A review on Angelica sinensis alleviates acute lung tissue injury through TLR-4/MyD88 signal pathway DOI Creative Commons
Ke Xu, Xiang Yu,

Shangping Fang

и другие.

Perioperative Precision Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Angelica sinensis (AS), commonly known as Danggui and hailed a premier medicinal herb, holds prominent place in traditional Chinese medicine due to its potent healing properties. It is widely used boost blood vital energy, promote flow, relieve stasis, regulate menstruation, alleviate pain. With advances medical technology, modern interest has surged, spurring more in-depth research into pharmacological mechanisms. This review introduces the principal components of AS therapeutic efficacy, while also summarizing current on fundamental mechanisms involving key inflammatory signal pathways, notably nuclear factor κB mitogen-activated protein kinase. Z-Ligustilide, AS’s primary bioactive compound, exhibits range effects, including anti-inflammatory, anticancer, neuroprotective, anti-apoptotic, organ-protective, antioxidant, analgesic In addition discuss advancements treatment acute lung injury (ALI), this provides detailed exploration main for mitigating ALI induced by lipopolysaccharides, with aim providing theoretical basis inspiration development drugs medicine, representative example. manuscript offers novel method clinical management ALI, thereby presenting additional alternatives intervention.

Язык: Английский

Tocilizumab alleviated lipopolysaccharide-induced acute lung injury by improving PI3K/AKT pathway DOI
Junting Weng,

Shuoyun Weng,

Jing Xu

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

1
Molecular Mechanisms of Ligusticum wallichii and Its Components in Attenuating Acute Cerebral Vasospasm DOI Creative Commons
Bowen Wu, Peiyu Yan,

Mi-Shan Wu

и другие.

World Journal of Traditional Chinese Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Abstract Objective: Acute cerebral vasospasm (aCVS) is a severe complication commonly occurring after subarachnoid hemorrhage, leading to significant morbidity and mortality despite current therapeutic interventions. This study aims elucidate the potential mechanisms of Ligusticum wallichii against aCVS through an integrated approach bioinformatics, meta-analysis, network pharmacology. Materials Methods: Studies related L . were systematically retrieved from public databases, followed by meta-analysis on effectiveness extracts in treating or preventing aCVS. Major components identified Traditional Chinese Medicine (TCM) Systems Pharmacology database, with their three-dimensional structures obtained PubChem. Target predictions human proteins performed using PharmMapper, these complemented ribonucleic acid sequencing differentially expressed genes (DEGs) analysis dataset GSE37924. An intersection was explore overlap between predicted targets. Protein–protein interaction, Gene Ontology, Kyoto Encyclopedia Genes Genomes enrichment analyses conducted, construction pharmacological Cytoscape. The key targets further analyzed validated molecular docking simulations. Results: revealed that tetramethylpyrazine, component extracts, showed alleviating symptoms Key components, such as beta-sitosterol, folic acid, mandenol, myricanone, perlolyrine, senkyunone, wallichilide, linked 414 target proteins. From GSE37924 dataset, 22 candidate identified, perlolyrine playing central roles network, potentially targeting Adenosylmethionine Decarboxylase 1, Adenosine diphosphate-ribosylation factor Casein Kinase 1 Gamma 2, among others, mitigate Conclusions: its demonstrate effects These findings provide scientific support for application treatment, demonstrating direct value TCM modern medical applications.

Язык: Английский

Процитировано

0
Deciphering the Mechanism of Sang Ju Yin in Ameliorating Acute Lung Injury: An Integrated Systems Pharmacology Approach Encompassing Chemical Composition Analysis, Network Pharmacology, Metabolomics, Molecular Docking and Molecular Biology DOI Creative Commons

Ruinan Ren,

Fang Wang, Guiping Zhao

и другие.

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Год журнала: 2025, Номер unknown, С. 100527 - 100527

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Preparation, quality evaluation and preliminary pharmacokinetic-pharmacodynamic studies of synephrine dry powder inhaler DOI Creative Commons

Jiming Ke,

S.R. Li,

Miaomiao Zi

и другие.

Drug Delivery, Год журнала: 2025, Номер 32(1)

Опубликована: Апрель 7, 2025

Acute lung injury (ALI) is a disease characterized by pulmonary edema caused an excessive inflammatory response within the lungs and disruption of alveolar capillary barrier, with high morbidity mortality rate in critically ill patients. Dry powder inhalers (DPI) are effective way administering medication to improve efficacy, inhalation administration not only improves efficacy but also increases bioavailability drug. Synephrine, natural ingredient derived from fruit citrus plant Brassicaceae family, has anti-inflammatory antioxidant properties. In present study, we prepared synephrine dry inhaler (SYN-DPI) anti-solvent precipitation method evaluated it vivo vitro. The vitro results show that SYN-DPI low hygroscopicity good aerodynamic showed had toxicity possessed capacity, which could significantly reduce inflammation, oxidative stress, injury. Pharmacokinetic increased SYN bioavailability. conclusion, this study provides as inhalable formulation can be used ALI.

