Clinical efficacy of integrated traditional Chinese and western medicine in the treatment of oligoasthenospermia in male infertility of kidney-yang deficiency type

Journal of Men s Health, Год журнала: 2023, Номер 19(12), С. 99 - 99

Опубликована: Янв. 1, 2023

This study examines the clinically comprehensive effects of Wuzi Shenqi Decoction, an acupoint application that combines traditional Chinese medicine with western on male infertility oligoasthenospermia kidney-yang deficiency type.A total 184 infertiles who came to our hospital from April 2022 June 2023 were randomly assigned a group (n = 92) and experimental 92).The was treated L-carnitine oral solution, while Decoction combined based group.Before after treatment, clinical efficacy, semen parameters (semen volume, sperm density, survival rate, motility), sexual hormone (follicle stimulating (FSH), luteinizing (LH), testosterone (T), prolactin (PRL), estradiol), TCM (Traditional Medicine) syndrome scores observed compared between both groups.Before there no significant difference in parameter index, index score groups (p > 0.05); higher than before diminished < 0.05).The overall response rate 92.39%, which significantly (72.83%) 0.05).For patients type, use plus solution can effectively improve symptoms patients, quality, regulate sex levels, is worthy application.

Язык: Английский

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Aromatic Chemical Constituent of Chimonanthus Nitens Oliv Leaf Profiling by Uhplc-Q/Tof-Ms and Bioactive Material Basis Investigation

SSRN Electronic Journal, Год журнала: 2022, Номер unknown

Опубликована: Янв. 1, 2022

Coumarins and flavonoids are important aromatic natural compounds widely distributed in medicinal plants. Most of them possess diverse bioactivities mainly bioactive material foundation. Chimonanthus nitens Oliv. Leaf(CNOL)is a famous traditional Chinese medicine has potential antiinflammation antivirus effects. Moreover, its patent drug is used for prevention Covid-19 China. A few literatures reported chemical constituents relating to coumarins flavonoids. However, too limited amounts analogues were identified from CNOL understand the basis. In this study, ultra-high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTOF-MS/MS) was utilized global profiling compounds. Fragmentation patterns 12 reference intensely examined establish broken mechanisms. Additionally, calculation chemistry virtual MS 3 experiments also performed rationalize proposal. We found that fragmentation affected by dearomatic process, isolated methoxy or more vicinal substituents onto benzene promotes process greatly. Besides, coumarin glycoside eliminating sugar group via “hydrogenation” reaction referring McLafferty rearrangement firstly founded. Based on constructed routes, total 124 unambiguously tentatively CNOL, including 66 coumarins, 58 Lastly, order explore basis principal component analysis (PCA) orthogonal partial least squares discriminant (OPLS-DA) identify differential markers between methanol extract (prepared ultrasonic extraction) water pharmaceutical technology corresponding drug), 33 as characteristic markers. The will set foundation future research provide theory further study.

Язык: Английский

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The therapeutic potential of cuscuta chinensis lam: A Systematic Review Type of article: Review

International Journal of All Research Education & Scientific Methods, Год журнала: 2022, Номер 10(05)

Опубликована: Янв. 1, 2022

Cuscuta chinensis Lam is an important medicinal plant from convolvulacea family widely available in China, India and other Asian countries. It has been very popular among traditional Chinese medicine for a long time. It's parasitic possessing wide array of folkloric activities like anti-aging, antioxidants, anti-inflammatory, anti-osteoporosis, anticancer, hepatoprotective, etc .from the study done; it suggests that antioxidants antiinflammatory constituents are mainly responsible its pharmacological actions. This review based on literature 2015 to 2021. Data was collected journals, books, internet [Wikipedia, Google scholar, pinned, science direct publications], abstracts full text articles were analyzed compiled. The present data offers primary information future studies chinensis. will be helpful researches / scientists working this get new insight continue further investigation same plant.

Язык: Английский

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Aromatic Chemical Constituent of Chimonanthus Nitens Oliv Leaf Profiling by UHPLC-Q/TOF-MS

SSRN Electronic Journal, Год журнала: 2022, Номер unknown

Опубликована: Янв. 1, 2022

Coumarins and flavonoids are important aromatic natural compounds widely distributed in medicinal plants. Most of them possess diverse bioactivities mainly bioactive material foundation. However, the fragmentation patterns investigation under electrospray ion source mass is still ongoing rapid chemical structure identification by tandem remains to be trapped functional group assignment. Herein, 12 reference were intensely examined establish broken mechanisms. Calculation chemistry virtual MS3 experiments performed rationalize proposed Four main breakouts made during this work. Firstly, we found that reaction for both coumarins was facilitated dearomatic process. Moreover, methoxy tends lose methyl radical which immediately destroys aromaticity accelerates backbone broken. Secondly, coumarin glycoside eliminating sugar via McLafferty rearrangement firstly uncovered, dialogue ions m/z 147.0440, 119.0488 91.0543 established. Thirdly, a series fresh mechanisms proposed, such as shift, H ring expanding reaction, intramolecular condensation. Finally, characteristic diagnostic at 145.0495, 127.0390, 85.0284 taken characterization flavonoid with six-carbon pyranose. The constructed routes, novel gas phase combined utilized constituent profiling Chimonanthus nitens Oliv. Leaf(CNOL), famous traditional Chinese medicine has potential antiinflammation antivirus effects. its patent drug used prevention Covid-19 China. Lastly, total 124 unambiguously or tentatively identified CNOL, those 95 discovered CNOL 41 new compounds. constituents will set foundation future basis research.

Язык: Английский

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Jujing Zhuyu decoction inhibits apoptosis in rats with asthenozoospermia by regulating the mitochondrial apoptosis pathway

Andrologia, Год журнала: 2022, Номер 54(11)

Опубликована: Ноя. 15, 2022

Jujing Zhuyu decoction (JZD) is a traditional Chinese medicine that effectively improves sperm motility. However, the molecular mechanism of JZD on asthenozoospermia still remains unknown. In this study, we investigated effect mitochondrial apoptosis pathway in an rat model. Sixty Sprague-Dawley rats were randomly divided into five groups-control, tripterygium glycosides (GTW) model, JZD-low (JZD-L), JZD-medium (JZD-M), and JZD-high (JZD-H) groups (n = 12/group). GTW was used to generate The JZD-L, JZD-M, JZD-H administered 5, 10, or 15 g kg-1 day-1 granules respectively, for 4 weeks. Testicular tissue morphology examined using histological staining, while count determined manual computer-aided semen analyses. Apoptosis spermatogenic cells detected with TUNEL assay, expression proteins genes related western blotting quantitative reverse transcription-polymerase chain reaction respectively. Histomorphological evaluation revealed superior seminiferous tubule structure arrangement as well improved cell compared those model group. Moreover, quality apoptotic index significantly Additionally, mRNA protein abundance Apaf-1, Bax, Cyto-c, caspase-3 reduced, Bcl-2 increased all reduces rate promotes survival by regulating pathway. This provides experimental support treatment JZD.

Язык: Английский

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