Journal of Environmental Exposure Assessment,
Год журнала:
2025,
Номер
4(2)
Опубликована: Апрель 11, 2025
Chemical
composition
plays
a
crucial
role
in
the
adverse
health
effects
of
fine
particulate
matter
(PM2.5),
yet
traditional
methods
fail
to
comprehensively
identify
toxic
components.
In
this
study,
we
developed
non-targeted
approach
using
gas
chromatography
and
high-resolution
mass
spectrometry,
obtained
database
2,138
organic
components
from
PM2.5
samples
collected
urban
Beijing
between
2016
2018.
Meanwhile,
exposed
extracts
human
lung
epithelial
cell
line
measured
intracellular
reactive
oxygen
species
(ROS)
extracellular
cytokines
as
indicators
cellular
response.
A
combination
single
pollutant
model,
partial
least
squares
regression,
Bayesian
kernel
machine
regression
was
applied
filtered
165
robust
database.
Beyond
110
classic
polycyclic
aromatic
compounds
(PACs),
also
identified
14
anhydrides
21
nitrated
contributors
toxicity.
Molecular
features
such
unsaturation
volatility
were
found
be
most
significant
factors
influencing
effects.
Source
apportionment
analysis
demonstrated
distinct
seasonal
patterns
toxicological
impacts.
During
heating
season,
biomass
burning
emerged
predominant
pollution
source,
with
its
two-fold
intensity
elevation
correlating
2.0%
increase
tumor
necrosis
factor
(TNF)-α,
accompanied
by
6.0%
7.6%
decreases
vascular
endothelial
growth
(VEGF)
interleukin
(IL)-8,
respectively.
contrast,
non-heating
season
observations
revealed
vehicular
emission
principal
contributor,
inducing
pronounced
11.0%
ROS
levels.
This
study
introduces
an
effect-oriented
for
screening
ambient
PM2.5,
offering
valuable
insights
support
formulation
public
protection
strategies.
Atmosphere,
Год журнала:
2025,
Номер
16(3), С. 292 - 292
Опубликована: Фев. 28, 2025
PM2.5
in
air
pollution
poses
a
significant
threat
to
public
health
and
the
ecological
environment.
There
is
an
urgent
need
develop
accurate
prediction
models
support
decision-making
reduce
risks.
This
review
comprehensively
explores
progress
of
concentration
prediction,
covering
bibliometric
trends,
time
series
data
characteristics,
deep
learning
applications,
future
development
directions.
article
obtained
on
2327
journal
articles
published
from
2014
2024
WOS
database.
Bibliometric
analysis
shows
that
research
output
growing
rapidly,
with
China
United
States
playing
leading
role,
recent
increasingly
focusing
data-driven
methods
such
as
learning.
Key
sources
include
ground
monitoring,
meteorological
observations,
remote
sensing,
socioeconomic
activity
data.
Deep
(including
CNN,
RNN,
LSTM,
Transformer)
perform
well
capturing
complex
temporal
dependencies.
With
its
self-attention
mechanism
parallel
processing
capabilities,
Transformer
particularly
outstanding
addressing
challenges
long
sequence
modeling.
Despite
these
advances,
integration,
model
interpretability,
computational
cost
remain.
Emerging
technologies
meta-learning,
graph
neural
networks,
multi-scale
modeling
offer
promising
solutions
while
integrating
into
real-world
applications
smart
city
systems
can
enhance
practical
impact.
provides
informative
guide
for
researchers
novices,
providing
understanding
cutting-edge
methods,
systematic
paths.
It
aims
promote
robust
efficient
contribute
global
management
protection
efforts.
Environment & Health,
Год журнала:
2023,
Номер
1(3), С. 150 - 167
Опубликована: Авг. 8, 2023
The
oxygen
(OPAHs),
nitro
(NPAHs),
hydroxyl
(OH-PAHs),
and
alkylated
(APAHs)
derivatives
of
polycyclic
aromatic
hydrocarbon
(PAHs)
are
ubiquitous
pollutants
in
the
environment.
concentrations
NPAHs,
OPAHs,
OH-PAHs,
APAHs
lower
than
that
PAHs
environment,
but
carcinogenic
abilities
usually
10
to
1,000-fold
higher
parent
PAHs.
There
three
main
pathways
for
exposure
compounds
humans,
including
inhalation,
direct
contact,
ingestion.
After
by
they
mainly
distributed
lungs,
affecting
lung
function
causing
inflammation,
asthma,
etc.
Due
digestive
system's
strong
capacity
metabolism,
intake
is
primarily
system
metabolized
there.
