Probiotic Limosilactobacillus reuteri DSM 17938 Alleviates Acute Liver Injury by Activating the AMPK Signaling via Gut Microbiota–Derived Propionate
Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Язык: Английский
The Potential of Metabolomics to Find Proper Biomarkers for Addressing the Neuroprotective Efficacy of Drugs Aimed at Delaying Parkinson’s and Alzheimer’s Disease Progression
Cells,
Год журнала:
2024,
Номер
13(15), С. 1288 - 1288
Опубликована: Июль 31, 2024
The
first
objective
is
to
highlight
the
lack
of
tools
measure
whether
a
given
intervention
affords
neuroprotection
in
patients
with
Alzheimer’s
or
Parkinson’s
diseases.
A
second
aim
present
primary
outcome
measures
used
clinical
trials
cohorts
neurodegenerative
final
discuss
metabolomics
using
body
fluids
may
lead
discovery
biomarkers
neuroprotection.
Information
on
related
and
disease
registered
since
2018
was
collected.
We
analysed
type
selected
assess
efficacy,
not
terms
since,
as
stated
aims,
there
yet
any
marker
Proteomic
approaches
plasma
CSF
have
been
proposed.
PET
could
estimate
extent
lesions,
but
progression
does
necessarily
correlate
change
tracer
uptake.
propose
some
alternatives
based
considering
metabolome.
new
opportunity
opens
because
impressive
technological
advances
that
allow
detection,
among
others,
metabolites
mitochondrial
function
structure
serum
and/or
cerebrospinal
fluid;
differentially
concentrated
can
become
reliable
Язык: Английский
Lindera aggregata improves intestinal function and alleviates depressive behaviors through the BDNF/TrkB/CREB signaling pathway induced by CUMS in mice
Brain Research,
Год журнала:
2024,
Номер
1846, С. 149295 - 149295
Опубликована: Окт. 28, 2024
Язык: Английский
Macadamia (Macadamia integrifolia) Oil Prevents High-Fat Diet-Induced Lipid Accumulation and Oxidative Stress by Activating the AMPK/Nrf2 Pathway
Foods,
Год журнала:
2024,
Номер
13(22), С. 3672 - 3672
Опубликована: Ноя. 18, 2024
Hyperlipidemia,
characterized
by
an
abnormal
lipid
metabolism,
is
related
to
multiple
cardiovascular
diseases
that
pose
challenges
global
public
health.
Macadamia
oil
(MO),
rich
in
monounsaturated
fatty
acids
(around
80%),
regarded
as
a
functional
used
regulate
accumulation.
Nonetheless,
the
lipid-lowering
mechanism
of
MO
still
unknown.
Therefore,
effects
high-fat
diet
(HFD)-induced
hyperlipidemic
mice
were
evaluated
this
study.
The
results
revealed
could
effectively
reduce
body
weight
and
organ
index
improve
serum
levels
reducing
total
cholesterol,
triglycerides,
low-density
lipoprotein
cholesterol
elevating
high-density
levels.
Additionally,
supplementation
liver
function
caused
hyperlipemia,
decreased
enzyme
levels,
including
alanine
aminotransferase
aspartate
aminotransferase.
Meanwhile,
also
exhibited
inhibitory
effect
on
oxidative
stress
accumulation
HFD.
Moreover,
findings
from
qRT-PCR
Western
blotting
analyses
suggest
markedly
prevented
hyperlipidemia
inhibiting
expression
AMPK
pathway-related
genes,
SREBP-1c,
FAS,
ACC,
PPAR-γ,
well
upregulating
Nrf2,
HO-1,
γ-GCS.
These
indicate
attenuates
vivo
via
AMPK/Nrf2
pathway
activation,
suggesting
serve
dietary
or
medication
for
treating
hyperlipidemia.
Язык: Английский