OVA-Induced Food Allergy Leads to Neurobehavioral Changes in Mice and the Potential Role of Gut Microbiota and Metabolites Dysbiosis DOI Open Access
Song Hu, Chunyan Zhou, Yue Zhang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4760 - 4760

Опубликована: Май 16, 2025

The neurobehavioral changes in food allergy mice have not been comprehensively studied, and the mechanism underlying them remains unclear. Our study aims to fully investigate OVA (ovalbumin)-sensitized explore potential via gut microbiota-brain axis. We established mouse (C57BL/6J male) model with OVA, evaluating anaphylactic symptoms levels of Th2 signature cytokine allergy-related antibodies serum. Using behavioral tests, we measured anxiety, depression, social behavior, repetitive attention, spatial memory control mice. In addition, analyzed prefrontal cortex for measuring inflammation-related indicators gathered serum untargeted metabolomics analysis feces 16S rDNA sequencing. exhibited significantly elevated IgE levels. addition anxiety-like, depression-like, behaviors, also displayed less interest damaged attention. TNF-α, IL-1β, IL-6 activation microglia were increased, which might explain neuronal damage. multi-omics technology, amino acid metabolism disruption, particularly carboxylic acids derivatives, was observed mice, remarkably correlated altered abundance microbiota related allergy. Behaviors OVA-induced extensively impaired. disruption associated dysbiosis play a pivotal role impairing neural immune homeostasis damage, could be responsible abnormalities.

Язык: Английский

Effects of Lutjanus erythropterus Protein on Depression-like Behavior and Gut Microbiota in Stressed Juvenile Mice DOI Creative Commons

Jinjin Luo,

Chen Wang,

Weichang Ye

и другие.

Foods, Год журнала: 2025, Номер 14(2), С. 330 - 330

Опубликована: Янв. 20, 2025

Lutjanus erythropterus protein (Lep) exhibits anti-inflammatory effects, but its antidepressant activity is unknown. This study used a 44-day chronic unpredictable mild stress (CUMS) model to determine whether Lep has beneficial effect through the gut–brain axis in 3-week-old male C57BL/6 mice. Gavaging with solution alleviated depression-like behavior and anxiety symptoms CUMS growing Administration of decreased serum IL-1β, IL-2, IL-6, TNF-α levels restored colonic mucosal damage. In addition, improved disturbance 5-hydroxytryptamine (5-HT) secretion axis. Pearson analysis revealed that gut short-chain fatty acid (SCFAs) concentration significantly (p < 0.05) correlated damage scores index. was able prevent SCFA enrichment. upregulated Muribaculaceae downregulated SCFA-producing bacteria by replenishing deficient amino (AA) (tryptophan, alanine, aspartate, glutamate) 0.01) gene abundance AA metabolism pathway bacteria, thereby preventing enrichment alleviating associated behavior. These findings indicate could attenuate depression juvenile mice via microbiota-SCFA–brain

Язык: Английский

Процитировано

0
A comprehensive pharmacology study reveals the molecular mechanisms underlying the antidepressant effects of Gastrodiae Rhizoma DOI
Pei Liu,

Zhihuang Zhao,

Haili Zhang

и другие.

Phytomedicine, Год журнала: 2025, Номер 142, С. 156761 - 156761

Опубликована: Апрель 19, 2025

Язык: Английский

Процитировано

0
The Pharmacological Effects of Gastrodin and the Progress in the Treatment of Neurological Disorders DOI
Han Guo, Dongmei Cheng,

Cong Zhang

и другие.

The American Journal of Chinese Medicine, Год журнала: 2025, Номер 53(03), С. 803 - 831

Опубликована: Янв. 1, 2025

Gastrodia elata Blume, a traditional medicinal herb primarily used in Asian countries such as China, has long been valued for treating headaches, dizziness, spasms, epilepsy, strokes, forgetfulness, and other ailments. Gastrodin, glycoside analog major bioactive component of garnered significant scientific attention owing to its extensive pharmacological effects. It is commonly obtained through plant extraction, chemical synthesis, biosynthesis. Gastrodin exhibits remarkable modulatory effects on the central nervous system (CNS), with promising applications neurodegenerative diseases Parkinson’s disease (PD) Alzheimer’s (AD), affective cognitive disorders. Furthermore, pharmacokinetics (PK) gastrodin extensively reviewed. As small molecule drug, this study focused efficiency molecular mechanisms CNS disorders, aiming elucidate interactions targets. This provides valuable insights development addresses drawbacks unclear Chinese medicine.

Язык: Английский

Процитировано

0
OVA-Induced Food Allergy Leads to Neurobehavioral Changes in Mice and the Potential Role of Gut Microbiota and Metabolites Dysbiosis DOI Open Access
Song Hu, Chunyan Zhou, Yue Zhang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4760 - 4760

Опубликована: Май 16, 2025

The neurobehavioral changes in food allergy mice have not been comprehensively studied, and the mechanism underlying them remains unclear. Our study aims to fully investigate OVA (ovalbumin)-sensitized explore potential via gut microbiota-brain axis. We established mouse (C57BL/6J male) model with OVA, evaluating anaphylactic symptoms levels of Th2 signature cytokine allergy-related antibodies serum. Using behavioral tests, we measured anxiety, depression, social behavior, repetitive attention, spatial memory control mice. In addition, analyzed prefrontal cortex for measuring inflammation-related indicators gathered serum untargeted metabolomics analysis feces 16S rDNA sequencing. exhibited significantly elevated IgE levels. addition anxiety-like, depression-like, behaviors, also displayed less interest damaged attention. TNF-α, IL-1β, IL-6 activation microglia were increased, which might explain neuronal damage. multi-omics technology, amino acid metabolism disruption, particularly carboxylic acids derivatives, was observed mice, remarkably correlated altered abundance microbiota related allergy. Behaviors OVA-induced extensively impaired. disruption associated dysbiosis play a pivotal role impairing neural immune homeostasis damage, could be responsible abnormalities.

Язык: Английский

Процитировано

0