Gut microbiota: A new key of understanding for Panax notoginseng against multiple disorders and biotransformation

Journal of Ethnopharmacology, Год журнала: 2025, Номер 341, С. 119306 - 119306

Опубликована: Янв. 5, 2025

Язык: Английский

Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 14, 2025

Objective Chronic kidney disease (CKD) is a major global health problem. In clinical practice, the Chinese patent herbal medicine Jianpi-Yishen (JPYS) formula commonly used to treat CKD. However, molecular mechanisms by which JPYS targets and modulates host immune response remain unclear. Methods This study utilized network pharmacology, RNA sequencing (RNA-seq), metabolic analyses using in vivo vitro models investigate impact of on inflammation system. Specifically, focused macrophage polarization changes that may slow down progression Results A total 14,946 CKD-related were identified from GeneCards Online Mendelian Inheritance Man (OMIM) databases through pharmacology analyses. 227 potential predicted TCMSP database. Additionally, diagram demonstrated 11 associated with activity. studies indicated could reduce blood urea nitrogen serum creatinine adenine-induced CKD rats. Furthermore, inhibited inflammatory damage abnormal infiltration this model. RNA-seq, proteomic regulation amino acid metabolism betaine, specifically referring glycine, serine, threonine metabolism, as key target slowing addition, suggested enhance tryptophan M1 betaine M2 polarization. Conclusions The has been shown have beneficial CKD; mechanism mitigation interaction between Of specific importance context are roles

Язык: Английский

TEPP-46 inhibits glycolysis to promote M2 polarization of microglia after ischemic stroke

International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114148 - 114148

Опубликована: Фев. 3, 2025

Язык: Английский