Gut microbiota as a new target for hyperuricemia: A perspective from natural plant products
Ling Dong,
Fengying Dong,
Pingping Guo
и другие.
Phytomedicine,
Год журнала:
2025,
Номер
138, С. 156402 - 156402
Опубликована: Янв. 18, 2025
Язык: Английский
The potential influence and intervention measures of gut microbiota on sperm: it is time to focus on testis-gut microbiota axis
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 8, 2024
As
the
global
male
infertility
rate
continues
to
rise,
there
is
an
urgent
imperative
investigate
underlying
causes
of
sustained
deterioration
in
sperm
quality.
The
gut
microbiota
emerges
as
a
pivotal
factor
host
health
regulation,
with
mounting
evidence
highlighting
its
dual
influence
on
semen.
This
review
underscores
interplay
between
Testis-Gut
axis
and
consequential
effects
sperm.
Potential
mechanisms
driving
impact
encompass
immune
modulation,
inflammatory
responses
mediated
by
endotoxins,
oxidative
stress,
antioxidant
defenses,
microbiota-derived
metabolites,
epigenetic
modifications,
regulatory
sex
hormone
signaling.
Interventions
such
probiotics,
prebiotics,
synbiotics,
fecal
transplantation,
Traditional
natural
herbal
extracts
are
hypothesized
rectify
dysbiosis,
offering
avenues
modulate
enhance
Spermatogenesis
motility.
Future
investigations
should
delve
into
elucidating
foundational
principles
governing
interaction
within
Axis.
Understanding
modulating
Axis
may
yield
novel
therapeutic
strategies
fertility
combat
decline
Язык: Английский
Qiangjing Tablets modulate oxidative stress and endoplasmic reticulum stress through the PI3K/Akt/NRF-2 signaling axis and regulate gut microbiota in ornidazole-induced asthenozoospermia rats
Journal of Traditional and Complementary Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Ginsenoside Rg5 modulates the TLR4 and BCL-2 pathways by inhibiting NOX1, thereby alleviating inflammation, apoptosis and pyroptosis in hyperuricemia nephropathy
Yuxin Zhang,
Hui Wan,
Guan-Yue Shan
и другие.
Journal of Ginseng Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Ganoderma lucidum alleviates kidney aging by modulating gut microbiota
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 31, 2024
Ganoderma
lucidum,
also
known
as
"Linzhi,"
is
a
well-established
traditional
Chinese
medicine
renowned
for
its
multiple
health
benefits
and
influence
on
gut
microbiota.
In
this
study,
we
investigated
the
anti-aging
effect
of
G.
lucidum
sporoderm-broken
spore
powder
(Gl-SBSP)
through
gut-kidney
axis
using
naturally
aged
radiation-induced
premature
senescence
mouse
models.
Administration
Gl-SBSP
not
only
effectively
mitigated
aging-related
phenotypic
changes
but
significantly
alleviated
kidney
aging,
although
outcomes
were
mixed
in
irradiation
model.
Importantly,
modulated
bacterial
composition,
particularly
enriching
Lachnospiraceae
mice
with
favorable
long-lasting
outcomes.
Nicotinamide
riboside
(NR),
derived
from
bacteria,
was
identified
potential
metabolite
that
facilitated
rejuvenation
senescent
kidneys
improved
renal
function
both
vitro
vivo
experiments.
Further
investigation
revealed
NR
regulated
steroid
metabolic
process
kidney.
Our
findings
suggest
mediated
by
thereby
influencing
metabolism
axis.
This
study
provides
novel
insights
into
mechanisms
Ganoderma.
Язык: Английский
Gut microbiota participates and remodels host metabolism: From treating patients to treating their gut flora
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(45), С. 4839 - 4843
Опубликована: Ноя. 13, 2024
In
this
editorial,
we
comment
on
Liu
et
al’
s
article
published
in
the
recent
issue
of
World
Journal
Gastroenterology
.
Biochemically
and
pathologically,
al
proved
that
urate-lowering
activity
leech
total
protein
(LTP)
was
mainly
attributed
to
rectification
gut
microbiota.
Specifically,
noticed
change
Bacteroides
Akkermansia
after
LTP
administration.
Both
bacteria
have
been
reported
alleviate
metabolic
dysfunction-associated
steatohepatitis
other
chronic
diseases.
administrated
through
intragastric
manners.
Most
possibly,
would
be
digested
by
microbiota
further.
The
anti-hyperuricemia
effects
should,
most
possible
extent,
exerted
peptides
or
their
secondary
products.
Human
communicates
with
organs
metabolites
generated
microbes
co-metabolized
host.
Whether
effect
could
partially
ascribed
also
deserves
discussed.
Although
metabolomics
analysis
performed
for
serum
samples,
fecal
highly
advocated
which
facilitate
exact
mechanism
explanation.
This
study
implied
contains
many
unexplored
targets
different
therapeutic
potentials.
It
is
foreseeable
utilizing
these
can
avoid
impairment
side
directly
using
human
some
extent.
Язык: Английский