiting proliferation migration In overexpressing these effects AR-CS suppressed. On contrary, inhibitory effect on ARF6 cell enhanced, when knocked suppressed by inhibitors. Moreover, mouse model tumors, not only tumor volume inhibited tumor, also inhibit LRP5, LRP6, TCF-4, LEF1.The histopathology showed increased apoptosis tissues, did cause pathological damage kidney liver.Our results provide evidence that inhibits Wnt5/β-catenin signaling development CRC, promising traditional medicine CRC.
Язык: Английский
Процитировано
21
Oxidative Medicine and Cellular Longevity, Год журнала: 2022, Номер 2022, С. 1 - 14
Опубликована: Июнь 24, 2022
Allicin, an organic sulfur compound extracted from the bulb of Allium sativum, can potentially prevent various tumors. Our previous study found that allicin effectively suppress proliferation osteosarcoma cells. However, molecular mechanisms have not been illustrated. In this study, Saos-2 and U2OS cells were used to investigate underlying mechanisms. A series experiments carried out authenticate anticancer property allicin. Knockdown lncRNA MALAT1 inhibited proliferation, invasion migration promoted apoptosis miR-376a increased invasion, dropped Furthermore, knockdown reversed influences silencing in Based on our data, could downregulate expression miR-376a, subsequently accelerating osteosarcoma. Moreover, oxidative stress autophagy identified as potential key pathway Allicin growth via MALATI-miR-376a. We also promotes inhibit by inhibiting Wnt/β-catenin vivo vitro. All data showed MALATI-miR-376a-Wnt/β-catenin pathway.
Язык: Английский
Процитировано
20
Journal of Ethnopharmacology, Год журнала: 2022, Номер 304, С. 116041 - 116041
Опубликована: Дек. 17, 2022
Язык: Английский
Процитировано
20
Cancer Letters, Год журнала: 2023, Номер 567, С. 216261 - 216261
Опубликована: Июнь 9, 2023
Язык: Английский
Процитировано
11