And
it
may
lead
dysplasia
these
organs
even
cancer.
skin
primary
site
contact
with
PAH
derivatives.
can
enter
bloodstream
through
all
pathways,
thereby
accumulating
various
organs.
This
study
aimed
summarize
influence
on
tissue
distribution
health
impact
provide
references
future
research
evaluation
public
health.
European Respiratory Review,
Год журнала:
2024,
Номер
33(173), С. 230259 - 230259
Опубликована: Июль 1, 2024
Particulate
matter
with
a
diameter
≤2.5
μm
(PM
2.5
)
poses
substantial
global
challenge,
growing
recognition
of
pathogens
contributing
to
diseases
associated
exposure
PM
.
Recent
studies
have
focused
on
,
which
impairs
the
immune
cells
in
response
microbial
infections
and
potentially
contributes
development
severe
respiratory
tract.
Accordingly,
changes
function
microecology
mediated
by
are
important
factors
that
enhance
risk
pathogenesis.
These
garnered
significant
interest.
In
this
review,
we
summarise
recent
potential
mechanisms
involved
-mediated
system
disruption
exacerbation
pathogenesis
We
also
discuss
crucial
areas
for
future
research
address
gaps
our
understanding
develop
effective
strategies
combat
adverse
health
effects
Rapid Prototyping Journal,
Год журнала:
2024,
Номер
30(5), С. 1046 - 1054
Опубликована: Май 6, 2024
Purpose
Three-dimensional
(3D)printed
skulls
for
neurosurgical
training
are
increasingly
being
used
due
to
the
widespread
access
3D
printing
technology,
their
low
cost
and
accuracy,
as
well
limitations
ethical
concerns
associated
with
using
human
cadavers.
However,
little
is
known
about
risks
of
airborne
particles
or
volatile
organic
compounds
(VOCs)
released
while
drilling
into
3D-printed
plastic
models.
The
aim
this
study
assess
level
exposure
contaminants
burr
hole
drilling.
Design/methodology/approach
skull
samples
were
produced
three
different
materials
(polyethylene
terephthalate
glycol
[PETG],
white
resin
Bone
STN
)
across
print
processes
(fused
filament
fabrication,
stereolithography
[SLA]
material
jetting).
A
neurosurgeon
performed
extended
10
min
on
each
sample.
Spot
measurements
particulate
matter
(PM2.5
PM10)
recorded,
air
analysed
approximately
90
VOCs.
Findings
PETG
was
found
be
below
threshold
value
respirable
particles.
above
at
PM10,
which
could
harmful
long
periods
without
personal
protective
equipment
(PPE).
VOC
all
safety
thresholds,
therefore
not
harmful.
Originality/value
To
best
authors’
knowledge,
first
evaluate
surgical
It
recommends
a
safe
requiring
minimal
respiratory
control
measures,
whereas
resin-based
will
require
controls
deal
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
283, С. 116793 - 116793
Опубликована: Авг. 1, 2024
Biomass-related
airborne
fine
particulate
matter
(PM2.5)
is
an
important
risk
factor
for
chronic
obstructive
pulmonary
disease
(COPD).
Macrophage
polarization
has
been
reported
to
be
involved
in
PM2.5-induced
COPD,
but
the
dynamic
characteristics
and
underlying
mechanism
of
this
process
remain
unclear.
Our
study
established
a
COPD
mouse
model
revealed
that
M2
macrophages
predominantly
presented
after
4
6
months
PM2.5
exposure,
during
which
notable
increase
MMP12
was
observed.
Single
cell
analysis
lung
tissues
from
patients
mice
further
were
dominant
macrophage
subpopulation
with
being
as
hub
gene.
In
vitro
experiments
demonstrated
induced
increased
expression.
Moreover,
we
found
IL-4
expression,
STAT6
phosphorylation
nuclear
translocation.
Nuclear
pSTAT6
then
bound
promoter
region.
Furthermore,
inhibition
effectively
abrogated
MMP12.
Using
coculture
system,
observed
significantly
reduced
level
E-cadherin
alveolar
epithelial
cells
cocultured
PM2.5-exposed
macrophages,
while
decrease
reversed
by
addition
inhibitor
co-culture
system.
Taken
together,
these
findings
indicated
upregulation
via
IL-4/STAT6
pathway,
resulted
barrier
dysfunction
excessive
extracellular
matrix
(ECM)
degradation,
ultimately
led
progression.
These
may
help
elucidate
role
suggest
promising
directions
potential
therapeutic
strategies.
