Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
15(4), С. 101146 - 101146
Опубликована: Ноя. 14, 2024
Neurodegenerative
disorders
(NDDs)
are
prevalent
chronic
conditions
characterized
by
progressive
synaptic
loss
and
pathological
protein
alterations.
Increasing
evidence
suggested
that
mitochondrial
quality
control
(MQC)
serves
as
the
key
cellular
process
responsible
for
clearing
misfolded
proteins
impaired
mitochondria.
Herein,
we
provided
a
comprehensive
analysis
of
mechanisms
through
which
MQC
mediates
onset
progression
NDDs,
emphasizing
dynamic
stability,
clearance
damaged
mitochondria,
generation
new
In
addition,
traditional
Chinese
medicines
(TCMs)
their
active
monomers
targeting
in
NDD
treatment
have
been
demonstrated.
Consequently,
compiled
TCMs
show
great
potential
NDDs
MQC,
aiming
to
offer
novel
insights
scientific
foundation
use
stabilizers
prevention
treatment.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 24, 2025
Atherosclerosis
(AS)-related
cardiovascular
disease
and
depression
are
often
comorbid,
with
patients
facing
an
increased
risk
of
depression,
which
worsens
AS.
Both
diseases
characterized
by
oxidative
stress
lipid
metabolism
disorders.
Ferroptosis,
a
form
cell
death
iron
overload
harmful
peroxide
accumulation,
is
found
in
various
diseases,
including
AS
depression.
Consistent
the
deposition
peroxidation
(LPO)
that
characterize
ferroptosis
mechanism,
disturbances
also
crucial
pathogenic
mechanisms
The
comorbid
complex,
posing
challenges
for
clinical
treatment.
Chinese
herbs
hold
significant
potential
owing
to
their
multi-target
pharmacological
effects.
Therefore,
this
review
aims
investigate
overload,
LPO,
across
types,
shared
pathogenesis
ferroptosis,
research
on
herbal
medicine
targeting
treatment
anti-AS
co-depression.
This
provides
comprehensive
understanding
co-depression
from
perspective
ferroptosis.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 22, 2025
Alzheimer's
disease
(AD)
is
a
chronic
neurodegenerative
of
the
central
nervous
system
caused
by
loss
neuronal
or
myelin
function,
accompanied
ferroptosis.
Astragalus
membranaceus
(Fisch.)
Bge.
(A.
membranaceus)
one
China's
homologous
lists
medicines
and
food,
its
active
component
saponins
have
neuroprotective
effects.
This
study
examines
mechanism
from
A.
(AS)
in
treating
AD.
UPLC-Q-TOF-MS
analyzed
composition
AS.
Ferroptosis
models
were
established
to
evaluate
anti-AD
efficacy.
As
result,
AS
treatment
inhibited
ferroptosis
SAMP8
mice
restoring
iron
homeostasis
lipid
peroxidation
(LPO)
balance
brain,
thereby
improving
cognitive
impairment
pathological
damage.
Mechanistically,
reduced
Fe2+,
MDA,
ROS
levels
enhanced
protein
SLC7A11,
GPX4,
FTH1,
FPN1.
NADPH
oxidase
4
(NOX4)
overexpression
revealed
that
NOX4,
reducing
NOX4
stability
regulating
NOX4/Nrf2
pathway
erastin-injured
HT22
cells
significantly
alleviating
Therefore,
improved
AD
rebuilding
LPO
brain.
has
potential
be
promising
candidate
medicine
for
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Background
Depression
is
a
complex
psychiatric
disorder
with
limited
therapeutic
options
and
various
side
effects.
Calycosin,
bioactive
compound
derived
from
Astragalus
membranaceus
,
possesses
multiple
pharmacological
properties.
This
study
aimed
to
investigate
the
antidepressant
effects
of
calycosin
in
chronic
mild
stress
(CMS)
animal
models
depression
elucidate
its
underlying
mechanisms.
Methods
The
were
assessed
vivo
using
CMS
depression,
including
grooming
frequency
test,
sucrose
intake
tail
suspension
open
field
test.
Neurogenic
evaluated
by
measuring
levels
BDNF,
GDNF,
NGF
isolated
hippocampus
tissues.
hepatoprotective
liver
enzyme
levels.
molecular
mechanisms
calycosin's
explored
vitro
PC12
cells.
Results
Calycosin
exhibited
potent
antidepressant‐like
activities
depression.
Treatment
significantly
alleviated
depressive
symptoms
improved
neurogenic
Additionally,
displayed
modulating
enzymes
vitro.
are
mediated
stimulation
TrkB–MEK–Erk1/2–CREB
signaling
pathway.
Conclusion
In
conclusion,
shows
promise
as
novel
agent
for
due
diverse
Further
studies
warranted
exact
targets
assess
efficacy
safety
clinical
settings.
