Antitumor components and mechanisms of Zanthoxylum bungeanum Maxim with medicine and food homology
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 28, 2025
Zanthoxylum
bungeanum
Maxim
(
Z.
)
is
a
medicinal
and
edible
plant
commonly
used
to
improve
the
flavor
of
Chinese
cuisine
due
its
unique
numbing
taste.
It
recognized
for
properties,
including
bodywarming,
relieving
cold,
promoting
blood
circulation,
alleviating
pain.
Additionally,
has
been
extensively
studied
antitumor
properties.
In
this
study,
various
scientific
databases
network
pharmacology
were
search
information
about
components
treatment
tumors.
Numerous
active
have
identified,
demonstrating
We
discovered
that
can
modulate
multiple
signaling
pathways
across
targets
using
pharmacological
predictions,
highlighting
strong
potential.
The
traditional
medicine
compound
containing
promote
apoptosis,
arrest
cell
cycle,
inhibit
invasion
metastasis,
autophagy,
increase
sensitivity
chemotherapeutic
drugs
through
P53,
PI3K/AKT,
Wnt/β-catenin
other
pathways,
which
are
effective
against
cancers,
hepatocellular
cancer,
gastric
breast
cancer.
extracts
demonstrated
promising
effects
tumors,
indicating
their
potential
use
in
future
cancer
therapies
offering
new
strategies
tumor
treatment.
However,
clinical
studies
evaluating
efficacy
toxicity
humans
scarce.
Therefore,
well-designed
trials
should
be
prioritized
establish
solid
foundation
Язык: Английский
Phytochemical profile, nutritional composition, and antioxidant activities of Exallage auricularia and Trichosanthes costata: A comparative study
Food and Humanity,
Год журнала:
2025,
Номер
unknown, С. 100559 - 100559
Опубликована: Март 1, 2025
Язык: Английский
Potential anti-nociceptive effect of beta-ionone on orofacial pain through GABA and glycine mimetic action on substantia gelatinosa neurons of trigeminal subnucleus caudalis in mice
Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Mechanisms and multimodal treatment of neuropathic pain associated with degenerative cervical spondylosis: Current status and progress.
PubMed,
Год журнала:
2024,
Номер
49(11), С. 1840 - 1848
Опубликована: Ноя. 28, 2024
Degenerative
cervical
spondylosis
is
a
common
spinal
disorder
in
the
elderly.
During
its
progression,
structural
changes
such
as
intervertebral
disc
degeneration,
vertebral
osteophyte
formation,
and
facet
joint
degeneration
directly
impact
neural
structures,
resulting
neuropathic
pain.
Moreover,
release
of
inflammatory
mediators
can
further
exacerbate
pain,
increased
neuronal
excitability
considered
one
key
pathological
mechanisms
Current
diagnostic
assessment
methods
for
pain
associated
with
degenerative
include
clinical
evaluation,
imaging
techniques
(such
X-ray,
computed
tomography,
magnetic
resonance
imaging),
neurophysiological
examinations
(including
electromyography
nerve
conduction
studies).
Treatment
options
primarily
involve
pharmacological
therapy,
physical
surgical
intervention,
which
have
shown
promising
short-term
outcomes.
Despite
progress
made
through
combined
use
various
treatment
modalities,
their
long-term
efficacy
safety
remain
to
be
investigated.
Personalized
multimodal
strategies
are
essential
improving
patients'
quality
life.
Future
research
should
continue
explore
develop
innovative
therapeutic
optimize
management.
Язык: Английский