The protective effect of crocin against paclitaxel-induced neurotoxicity
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
Paclitaxel-based
chemotherapy
is
an
important
treatment
option.
However,
paclitaxel
known
to
have
neurotoxic
side
effects.
This
study
investigated
the
neuroprotective
effect
of
crocin
against
paclitaxel-induced
neurotoxicity
in
human
SH-SY5Y
neuroblastoma
cell
lines.
A
series
tests
were
performed
assess
aspects
such
as
viability,
oxidative
stress,
genotoxicity,
and
apoptosis.
The
results
showed
that
decreased
viability
increased
LDH
levels,
while
combination
significantly
levels
compared
control.
In
addition,
this
caused
increase
total
antioxidant
capacity
a
decrease
oxidation
status.
Increased
micronuclei
sister
chromatid
formations
alleviated
by
adding
crocin.
Furthermore,
plus
most
impressively
activated
caspase-3/7
gene
expression.
suggested
had
promising
reducing
stress
genotoxicity
upregulating
pro-apoptotic
pathway.
Язык: Английский
Myristica fragrans water extract modulates multiple biological processes to pre-protect anhydrous ethanol-induced gastric ulcers via Akt/JNK/Nrf2 pathway activation
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
340, С. 119258 - 119258
Опубликована: Дек. 19, 2024
Язык: Английский
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
340, С. 119273 - 119273
Опубликована: Дек. 20, 2024
Язык: Английский