Язык: Английский

Процитировано

0
Unveiling the gastroprotective effect of the ethyl acetate fraction of Cordia africana Lam. roots against ethanol-induced gastric ulcer and Helicobacter pylori DOI
Engy Mohsen,

Ahlam M. El Fishawy,

Abeer Salama

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер 348, С. 119841 - 119841

Опубликована: Апрель 18, 2025

Язык: Английский

Процитировано

0
Effectiveness and safety of Chinese herbal footbaths as an adjuvant therapy for dysmenorrhea: a systematic review and meta-analysis DOI Creative Commons

Xiaoping Tian,

Jingwen Wei,

Yijia Zhuang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Авг. 5, 2024

To evaluate the effectiveness and safety of Chinese herbal footbaths (CHF) as an adjunctive therapy in managing dysmenorrhea.

Язык: Английский

Процитировано

1
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome DOI
Qing Yao,

Jincai Wen,

Simin Chen

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 336, С. 118661 - 118661

Опубликована: Авг. 17, 2024

Язык: Английский

Процитировано

1
Rapid screening and isolation of potential xanthine oxidase inhibitors in Ganoderma lucidum DOI Creative Commons

Wanchao Hou,

Xu Zhou, Siyuan Zhuang

и другие.

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(9), С. 105925 - 105925

Опубликована: Июль 22, 2024

Given the abundance and intricate nature of chemical components found in natural food ingredients, functional research has long grappled with two significant technical challenges: rapid precise screening active substances targeted preparation. To enhance efficiency fungal preparation, novel methodologies for production xanthine oxidase inhibitors from G. lucidum have been developed. The were rapidly screened using AUF-LC-MS. Molecular docking molecular dynamics simulation used to verify anti-gout activity compounds. Subsequently, as guide, HSCCC SPLC employed separate ingredients. Simultaneously, mechanism action was analyzed by enzymatic reaction kinetics. Finally, verified network pharmacology, its discussed. Four potential inhibitors, namely ganoderic acid C2, B, A, D2, lucidum. Their binding energies −6.29, −6.65, −4.29, −5.96 kcal/mol, respectively. purity four triterpenoid ingredients isolated more than 90 %. These showed a reversible inhibitory effect on oxidase. Network pharmacological studies revealed 71 common targets gout, obtained intersecting targets, identified main metabolic pathways. results indicate that extract can be prevention treatment gout disease. We compounds preparation incorporating enzyme inhibition assays computerized virtual compound chromatography. With this approach, we seamlessly incorporate fast discovery, screening, focused well delving into mechanisms monomers proteases, molecular-level interactions between proteases. This study providing opportunities discover develop new therapeutics health resources.

Язык: Английский

Процитировано

0
Effects of Rhaponticum carthamoides (Willd.) Iljin on endothelial dysfunction and the inflammatory response in type 2 diabetes mellitus mice DOI

Guanjun Nan,

Bo Wang,

Xiaohan Lv

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156134 - 156134

Опубликована: Окт. 10, 2024

Язык: Английский

Процитировано

0
A review on Angelica sinensis alleviates acute lung tissue injury through TLR-4/MyD88 signal pathway DOI Creative Commons
Ke Xu, Xiang Yu,

Shangping Fang

и другие.

Perioperative Precision Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Angelica sinensis (AS), commonly known as Danggui and hailed a premier medicinal herb, holds prominent place in traditional Chinese medicine due to its potent healing properties. It is widely used boost blood vital energy, promote flow, relieve stasis, regulate menstruation, alleviate pain. With advances medical technology, modern interest has surged, spurring more in-depth research into pharmacological mechanisms. This review introduces the principal components of AS therapeutic efficacy, while also summarizing current on fundamental mechanisms involving key inflammatory signal pathways, notably nuclear factor κB mitogen-activated protein kinase. Z-Ligustilide, AS’s primary bioactive compound, exhibits range effects, including anti-inflammatory, anticancer, neuroprotective, anti-apoptotic, organ-protective, antioxidant, analgesic In addition discuss advancements treatment acute lung injury (ALI), this provides detailed exploration main for mitigating ALI induced by lipopolysaccharides, with aim providing theoretical basis inspiration development drugs medicine, representative example. manuscript offers novel method clinical management ALI, thereby presenting additional alternatives intervention.

Язык: Английский

Процитировано

0