Bile acids as a key target: traditional Chinese medicine for precision management of insulin resistance in type 2 diabetes mellitus through the gut microbiota-bile acids axis DOI Creative Commons

Yu Wang,

Jing Yu,

Binqin Chen

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Дек. 10, 2024

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance (IR) and insufficient secretion. Its characteristic pathophysiological processes involve the interaction of multiple mechanisms. In recent years, globally, prevalence T2DM has shown sharp rise due to profound changes in socio-economic structure, persistent influence environmental factors, complex role genetic background. It worth noting that most patients show significant IR, which further exacerbates difficulty progression prevention. process extensively exploring pathogenesis T2DM, dynamic equilibrium gut microbes its diverse activities have increasingly emphasized central T2DM. Bile acids (BAs) metabolism, as crucial link between development not only precisely regulates lipid absorption metabolism but also profoundly influences glucose homeostasis energy balance through intricate signaling pathways, thus playing pivotal IR This review aims delve into specific mechanism BAs contribute especially emphasizing how mediate transformation based on current traditional Chinese medicine research. Ultimately, it seeks offer new insights prevention treatment Diet, genetics, environment intricately sculpt microbiota influencing T2DM-IR. The research illuminated impact single herbal medicine, TCM formulae, external therapeutic methods such electroacupuncture pool perturbations structure. affects well sensitivity. Additionally, pathways including BA-FXR-SHP, BA-FXR-FGFR15/19, BA-FXR-NLRP3, BA-TGR5-GLP-1, BAs-TGR5/FXR been identified significantly alter blood levels improve IR. These findings novel approaches for enhancing managing disorders among with

Язык: Английский

A comparative neuro-study of solo or accompanied low and high boric acid doses with date molasses in adult male albino rats DOI
Mohamed M. Rezk

Environmental Analysis Health and Toxicology, Год журнала: 2024, Номер 39(4), С. e2024026 - e2024026

Опубликована: Ноя. 8, 2024

Boric acid (BA) is a weak and the simplest compound resulting from dissolution of boron in water. There great competition to determine whether an essential or nonessential nutrient. Date molasses potent type sweetener with valuable components, such as flavonoids phenolics, has significant health benefits. This study investigated neuro-essentiality neurotoxicity boric adult male albino rat cortex cerebellum brain areas impact date treatment. Animals were grouped into following groups: control, low high doses, 10 500 mg/kg, respectively, without 250 mg/kg molasses. The results revealed ability BAs cross blood-brain barrier accumulate cortex, revealing decrease BA accumulation at different time intervals. Additionally, varied between nonsignificant increase calcium ion content, monoamines (norepinephrine, dopamine, serotonin), glucose, adenosine triphosphate, malondialdehyde glutathione, depending on dose. Moreover, mitigated any unwanted results. In conclusion, acid, which within permissible limit, could be have neuroprotective effect, whereas sublethal level, it neurotoxic effect. can effects antagonize through its antioxidant scavenging effects.

Язык: Английский

Процитировано

0
Bile acids as a key target: traditional Chinese medicine for precision management of insulin resistance in type 2 diabetes mellitus through the gut microbiota-bile acids axis DOI Creative Commons

Yu Wang,

Jing Yu,

Binqin Chen

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Дек. 10, 2024

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease caused by insulin resistance (IR) and insufficient secretion. Its characteristic pathophysiological processes involve the interaction of multiple mechanisms. In recent years, globally, prevalence T2DM has shown sharp rise due to profound changes in socio-economic structure, persistent influence environmental factors, complex role genetic background. It worth noting that most patients show significant IR, which further exacerbates difficulty progression prevention. process extensively exploring pathogenesis T2DM, dynamic equilibrium gut microbes its diverse activities have increasingly emphasized central T2DM. Bile acids (BAs) metabolism, as crucial link between development not only precisely regulates lipid absorption metabolism but also profoundly influences glucose homeostasis energy balance through intricate signaling pathways, thus playing pivotal IR This review aims delve into specific mechanism BAs contribute especially emphasizing how mediate transformation based on current traditional Chinese medicine research. Ultimately, it seeks offer new insights prevention treatment Diet, genetics, environment intricately sculpt microbiota influencing T2DM-IR. The research illuminated impact single herbal medicine, TCM formulae, external therapeutic methods such electroacupuncture pool perturbations structure. affects well sensitivity. Additionally, pathways including BA-FXR-SHP, BA-FXR-FGFR15/19, BA-FXR-NLRP3, BA-TGR5-GLP-1, BAs-TGR5/FXR been identified significantly alter blood levels improve IR. These findings novel approaches for enhancing managing disorders among with

Язык: Английский

Процитировано

0