Xiangsha Liujunzi Tang Alleviates Indomethacin-Induced Gastric Mucosal Injury by Inhibiting Nlrp3 Inflammasome-Mediated Pyroptosis in Rats

Опубликована: Янв. 1, 2025

Background: Gastric mucosal injury is a critical factor in the development and progression of numerous gastric disorders, problem increasing concern. Xiangsha Liujunzi Tang (XSLJZT) traditional herbal formula recognized for its ability to improve gastrointestinal function.Purpose: This study aimed investigate potential gastroprotective effects XSLJZT underlying mechanisms against indomethacin (IND)-induced rats.Methods: Bioinformatics molecular docking were employed identify targets pathways associated with injury. was manufactured quality-controlled using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Hematoxylin-eosin (H&E) staining transmission electron microscopy used assess surface morphology ultrastructure. Periodic acid-Schiff (PAS) ELISA utilized measure glycoproteins release pro-inflammatory anti-inflammatory cytokines rats IND-induced Immunofluorescence detect expression levels GSDMD, NF-κB, IKKβ, NLRP3, ASC, caspase-1 proteins elucidate XSLJZT's effects.Results: revealed that key signaling molecules NLRP3 inflammasome-mediated pyroptosis pathway may play role have strong binding affinities active ingredients XSLJZT. Animal experiments demonstrated significantly reduced ulcer index improved microstructure mucosa. Additionally, administration increased protective (IL-4, IL-10, IL-12) while decreasing mediators (IL-18, IL-1β, TNF-α). Further experimental validation confirmed markedly inhibited protein caspase-1.Conclusions: Our findings demonstrate exhibits promising on rats. ameliorates by inhibiting activation pathway, reducing IL-18, TNF-α, promoting IL-4, IL-12. These results suggest be therapeutic option various digestive disorders caused

Язык: Английский

Bibliometric and visualisation analyses of gastric ulcer knowledge areas and emerging trends, 2004–2024

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 21, 2025

Gastric ulcers are a form of peptic that present as ruptures the mucosal lining stomach or proximal intestinal extending beyond muscularis mucosae, and Helicobacter pylori infection is one main causative factors gastric ulcers. However, growing incidence drug resistance emergence specialised has necessitated continued research on This study surveyed global ulcer over past two decades with aim identifying major findings emerging trends in field. Bibliometric analysis was performed using search terms 'Gastric ulcer', disease', 'Gastrohelcoma', 'Stomach ulcers'. Data were extracted from Web Science Core Database (WoSCC) visualised CiteSpace software. The Journal Gastroenterology had most cited papers. largest number papers United States. frequently keywords 'Helicobacter pylori', 'peptic 'gastric ulcer'. field rapidly expanding, existing focused preventing occurrence ulcers, exploring pathogenesis new methods treating

Язык: Английский

Acidic polysaccharide CP-2 from Dioscoreae Rhizoma ameliorated acute alcoholic liver injury through the gut-liver axis and AMPK/PPAR pathway

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143145 - 143145

Опубликована: Апрель 1, 2025

Язык: Английский