Design and Synthesis of Ester Linked 1,2,3‐Triazole Quinoline Derivatives with Pancreatic β Cells Protective Activity against Oxidative Stress and Endoplasmic Reticulum Stress for Better Management of Type II Diabetes Mellitus DOI

Neeta Kulkarni,

Abhijit Chavan, Pravin C. Mhaske

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(41)

Опубликована: Окт. 28, 2024

Abstract Unresolved endoplasmic reticulum (ER) stress and oxidative lead to the pathogenesis of type II diabetes mellitus (DM). Connecting links between ER pathways might play an important role in treatment diabetes. Here, we used network pharmacology approach find target proteins linking pathways. CHOP emerged as a hub protein from our results was targeted by 16 newly designed synthesized ester linked 1,2,3‐triazole quinoline derivatives molecular docking. Drug likeliness prediction studies revealed all compounds good druggable candidates. Compounds 5b (R = H, R 1 F), 5j CH 3 , 5m OCH H), 5n F) were found have considerable binding energies active site amino acid interactions with CHOP. We further showed that exhibited low toxicity more than 50% cell survival IC50 values. These therefore subjected evaluate their effects on stress. Finally, compound alleviate is also antioxidant. Identification such targets effective improving may provide new insights development therapies management T2DM.

Язык: Английский

Chronic Inflammation Linking Atherosclerosis to Cognitive Impairment: Multi-Target Mechanisms and Therapeutic Advances in Chinese Herbal Medicine DOI Creative Commons

Rumin Huang,

Xiangrui Zhang, Min Ni

и другие.

Brain Behavior and Immunity Integrative, Год журнала: 2025, Номер unknown, С. 100122 - 100122

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Design and Synthesis of Ester Linked 1,2,3‐Triazole Quinoline Derivatives with Pancreatic β Cells Protective Activity against Oxidative Stress and Endoplasmic Reticulum Stress for Better Management of Type II Diabetes Mellitus DOI

Neeta Kulkarni,

Abhijit Chavan, Pravin C. Mhaske

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(41)

Опубликована: Окт. 28, 2024

Abstract Unresolved endoplasmic reticulum (ER) stress and oxidative lead to the pathogenesis of type II diabetes mellitus (DM). Connecting links between ER pathways might play an important role in treatment diabetes. Here, we used network pharmacology approach find target proteins linking pathways. CHOP emerged as a hub protein from our results was targeted by 16 newly designed synthesized ester linked 1,2,3‐triazole quinoline derivatives molecular docking. Drug likeliness prediction studies revealed all compounds good druggable candidates. Compounds 5b (R = H, R 1 F), 5j CH 3 , 5m OCH H), 5n F) were found have considerable binding energies active site amino acid interactions with CHOP. We further showed that exhibited low toxicity more than 50% cell survival IC50 values. These therefore subjected evaluate their effects on stress. Finally, compound alleviate is also antioxidant. Identification such targets effective improving may provide new insights development therapies management T2DM.

Язык: Английский

Процитировано

0