International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 27 - 27
Опубликована: Дек. 24, 2024
The
inflammatory
response
consists
of
two
stages:
priming
and
triggering.
triggering
stage
is
marked
by
the
activation
inflammasomes,
which
are
cytosolic
protein
complexes
acting
as
platforms
for
inflammation.
Inflammasomes
divided
into
canonical
noncanonical
categories.
Inflammatory
lung
diseases
such
asthma,
chronic
obstructive
pulmonary
disease
(COPD),
acute
respiratory
distress
syndrome
(ARDS),
injury,
fibrosis
arise
from
inflammation
damage.
While
role
inflammasomes
in
these
well
demonstrated,
recent
findings
emphasize
critical
roles
regulating
various
conditions.
Particularly,
new
studies
highlight
their
involvement
diseases.
This
review
delves
research
on
regulatory
human
caspase-4
murine
caspase-11,
development
diseases,
potential
targeting
treatments.
Archives of Pharmacology and Therapeutics,
Год журнала:
2023,
Номер
5(1), С. 53 - 66
Опубликована: Ноя. 4, 2023
Helicobacter
pylori
(H.
pylori)
infection
is
a
major
global
health
concern,
with
an
estimated
50%
of
the
world's
population
infected.
The
bacterium
colonizes
stomach
and
associated
range
gastrointestinal
diseases,
including
chronic
gastritis,
peptic
ulcers,
gastric
cancer.
current
standard
care
for
H.
involves
combination
antibiotics
proton
pump
inhibitors
(PPIs),
but
widespread
use
has
led
to
development
antibiotic-resistant
strains
pylori,
making
treatment
more
difficult.
Recent
advances
in
diagnostic
strategies
include
non-invasive
tests
serological
biomarkers.
While
PPIs
remains
primary
approach,
there
growing
interest
alternative
therapies,
botanical
extracts,
natural
products,
traditional
medicines.
research
also
explored
potential
probiotics,
phage
therapy,
novel
antibiotics,
such
as
rifabutin
furazolidone,
infection.
studies
have
artificial
intelligence
(AI)
diagnosis
management
AI-assisted
screening
methods
identified
extracts
products
anti-H.
activity,
providing
new
avenues
therapeutic
development.
Additionally,
AI
can
improve
accuracy
outcomes.
Although
these
approaches
show
promise,
further
needed
confirm
their
efficacy,
safety,
optimal
dosing.
Novel
therapies
therapy
may
provide
treatments
help
overcome
antimicrobial
resistance.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2091 - 2091
Опубликована: Фев. 8, 2024
Inflammasomes
are
intracellular
multiprotein
complexes
that
activate
inflammatory
signaling
pathways.
comprise
two
major
classes:
canonical
inflammasomes,
which
were
discovered
first
and
activated
in
response
to
a
variety
of
pathogen-associated
molecular
patterns
(PAMPs)
danger-associated
(DAMPs),
non-canonical
recently
only
lipopolysaccharide
(LPS).
Although
larger
number
studies
have
successfully
demonstrated
particularly
the
NLRP3
inflammasome,
play
roles
various
rheumatic
diseases,
including
rheumatoid
arthritis
(RA),
infectious
(IR),
gouty
(GA),
osteoarthritis
(OA),
systemic
lupus
erythematosus
(SLE),
psoriatic
(PA),
ankylosing
spondylitis
(AS),
Sjögren’s
syndrome
(SjS),
regulatory
such
as
mouse
caspase-11
human
caspase-4
these
diseases
still
largely
unknown.
Interestingly,
an
increasing
reported
possible
for
inflammasomes
pathogenesis
models
disease.
This
review
comprehensively
summarizes
discusses
recent
emerging
demonstrating
focusing
on
progression
types
provides
new
insights
into
strategies
developing
potential
therapeutics
prevent
treat
well
associated
by
targeting
inflammasomes.
Current Topics in Medicinal Chemistry,
Год журнала:
2023,
Номер
24(4), С. 301 - 342
Опубликована: Сен. 15, 2023
Abstract:
Biologically
active
secondary
metabolites,
essential
oils,
and
volatile
compounds
derived
from
medicinal
aromatic
plants
play
a
crucial
role
in
promoting
human
health.
Within
the
large
family
Asteraceae,
genus
Artemisia
consists
of
approximately
500
species.
species
have
rich
history
traditional
medicine
worldwide,
offering
remedies
for
wide
range
ailments,
such
as
malaria,
jaundice,
toothache,
gastrointestinal
problems,
wounds,
inflammatory
diseases,
diarrhoea,
menstrual
pains,
skin
disorders,
headache,
intestinal
parasites.
The
therapeutic
potential
is
multitude
phytoconstituents,
including
terpenoids,
phenols,
flavonoids,
coumarins,
sesquiterpene
lactones,
lignans,
alkaloids
that
serve
pharmaceutical
ingredients
(API).
remarkable
antimalarial,
antimicrobial,
anthelmintic,
antidiabetic,
anti-inflammatory,
anticancer,
antispasmodic,
antioxidative
insecticidal
properties
possessed
by
are
attributed
to
these
APIs.
Interestingly,
several
commercially
utilized
drugs,
arglabin,
artemisinin,
artemether,
artesunate,
santonin,
tarralin
also
been
different
However,
despite
vast
potential,
only
limited
number
exploited
commercially.
Further,
available
literature
on
pharmacological
uses
lacks
comprehensive
reviews.
Therefore,
there
an
urgent
need
bridge
existing
knowledge
gaps
provide
scientific
foundation
future
research
endeavours.
It
this
context,
present
review
aims
account
uses,
phytochemistry,
documented
biological
toxicity
all
offers
useful
insights
practitioners
researchers
into
underutilized
their
applications.
This
stimulate
further
exploration,
experimentation
collaboration
fully
realize
augmenting
health
well-being.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(12), С. 10402 - 10402
Опубликована: Июнь 20, 2023
Inflammasomes
are
multiprotein
complexes
that
activate
inflammatory
responses
by
inducing
pyroptosis
and
secretion
of
pro-inflammatory
cytokines.
Along
with
many
previous
studies
on
diseases
induced
canonical
inflammasomes,
an
increasing
number
have
demonstrated
non-canonical
such
as
mouse
caspase-11
human
caspase-4
emerging
key
players
in
various
diseases.
Flavonoids
natural
bioactive
compounds
found
plants,
fruits,
vegetables,
teas
pharmacological
properties
a
wide
range
Many
successfully
flavonoids
play
anti-inflammatory
role
ameliorate
inhibiting
inflammasomes.
Others
the
roles
diseases,
new
mechanism
which
inhibit
This
review
discusses
recent
investigated
inflammasomes
further
provides
insight
into
developing
flavonoid-based
therapeutics
potential
nutraceuticals
against
