Liver diseases: epidemiology, causes, trends and predictions

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 4, 2025

Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.

Язык: Английский

---

Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1

Bio-Design and Manufacturing, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

---

Polygonatum kingianum Polysaccharides Enhance the Preventive Efficacy of Heat-Inactivated Limosilactobacillus reuteri WX-94 against High-Fat-High-Sucrose-Induced Liver Injury and Gut Dysbacteriosis

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(17), С. 9880 - 9892

Опубликована: Апрель 22, 2024

Limosilactobacillus reuteri (L. reuteri) is an efficacious probiotic that could reduce inflammation and prevent metabolic disorders. Here, we innovatively found Polygonatum kingianum polysaccharides (PKP) promoted proliferation increased stability of L. WX-94 (a strain showing anti-inflammation potentials) in simulated digestive fluids vitro. PKP was composed galactose, glucose, mannose, arabinose. The cell-free supernatant extracted from cultured with ABTS•+, DPPH•, FRAP scavenging capacities compared the medium without metabolites health-promoting activities, e.g., 3-phenyllactic acid, indole-3-lactic indole-3-carbinol, propionic acid. Moreover, enhanced alleviating effects heat-inactivated on high-fat-high-sucrose-induced liver injury rats via reducing regulating expressions protein genes involved fatty acid metabolism (such as HIF1-α, FAβO, CPT1, AMPK) profiles liver. Such benefits correlated its prominent enriching Lactobacillus short-chain acids while Dubosiella, Fusicatenilacter, Helicobacter, Oscillospira. Our work provides novel insights into property emphasizes great potential inactivated contracting unhealthy diet-induced dysfunctions gut dysbacteriosis.

Язык: Английский

---

Fanlian Huazhuo Formula alleviates high-fat diet-induced non-alcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(30), С. 3584 - 3608

Опубликована: Авг. 8, 2024

Fanlian Huazhuo Formula (FLHZF) has the functions of invigorating spleen and resolving phlegm, clearing heat purging turbidity. It been identified to have therapeutic effects on type 2 diabetes mellitus (T2DM) in clinical application. Non-alcoholic fatty liver disease (NAFLD) is frequently diagnosed patients with T2DM. However, potential FLHZF NAFLD underlying mechanisms need further investigation.

Язык: Английский

---

Hydroxy-α-sanshool from the fruits of Zanthoxylum bungeanum Maxim. promotes browning of white fat by activating TRPV1 to induce PPAR-γ deacetylation

Phytomedicine, Год журнала: 2023, Номер 121, С. 155113 - 155113

Опубликована: Сен. 21, 2023

Язык: Английский

---

Development and optimization of the Glabridin-loaded dissolving microneedle for enhanced treatment of keloid

International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100267 - 100267

Опубликована: Июль 1, 2024

Glabridin (Gla) has been reported to have significant effects in scar treatment, and however, the water insolubility of Gla leads its poor transdermal absorption ability, which affects bioactivities. Therefore, we attempted prepare dissolving microneedles (Gla-MN) improve absorbtion Gla. After investigation 3 factors including needle tip matrix concentration, prescription concentration backing material, dissolution method Gla, finally determined process parameters 10% hyaluronic acid (HA) as 5% polyvinyl alcohol (PVA) backing, according Gla-MN was prepared with good characteristics high hardness, complete appearance vitro ability. We then loaded onto measured that average drug loading 2.26 ± 0.11 μg/mg cumulative release up 76.9% after 24 h. In addition, had skin penetration properties, penetrating at least 4 5 layers parafilm. And basically could return normal h piercing. Importantly, our results showed higher delivery therapeutic against keloid than same dosage.

Язык: Английский

---

Modulatory effects of traditional Chinese medicines on gut microbiota and the microbiota-gut-x axis

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 9, 2024

The gut microbiota offers numerous benefits to the human body, including promotion of nutrient absorption, participation in metabolic processes, and enhancement immune function. Recent studies have introduced concept gut-organ axis, which encompasses interactions such as gut-brain gut-liver gut-lung axis. This underscores complex interplay between various organs tissues, brain, heart, lungs, liver, kidneys, muscles, bones. Growing evidence indicates that can influence onset progression multi-organ system diseases through their effects on Traditional Chinese medicine has demonstrated significant efficacy regulating gastrointestinal system, leveraging its unique advantages. Considerable advancements been made understanding role axis within mechanisms action traditional medicine. review aims elucidate roles health, explore potential connections microbiota, examine therapeutic microbiota-gut-organ Furthermore, addresses limitations challenges present current research while proposing directions for future investigations this area.

Язык: Английский

---

Advances in research on metabolic dysfunction-associated steatotic liver disease

Life Sciences, Год журнала: 2025, Номер 362, С. 123362 - 123362

Опубликована: Янв. 4, 2025

Язык: Английский

---

Lactobacillus rhamnosus GG Ameliorates Atherosclerosis via Suppression of Oxidative Stress and Inflammation by Reshaping the Gut Microbiota

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 751, С. 151417 - 151417

Опубликована: Фев. 5, 2025

Язык: Английский

---

Eleutheroside B Ameliorates Cardiomyocytes Necroptosis in High-Altitude-Induced Myocardial Injury via Nrf2/HO-1 Signaling Pathway

Antioxidants, Год журнала: 2025, Номер 14(2), С. 190 - 190

Опубликована: Фев. 7, 2025

This study was designed to evaluate the protective effects of eleutheroside B (EB) in high-altitude-induced myocardial injury (HAMI) and unravel underlying molecular mechanisms. SD rats were used for vivo experiments. Following pretreatment with EB, exposed a hypobaric environment within chamber 48 h. Electrocardiograms, H&E staining, serum biochemical indices measured EB on HAMI. Immunofluorescence Western blotting utilized detect expression associated proteins. In parallel, hypoxic cell incubator establish an vitro model hypoxia-induced injury. The anti-necroptotic effect its potential mechanisms investigated verified vitro. Exposure hypoxia led electrocardiogram disorders, pathological changes tissue, increased concentrations BNP CK-MB, elevated levels oxidative stress indicators inflammatory factors. Additionally, necroptosis-related proteins upregulated. Pretreatment effectively ameliorated caused by hypoxia, mitigated inflammation, suppressed necroptosis. Furthermore, facilitated translocation Nrf2 into nucleus. conclusion, this provides evidence suggesting that may exert against HAMI inhibiting cardiomyocyte necroptosis via Nrf2/HO-1 signaling pathway.

Язык: Английский

---